Gene: LTB4R

1241
BLT1|BLTR|CMKRL1|GPR16|LTB4R1|LTBR1|P2RY7|P2Y7
leukotriene B4 receptor
protein-coding
14q12
Ensembl:ENSG00000213903 MIM:601531 Vega:OTTHUMG00000029346 UniprotKB:Q15722
NC_000014.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.675e-2 (AD)  2.504e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07042014chr14:24783620LTB4R4.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCHSD10.833
ALPK10.79
ZNF6000.78
EZH20.778
ZNF7000.777
MAP3K80.76
CACNA2D40.743
TLDC20.743
MAN2B10.741
PSTPIP20.739

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WNT7A-0.466
CPLX3-0.435
CRH-0.405
ARSF-0.4
VIP-0.384
HES5-0.374
KIT-0.374
C1orf53-0.361
ASPDH-0.36
WNT7B-0.36

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06248AmelubantSmall Molecule346735-24-8InvestigationalTarget
DB09285MorniflumateSmall Molecule65847-85-0ApprovedTarget
DB12961Leukotriene B4Small Molecule71160-24-2InvestigationalTarget
ID Drug Name Action PubMed
C0636091,2-dimethyl-4-nitrobenzene"1,2-dimethyl-4-nitrobenzene results in decreased expression of LTB4R mRNA"19784758
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LTB4R mRNA"19114083
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of LTB4R mRNA19038236
C0822067-(3-(2-(cyclopropylmethyl)-3-methoxy-4-((methylamino)carbonyl)phenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid"7-(3-(2-(cyclopropylmethyl)-3-methoxy-4-((methylamino)carbonyl)phenoxy)propoxy)-3,4-dihydro-8-propyl-2H-1-benzopyran-2-propanoic acid binds to and results in decreased activity of LTB4R protein"7812673
D000082AcetaminophenAcetaminophen results in decreased expression of LTB4R mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of LTB4R mRNA19784758
D000082AcetaminophenAcetaminophen results in decreased expression of LTB4R mRNA19784758
D000082AcetaminophenAcetaminophen results in increased expression of LTB4R mRNA19784758
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LTB4R mRNA16483693
D001374AzacitidineAzacitidine results in decreased expression of LTB4R mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of LTB4R mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of LTB4R mRNA19784758
D003300Copper[Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA24690739
C089698CP 105696CP 105696 binds to and results in decreased activity of LTB4R protein7714764|8666909
C089698CP 105696CP 105696 inhibits the reaction [PTGR1 protein binds to LTB4R protein]7714764
C089698CP 105696CP 105696 binds to and results in decreased activity of LTB4R protein19880577
D002117CalcitriolCalcitriol results in decreased expression of LTB4R mRNA26485663
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of LTB4R mRNA"27840820
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of LTB4R mRNA24690739
D005419FlavonoidsFlavonoids results in decreased expression of LTB4R mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of LTB4R mRNA23649840
D005557FormaldehydeLTB4R protein results in increased susceptibility to Formaldehyde19835937
D005557FormaldehydeMK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde]19835937
D007975Leukotriene B4Leukotriene B4 binds to and results in increased activity of LTB4R protein7473568
D007975Leukotriene B4LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D007975Leukotriene B4LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D007975Leukotriene B4LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D007975Leukotriene B4Leukotriene B4 binds to and results in increased activity of LTB4R protein7473568
D007975Leukotriene B4LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D007975Leukotriene B4LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D007975Leukotriene B4LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D007975Leukotriene B4[SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B48014878
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of LTB4R protein17337753
C063823LY 255283LY 255283 analog binds to and results in decreased activity of LTB4R protein7473568
C063823LY 255283LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
C063823LY 255283LY 255283 binds to and results in decreased activity of LTB4R protein7473568
C063823LY 255283LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
C063823LY 255283LY 255283 analog binds to and results in decreased activity of LTB4R protein7473568
C063823LY 255283LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
C063823LY 255283LY 255283 binds to and results in decreased activity of LTB4R protein7473568
C063823LY 255283LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
C094099LY 293111LY 293111 binds to and results in decreased activity of LTB4R protein7473568
C094099LY 293111LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
C094099LY 293111LY 293111 binds to and results in decreased activity of LTB4R protein7473568
C094099LY 293111LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]7473568
D008727MethotrexateMethotrexate results in decreased expression of LTB4R mRNA24449571
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of LTB4R mRNA28349193
C060893MK-886MK-886 binds to and results in decreased activity of LTB4R protein19835937
C060893MK-886MK-886 inhibits the reaction [LTB4R protein results in increased susceptibility to Formaldehyde]19835937
D009532NickelNickel results in increased expression of LTB4R mRNA25583101
D009578NitrobenzenesNitrobenzenes analog results in decreased expression of LTB4R mRNA19784758
C067523ONO-LB 457ONO-LB 457 binds to and results in decreased activity of LTB4R protein11886531
C104857PH 163PH 163 binds to and results in decreased activity of LTB4R protein12654629
D011794QuercetinQuercetin results in increased expression of LTB4R mRNA21632981
C059950SC 41930SC 41930 binds to and results in decreased activity of LTB4R protein7812673|8014878
C059950SC 41930[SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B48014878
C059950SC 41930SC 41930 binds to LTB4R protein7812673
D014284Triiodothyronine[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA14761676
C061133tamibarotenetamibarotene affects the expression of LTB4R mRNA15498508
D013749Tetrachlorodibenzodioxin[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA14761676
D013853ThioacetamideThioacetamide results in decreased expression of LTB4R mRNA19784758
D014212TretinoinTretinoin affects the expression of LTB4R mRNA15498508
D014212TretinoinTretinoin results in increased expression of LTB4R mRNA17218384
C062137U 75302U 75302 binds to and results in decreased activity of LTB4R protein16313356
C025643vinclozolinvinclozolin results in decreased expression of LTB4R mRNA23869203
C016837zinc chloridezinc chloride results in decreased expression of LTB4R mRNA19428942

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000166nucleotide binding-TAS8702478  
GO:0001631cysteinyl leukotriene receptor activity-IBA21873635  
GO:0001632leukotriene B4 receptor activity-IBA21873635  
GO:0001632leukotriene B4 receptor activity-IEA-  
GO:0004966galanin receptor activity-IBA21873635  
GO:0004974leukotriene receptor activity-TAS9177352  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS8702478  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-TAS9177352  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-TAS8702478  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0061737leukotriene signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9177352  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391906Leukotriene receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19038236Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)Prokopczyk BChem Biol Interact
22206291The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. (2011 Dec 29)Tulah ASBMC Med Genet