Gene: CMTM3

123920
BNAS2|CKLFSF3
CKLF like MARVEL transmembrane domain containing 3
protein-coding
16q22.1
Ensembl:ENSG00000140931 MIM:607886 Vega:OTTHUMG00000137503 UniprotKB:Q96MX0
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.673e-1 (AD)  7.686e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRAM10.865
GYPC0.863
SLC43A30.861
TIMP10.856
CXCL160.854
WWTR10.853
S100A110.853
CLIC10.849
GPSM30.847
PYGL0.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.633
KCNB2-0.623
CALHM1-0.621
HCN1-0.612
MARCH4-0.608
ABCC12-0.6
C11orf87-0.595
CHRNB2-0.594
ST6GALNAC5-0.591
NDST3-0.59

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CMTM3 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of CMTM3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CMTM3 mRNA27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CMTM3 mRNA22316170|2623829
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CMTM3 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CMTM3 mRNA20660070
D004958EstradiolEstradiol results in increased expression of CMTM3 mRNA19484750
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CMTM3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CMTM3 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of CMTM3 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CMTM3 mRNA17484886|2733941
D002737ChloropreneChloroprene results in decreased expression of CMTM3 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of CMTM3 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of CMTM3 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of CMTM3 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CMTM3 mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CMTM3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CMTM3 mRNA17361019|2126653
D002945CisplatinCisplatin results in decreased expression of CMTM3 mRNA22023808
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CMTM3 mRNA16636312
D002117CalcitriolCalcitriol results in decreased expression of CMTM3 mRNA26485663
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CMTM3 mRNA25380136
D004237DiuronDiuron results in decreased expression of CMTM3 mRNA25152437
C540355fenamidonefenamidone results in increased expression of CMTM3 mRNA27029645
C039281furanfuran results in decreased methylation of CMTM3 gene27387713
C039281furanfuran results in increased expression of CMTM3 mRNA27387713
D017313FenretinideFenretinide results in increased expression of CMTM3 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CMTM3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CMTM3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CMTM3 mRNA28628672
C410337K 7174K 7174 results in increased expression of CMTM3 mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CMTM3 mRNA27339419
D008694MethamphetamineMethamphetamine results in decreased methylation of CMTM3 promoter26307267
C523799MRK 003CMTM3 results in increased susceptibility to MRK 00319903844
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CMTM3 mRNA25380136
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CMTM3 mRNA25729387
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CMTM3 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CMTM3 mRNA18301758
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CMTM3 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CMTM3 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of CMTM3 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CMTM3 mRNA27029645
D012999SomanSoman results in increased expression of CMTM3 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CMTM3 mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CMTM3 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CMTM3 mRNA25729387
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CMTM3 mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of CMTM3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CMTM3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of CMTM3 gene29154799
D014640VancomycinVancomycin results in decreased expression of CMTM3 mRNA18930951
D024483Vitamin K 3Vitamin K 3 affects the expression of CMTM3 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0050861positive regulation of B cell receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0031965nuclear membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27521994Elevated methylation of CMTM3 promoter in the male laryngeal squamous cell carcinoma patients. (2016 Nov)Shen ZClin Biochem