Gene: SLC43A2

124935
LAT4
solute carrier family 43 member 2
protein-coding
17p13.3
Ensembl:ENSG00000167703 MIM:610791 Vega:OTTHUMG00000090345 UniprotKB:Q8N370
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.151e-1 (AD)  3.649e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4790713chr17:1619583 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25212453chr17:1509953SLC43A21.400e-29Smoking27651444
cg21949830chr17:1510041SLC43A22.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF7460.889
EPS15L10.882
SPATA20.877
PI4K2A0.874
ASB60.872
LRRC410.872
TADA2B0.869
HM130.864
CHERP0.86
SLC35A20.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.515
OR4F29-0.458
CTNNA3-0.433
KLRB1-0.394
KLRK1-0.388
C9orf153-0.373
KLRC2-0.373
CETP-0.366
MTRNR2L9-0.357
MTRNR2L6-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5471242,3-dibromopropyl-2,4,6-tribromophenyl ether"2,3-dibromopropyl-2,4,6-tribromophenyl ether analog results in increased expression of SLC43A2 mRNA"25454221
D000082AcetaminophenAcetaminophen results in decreased expression of SLC43A2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of SLC43A2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC43A2 mRNA21641981
C000610085allyl 2,4,6-tribromophenyl ether"allyl 2,4,6-tribromophenyl ether results in increased expression of SLC43A2 mRNA"25454221
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC43A2 mRNA28522335
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins results in increased expression of SLC43A2 mRNA"23747718
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC43A2 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of SLC43A2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC43A2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC43A2 mRNA19770486|2222880
D004958EstradiolEstradiol results in decreased expression of SLC43A2 mRNA21185374
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of SLC43A2 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of SLC43A2 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC43A2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SLC43A2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC43A2 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of SLC43A2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of SLC43A2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC43A2 mRNA26472689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC43A2 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC43A2 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of SLC43A2 mRNA22300585
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC43A2 mRNA20599845
D019327Copper SulfateCopper Sulfate results in increased expression of SLC43A2 mRNA20599845
D016572CyclosporineCyclosporine results in decreased expression of SLC43A2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of SLC43A2 mRNA19770486
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC43A2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC43A2 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC43A2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SLC43A2 mRNA27594783
D000431EthanolEthanol results in increased expression of SLC43A2 mRNA28986285
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC43A2 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of SLC43A2 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of SLC43A2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC43A2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC43A2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC43A2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC43A2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SLC43A2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC43A2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SLC43A2 mRNA27392435
C045463leflunomideleflunomide results in increased expression of SLC43A2 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC43A2 mRNA20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SLC43A2 mRNA27544571
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of SLC43A2 mRNA25380136
C018620oleoresinsoleoresins results in decreased expression of SLC43A2 mRNA20008804
D010100OxygenOxygen deficiency results in decreased expression of SLC43A2 mRNA26516004
C005556propionaldehydepropionaldehyde results in increased expression of SLC43A2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC43A2 mRNA24780913
C017947sodium arsenitesodium arsenite affects the expression of SLC43A2 mRNA19590694
D012969Sodium FluorideSodium Fluoride results in decreased expression of SLC43A2 mRNA27862939
D012999SomanSoman results in increased expression of SLC43A2 mRNA19281266
D014284TriiodothyronineTriiodothyronine results in increased expression of SLC43A2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC43A2 mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC43A2 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC43A2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC43A2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SLC43A2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of SLC43A2 mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC43A2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SLC43A2 mRNA29024780
D014520UrethaneUrethane results in increased expression of SLC43A2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of SLC43A2 gene29154799
D014638VanadatesVanadates results in decreased expression of SLC43A2 mRNA22714537
D014640VancomycinVancomycin results in increased expression of SLC43A2 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of SLC43A2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015171amino acid transmembrane transporter activity-TAS-  
GO:0015175neutral amino acid transmembrane transporter activity-IBA21873635  
GO:0015179L-amino acid transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006865amino acid transport-TAS-  
GO:0015804neutral amino acid transport-IBA21873635  
GO:0015804neutral amino acid transport-IEA-  
GO:1902475L-alpha-amino acid transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-352230Amino acid transport across the plasma membraneTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal