Gene: HSF5

124535
HSF 5|HSTF 5
heat shock transcription factor 5
protein-coding
17q22
Ensembl:ENSG00000176160 Vega:OTTHUMG00000179078 UniprotKB:Q4G112
NC_000017.11
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.619e-2 (AD)  2.681e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs114903983chr17:58483499 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2F20.51
OR4D10.506
NEU20.503
ZAN0.5
POU5F20.497
DMRTC20.497
OR56A40.491
OR56A30.49
SLCO1B10.489
B3GNT60.485

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HOXD8-0.214
CBY3-0.185
CLDN23-0.183
C19orf33-0.183
POTEE-0.182
C1orf68-0.181
MYOD1-0.179
SMAD6-0.178
CDSN-0.178
ICOS-0.177

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A affects the methylation of HSF5 promoter27334623
C006780bisphenol Abisphenol A affects the expression of HSF5 mRNA25181051
D004041Dietary FatsDietary Fats results in decreased expression of HSF5 mRNA25016146
D000431EthanolEthanol results in increased expression of HSF5 mRNA20871982
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of HSF5 mRNA22634610
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of HSF5 mRNA22634610
C045463leflunomideleflunomide results in decreased expression of HSF5 mRNA19751817
C059539midostaurinmidostaurin results in increased expression of HSF5 mRNA20980353
C006253pirinixic acidpirinixic acid results in increased expression of HSF5 mRNA20813756
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HSF5 mRNA24058054
D015032ZincZinc deficiency results in decreased expression of HSF5 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0034605cellular response to heat-IBA21873635  
GO:0043618regulation of transcription from RNA polymerase II promoter in response to stress-IBA21873635  
GO:0061408positive regulation of transcription from RNA polymerase II promoter in response to heat stress-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal