Gene: GPR139

124274
GPRg1|PGR3
G protein-coupled receptor 139
protein-coding
16p12.3
Ensembl:ENSG00000180269 Vega:OTTHUMG00000177690 UniprotKB:Q6DWJ6
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.817e-1 (AD)  2.800e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1886712chr16:20072371 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZBED20.806
ENTHD10.775
LHX80.756
SLC22A250.755
UPK1B0.752
GPR1010.745
DRD30.742
TNFRSF80.74
AMBN0.738
IRX60.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.434
GALNT9-0.415
SOHLH1-0.405
TESPA1-0.404
TMEM221-0.389
NEUROD2-0.374
NANOS3-0.37
EMX1-0.368
KCNC2-0.368
TBR1-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of GPR139 mRNA22230336
C006780bisphenol Abisphenol A results in decreased expression of GPR139 mRNA25181051
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GPR139 mRNA29097150
C008261lead acetatelead acetate results in decreased expression of GPR139 mRNA22641619
D010936Plant ExtractsPlant Extracts results in decreased expression of GPR139 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GPR139 mRNA21724226

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008188neuropeptide receptor activity-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IDA15845401  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal