Gene: ZPBP2

124626
ZPBPL
zona pellucida binding protein 2
protein-coding
17q21.1
Ensembl:ENSG00000186075 MIM:608499 Vega:OTTHUMG00000133022 UniprotKB:Q6X784
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.918e-1 (AD)  8.125e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRAC20.394
APCS0.386
C7orf650.372
OR13C80.359
DEFB1320.352
OR6C40.349
OR10D30.349
NLRP50.342
ASZ10.341
OR10J10.339

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRR19-0.213
CLEC4M-0.207
SKA1-0.205
FREM3-0.2
NPSR1-0.186
KNCN-0.184
ACMSD-0.184
CHRFAM7A-0.182
RIIAD1-0.181
KRTAP5-11-0.179

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of ZPBP2 mRNA17562736
C006780bisphenol Abisphenol A affects the expression of ZPBP2 mRNA25181051
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ZPBP2 mRNA"22485181
C082360fipronilfipronil results in increased expression of ZPBP2 mRNA23962444
C568376MT19c compoundMT19c compound results in decreased expression of ZPBP2 mRNA21781307
D010936Plant ExtractsPlant Extracts results in decreased expression of ZPBP2 mRNA23557933
D053260SootSoot results in increased expression of ZPBP2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZPBP2 mRNA21570461
D014635Valproic AcidValproic Acid results in increased methylation of ZPBP2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ZPBP2 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ZPBP2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ZPBP2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0001675acrosome assembly-IEA-  
GO:0007339binding of sperm to zona pellucida-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0002199zona pellucida receptor complex-IEA-  
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-HDA21630459  
GO:0044297cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2262659217q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. (2012 Jun)Marinho SAnn Allergy Asthma Immunol
2362200517q12-21 and asthma: interactions with early-life environmental exposures. (2013 May)Blekic MAnn Allergy Asthma Immunol