Gene: USH1G

124590
ANKS4A|SANS
USH1 protein network component sans
protein-coding
17q25.1
Ensembl:ENSG00000182040 MIM:607696 Vega:OTTHUMG00000178864 UniprotKB:Q495M9
NG_007882.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.763e-2 (AD)  4.655e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENTHD10.747
MYO3A0.73
SAG0.729
IRX60.724
PRLR0.724
GPR1010.723
DRD30.718
TNFRSF80.713
GPR10.71
ZBED20.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.338
TBR1-0.328
SYTL2-0.314
TESPA1-0.306
ELAVL4-0.303
KCNC2-0.296
NEUROD2-0.292
GTDC1-0.284
GALNT9-0.283
PDE1A-0.278

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of USH1G mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of USH1G mRNA"23829299
D000393Air PollutantsAir Pollutants results in decreased expression of USH1G mRNA23649983
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of USH1G mRNA21298039
D001280AtrazineAtrazine results in increased expression of USH1G mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of USH1G gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of USH1G mRNA23735875
C018475butyraldehydebutyraldehyde results in increased expression of USH1G mRNA26079696
D003471CuprizoneCuprizone results in decreased expression of USH1G mRNA27523638
D004041Dietary FatsDietary Fats results in increased expression of USH1G mRNA25016146
C007738fluoranthenefluoranthene results in increased expression of USH1G mRNA20117838
C016517indole-3-carbinolindole-3-carbinol affects the expression of USH1G mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of USH1G mRNA26752646
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of USH1G mRNA24810058
C410127PCB 180PCB 180 results in increased expression of USH1G mRNA23829299
C046012pentanalpentanal results in increased expression of USH1G mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of USH1G mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of USH1G mRNA22298810
D014635Valproic AcidValproic Acid results in increased methylation of USH1G gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of USH1G gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12588794  19028668  20142502  27173435  
GO:0030507spectrin binding-IDA23704327  
GO:0042802identical protein binding-IPI20142502  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007605sensory perception of sound-IMP11398101  12588794  
GO:0042472inner ear morphogenesis-IEA-  
GO:0045494photoreceptor cell maintenance-IMP11398101  
GO:0050953sensory perception of light stimulus-IMP11398101  
GO:0050957equilibrioception-IMP12588794  
GO:0060122inner ear receptor cell stereocilium organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IEA-  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0015629actin cytoskeleton-ISS12588794  
GO:0032391photoreceptor connecting cilium-IEA-  
GO:0036064ciliary basal body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23665419Prenatal smoke exposure: effects on infant auditory system and placental gene expression. (2013 Jul-Aug)Katbamna BNeurotoxicol Teratol