Gene: HYKK

123688
AGPHD1
hydroxylysine kinase
protein-coding
15q25.1
Ensembl:ENSG00000188266 MIM:614681 Vega:OTTHUMG00000177204 UniprotKB:A2RU49
NC_000015.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.482e-1 (AD)  1.000e-12 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs34684276chr15:78520813 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTHFD10.745
MPP60.718
WDR310.718
PBX10.713
ACADSB0.705
TTC80.702
NDUFS10.7
TMEM1920.698
DOCK40.698
DLD0.697

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG8-0.391
SFN-0.38
TGFB3-0.377
SGMS2-0.376
OR4F5-0.36
LBX2-0.353
MAFF-0.347
BEST3-0.343
C7orf61-0.341
TMEM139-0.341

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HYKK mRNA"25380136
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to HYKK protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to HYKK protein]26598702
D000082AcetaminophenAcetaminophen results in decreased expression of HYKK mRNA29067470
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HYKK mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to HYKK protein]26598702
C547126AZM551248AZM551248 results in decreased expression of HYKK mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of HYKK mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of HYKK gene25435355
C006780bisphenol Abisphenol A results in decreased expression of HYKK mRNA25181051
C584509C646 compoundC646 compound results in increased expression of HYKK mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HYKK mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HYKK mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of HYKK mRNA23125180
D016572CyclosporineCyclosporine results in decreased expression of HYKK mRNA19770486
D002945CisplatinCisplatin results in increased expression of HYKK mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of HYKK mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of HYKK mRNA25016146
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of HYKK mRNA25380136
C069837fullerene C60fullerene C60 results in decreased expression of HYKK mRNA19167457
D005897GlafenineGlafenine results in decreased expression of HYKK mRNA24136188
D017313FenretinideFenretinide results in decreased expression of HYKK mRNA28973697
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in increased expression of HYKK mRNA26667767
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HYKK mRNA"20188158
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of HYKK mRNA25380136
D009532NickelNickel results in decreased expression of HYKK mRNA24768652|2558310
D010634PhenobarbitalPhenobarbital results in decreased expression of HYKK mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of HYKK mRNA23811191
C045950propiconazolepropiconazole results in decreased expression of HYKK mRNA21278054
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in increased expression of HYKK mRNA26667767
C016104sodium bichromatesodium bichromate results in decreased expression of HYKK mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HYKK mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HYKK mRNA19770486
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of HYKK mRNA28973375
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HYKK mRNA20133372
C057693troglitazonetroglitazone results in decreased expression of HYKK mRNA28973697
D014638VanadatesVanadates results in decreased expression of HYKK mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HYKK gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of HYKK mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IBA21873635  
GO:0019202amino acid kinase activity-IBA21873635  
GO:0047992hydroxylysine kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006520cellular amino acid metabolic process-IBA21873635  
GO:0006554lysine catabolic process-TAS-  
GO:0016310phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71064Lysine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29422661Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics. (2018 May)Nedeljkovic IEur J Hum Genet
26220977A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. (2015 Oct 15)Hancock DBHum Mol Genet