Gene info: ID 1235

Gene: CCR6

GENE ID: 1235

Description: C-C motif chemokine receptor 6

Gene type: protein-coding

Location: 6q27

dbXrefs: Ensembl:ENSG00000112486 MIM:601835 Vega:OTTHUMG00000016015 UniprotKB:P51684

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 10

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.802e-1 (AD) 3.924e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ORC6	0.829
VPS33B	0.814
PRC1	0.811
LMO7	0.799
RYR2	0.796
POLR3A	0.791
COG1	0.787
SORCS1	0.787
TMEM63C	0.786
VPS33A	0.784

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YES1	-0.477
MTRNR2L9	-0.463
MTRNR2L6	-0.46
MSX1	-0.444
MTRNR2L10	-0.442
RAI14	-0.437
TSPAN12	-0.436
TMEM51	-0.429
MAPKAPK3	-0.428
KCNJ16	-0.426

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C032668	1-nitropyrene	1-nitropyrene results in decreased expression of CCR6 mRNA	19428942
C029728	4-phenylenediamine	4-phenylenediamine results in decreased expression of CCR6 protein	15924226
D000082	Acetaminophen	Acetaminophen results in decreased expression of CCR6 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CCR6 gene	27153756
D015081	2-Naphthylamine	2-Naphthylamine results in decreased expression of CCR6 mRNA	18247414
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CCR6 mRNA	24449571
D001151	Arsenic	Arsenic affects the expression of CCR6 protein	24675094
D001280	Atrazine	Atrazine results in increased expression of CCR6 mRNA	22982499
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of CCR6 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CCR6 mRNA	18247414
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CCR6 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CCR6 mRNA	21569818
C006780	bisphenol A	bisphenol A results in decreased expression of CCR6 mRNA	25181051
C006794	brevianamide A	brevianamide A results in increased expression of CCR6 mRNA	19818335
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CCR6 mRNA	24982889
C100187	chloropicrin	chloropicrin results in increased expression of CCR6 mRNA	26352163
C000488	cladosporin	cladosporin results in increased expression of CCR6 mRNA	19818335
C038459	curdlan	curdlan affects the expression of CCR6 mRNA	19904525
D016572	Cyclosporine	Cyclosporine results in decreased expression of CCR6 mRNA	25562108
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CCR6 mRNA	23326479
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of CCR6 mRNA	26924002
D004041	Dietary Fats	Dietary Fats results in increased expression of CCR6 mRNA	25016146
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CCR6 mRNA"	27840820
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CCR6 mRNA	26924002
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in decreased expression of CCR6 protein	15924226
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CCR6 mRNA	15885639
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR6 mRNA	17942748
C020748	ferrous sulfate	ferrous sulfate results in decreased expression of CCR6 mRNA	19428942
C039281	furan	furan results in increased expression of CCR6 mRNA	27387713
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCR6 mRNA	25613284
C051890	irinotecan	irinotecan metabolite results in decreased expression of CCR6 mRNA	15956246
C051890	irinotecan	irinotecan results in decreased expression of CCR6 mRNA	15956246
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CCR6 mRNA	26387944\|2675264
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of CCR6 mRNA	27432991
C045463	leflunomide	leflunomide results in increased expression of CCR6 mRNA	28988120
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in decreased expression of CCR6 mRNA"	23090859
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CCR6 protein	15924226
D015122	Mercaptopurine	Mercaptopurine results in decreased expression of CCR6 mRNA	23358152
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of CCR6 mRNA	26924002
D009173	Mycophenolic Acid	Mycophenolic Acid results in increased expression of CCR6 mRNA	19818335
D009183	Mycotoxins	Mycotoxins results in increased expression of CCR6 mRNA	19818335
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CCR6 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CCR6 mRNA"	25554681
C015380	neoechinulin	neoechinulin results in increased expression of CCR6 mRNA	19818335
C490266	neoechinulin A	neoechinulin A results in increased expression of CCR6 mRNA	19818335
D009532	Nickel	Nickel results in decreased expression of CCR6 mRNA	14575637
D009532	Nickel	Nickel results in increased expression of CCR6 mRNA	25583101
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of CCR6 mRNA]	14575637
C029938	nickel sulfate	nickel sulfate results in decreased expression of CCR6 protein	15924226
D009538	Nicotine	Nicotine results in decreased expression of CCR6 mRNA	18247414
D010261	Paraoxon	Paraoxon results in increased expression of CCR6 mRNA	24413757
D052638	Particulate Matter	CCR6 protein affects the susceptibility to Particulate Matter	21906792
D015232	Dinoprostone	[Dinoprostone co-treated with IL1B co-treated with IL23A] affects the expression of CCR6	19273625
D011794	Quercetin	Quercetin results in decreased expression of CCR6 mRNA	21632981
C059514	resveratrol	resveratrol results in decreased expression of CCR6 mRNA	21340626
C059514	resveratrol	resveratrol results in decreased expression of CCR6 protein	21340626
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of CCR6 mRNA	21127053
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of CCR6 mRNA	19428942
C017947	sodium arsenite	sodium arsenite affects the methylation of CCR6 gene	28589171
D053260	Soot	Soot results in decreased expression of CCR6 mRNA	19428942
D053260	Soot	Soot results in decreased expression of CCR6 mRNA	26551751
D013241	Sterigmatocystin	Sterigmatocystin results in increased expression of CCR6 mRNA	19818335
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCR6 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCR6 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCR6 mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in decreased expression of CCR6 mRNA	27760801
C009495	titanium dioxide	titanium dioxide results in increased expression of CCR6 mRNA	23557971
C402696	TMC 120A	TMC 120A results in increased expression of CCR6 mRNA	19818335
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of CCR6 protein"	27103660
D014212	Tretinoin	Tretinoin results in increased expression of CCR6 protein	15454112
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of CCR6 mRNA]	14575637
D014520	Urethane	Urethane results in decreased expression of CCR6 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased methylation of CCR6 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CCR6 gene	25487561
D001335	Vehicle Emissions	CCR6 protein affects the susceptibility to Vehicle Emissions	21906792
C016837	zinc chloride	zinc chloride results in decreased expression of CCR6 mRNA	19428942

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004950	chemokine receptor activity	-	TAS	11001880
GO:0005515	protein binding	-	IPI	20068036 25122636
GO:0016493	C-C chemokine receptor activity	-	IBA	21873635
GO:0016493	C-C chemokine receptor activity	-	IDA	20068036
GO:0016493	C-C chemokine receptor activity	-	IMP	12081481
GO:0019956	chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IBA	21873635
GO:0019957	C-C chemokine binding	-	IDA	20068036
GO:0019957	C-C chemokine binding	-	IMP	12081481
GO:0038023	signaling receptor activity	-	TAS	9186513

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002407	dendritic cell chemotaxis	-	TAS	16621978
GO:0002523	leukocyte migration involved in inflammatory response	-	ISS	-
GO:0006935	chemotaxis	-	IBA	21873635
GO:0006935	chemotaxis	-	IDA	20068036
GO:0006935	chemotaxis	-	IMP	12081481
GO:0006955	immune response	-	IBA	21873635
GO:0006955	immune response	-	TAS	9223454
GO:0006959	humoral immune response	-	TAS	11001880
GO:0006968	cellular defense response	-	TAS	10521347
GO:0007165	signal transduction	-	TAS	9186513
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0007204	positive regulation of cytosolic calcium ion concentration	-	IEA	-
GO:0010634	positive regulation of epithelial cell migration	-	IEA	-
GO:0019722	calcium-mediated signaling	-	IBA	21873635
GO:0019722	calcium-mediated signaling	-	IMP	12081481
GO:0048290	isotype switching to IgA isotypes	-	ISS	-
GO:0060326	cell chemotaxis	-	IBA	21873635
GO:0060326	cell chemotaxis	-	IDA	23765988
GO:0060474	positive regulation of flagellated sperm motility involved in capacitation	-	IDA	23765988
GO:0070098	chemokine-mediated signaling pathway	-	IEA	-
GO:0072676	lymphocyte migration	-	ISS	-
GO:0072678	T cell migration	-	ISS	-
GO:0072679	thymocyte migration	-	IBA	21873635
GO:0072679	thymocyte migration	-	ISS	-
GO:1904155	DN2 thymocyte differentiation	-	ISS	-
GO:1904156	DN3 thymocyte differentiation	-	ISS	-
GO:2000404	regulation of T cell migration	-	ISS	-
GO:2000510	positive regulation of dendritic cell chemotaxis	-	IBA	21873635
GO:2000510	positive regulation of dendritic cell chemotaxis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005622	intracellular	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	9186513
GO:0009897	external side of plasma membrane	-	IBA	21873635
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0009986	cell surface	-	IDA	12081481
GO:0036126	sperm flagellum	-	IDA	23765988
GO:0097225	sperm midpiece	-	IDA	23765988
GO:0097228	sperm principal piece	-	IDA	23765988
GO:0097524	sperm plasma membrane	-	IDA	23765988

KEGG ID	KEGG Term
hsa04060	Cytokine-cytokine receptor interaction
hsa04062	Chemokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1461957	Beta defensins	TAS
R-HSA-1461973	Defensins	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-380108	Chemokine receptors bind chemokines	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6803157	Antimicrobial peptides	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29515587	T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder. (2018)	Patas K	Front Immunol
26667180	Dysregulation of CD4(+) T Cell Subsets in Intracranial Aneurysm. (2016 Feb)	Zhang HF	DNA Cell Biol
26293897	IL-22 promotes the proliferation of cancer cells in smoking colorectal cancer patients. (2016 Jan)	Song B	Tumour Biol
29309749	Patients with idiopathic endplate inflammation displayed aberrant Th17 responses resulting in proinflammatory monocyte activation. (2018 Feb 1)	Wang J	Exp Cell Res
23895590	Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells. (2013 Dec)	Parlet CP	Alcohol Clin Exp Res
23288628	Genetics of rheumatoid arthritis - a comprehensive review. (2013 Oct)	Kurko J	Clin Rev Allergy Immunol
21537330	Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT. (2011 Jul)	Verschuere S	Lab Invest
23577190	PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)	Suzuki T	PLoS One
28179539	Smoking reduces circulating CD26(hi)CD161(hi) MAIT cells in healthy individuals and patients with multiple sclerosis. (2017 May)	Ammitzboll C	J Leukoc Biol
25879557	Evaluation of blood redox-balance, nitric oxide content and CCR6 rs3093024 in the genetic susceptibility during psoriasis. (2015 Mar)	Matoshvili M	Georgian Med News