Gene: NTAN1

123803
PNAA|PNAD
N-terminal asparagine amidase
protein-coding
16p13.11
Ensembl:ENSG00000157045 MIM:615367 Vega:OTTHUMG00000129849 UniprotKB:Q96AB6
NC_000016.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.974e-1 (AD)  1.435e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07456681chr16:15146876NTAN11.100e-14Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDUFA120.893
SSU720.89
JTB0.887
OAZ10.885
NME1-NME20.885
NDUFB80.885
NDUFB100.882
SRSF90.876
NDUFS50.875
COX4I10.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.823
OR4F29-0.793
SLC26A5-0.205
KCNJ15-0.171
VNN3-0.17
MMP9-0.165
RAET1E-0.163
CXCR1-0.16
OR6C74-0.16
PRDM14-0.157

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of NTAN1 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of NTAN1 mRNA"19095052
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of NTAN1 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of NTAN1 mRNA]"19414516
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of NTAN1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of NTAN1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of NTAN1 mRNA17585979
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of NTAN1 mRNA]"19414516
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NTAN1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NTAN1 mRNA"19150397
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of NTAN1 mRNA26496021
C018475butyraldehydebutyraldehyde results in increased expression of NTAN1 mRNA26079696
D019327Copper SulfateCopper Sulfate results in increased expression of NTAN1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of NTAN1 mRNA25562108|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NTAN1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NTAN1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NTAN1 mRNA27392435|2759478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NTAN1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NTAN1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTAN1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of NTAN1 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NTAN1 mRNA22634610
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of NTAN1 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NTAN1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NTAN1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of NTAN1 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of NTAN1 mRNA23649840
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of NTAN1 mRNA19095052
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of NTAN1 protein19854247
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NTAN1 mRNA19710929
D011794QuercetinQuercetin results in increased expression of NTAN1 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of NTAN1 mRNA20436886
D013629TamoxifenTamoxifen affects the expression of NTAN1 mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of NTAN1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NTAN1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NTAN1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NTAN1 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of NTAN1 mRNA26217789
C057693troglitazonetroglitazone results in increased expression of NTAN1 protein21315101
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of NTAN1 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of NTAN1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of NTAN1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008418protein-N-terminal asparagine amidohydrolase activity-IDA21375249  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IDA21375249  
GO:0007613memory-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19786961Copy number variations of chromosome 16p13.1 region associated with schizophrenia. (2011 Jan)Ingason AMol Psychiatry