Gene: ADH1B

125
ADH2|HEL-S-117
AD dehydrogenase 1B (class I), beta polypeptide
protein-coding
4q23
Ensembl:ENSG00000196616 MIM:103720 Vega:OTTHUMG00000161413 UniprotKB:P00325
NG_011435.1
PubMed|SNP Mapped
ND|AD
165   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.429e-1 (AD)  7.382e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1229984chr4:99318162 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1693457chr4:99315605 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1789882chr4:99313896 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2066702chr4:99307860 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C70.752
SLC16A120.711
CFH0.702
DCN0.691
STEAP40.689
TBX150.681
COL8A10.676
COL1A20.67
MGP0.654
ITGA10.649

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLRT1-0.537
RCOR2-0.52
CHRNA4-0.52
HAS1-0.515
MARCH4-0.513
NNAT-0.499
LRRC73-0.499
SPATA2L-0.497
SLC7A4-0.495
CORT-0.495

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB01213FomepizoleSmall Molecule7554-65-6ApprovedTarget
DB02481N-BenzylformamideSmall Molecule6343-54-0ExperimentalTarget
DB027214-IodopyrazoleSmall Molecule3469-69-0ExperimentalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB03703CyclohexanolSmall Molecule108-93-0ExperimentalTarget
DB04105N-HeptylformamideSmall MoleculeExperimentalTarget
DB09462GlycerinSmall Molecule56-81-5Approved|InvestigationalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
ID Drug Name Action PubMed
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA]27055685
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADH1B mRNA"27055685
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ADH1B protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ADH1B protein]26598702
C5444715-hydroxythalidomide5-hydroxythalidomide binds to ADH1B protein27464947
C0313909-cis-retinalADH1B protein results in increased metabolism of 9-cis-retinal17279314
D000079Acetaldehyde[ADH1B protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde15499379
D000079AcetaldehydeADH1B protein results in increased oxidation of Acetaldehyde23220590
D000079AcetaldehydeCimetidine inhibits the reaction [ADH1B protein results in increased oxidation of Acetaldehyde]23220590
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ADH1B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADH1B mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADH1B gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ADH1B mRNA21298039
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ADH1B protein]26598702
D001280AtrazineAtrazine results in increased expression of ADH1B mRNA25929836
D004958EstradiolEstradiol results in decreased expression of ADH1B mRNA20106945
D002927CimetidineCimetidine inhibits the reaction [ADH1B protein results in increased oxidation of Acetaldehyde]23220590
D002927CimetidineCimetidine inhibits the reaction [ADH1B protein results in increased oxidation of Ethanol]23220590
D016572CyclosporineCyclosporine results in decreased expression of ADH1B mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of ADH1B mRNA25047013
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of ADH1B mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of ADH1B mRNA26924002
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1B mRNA26159488
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1B protein26159488
D004726EndosulfanEndosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B protein]26159488
D004726EndosulfanEndosulfan results in decreased expression of ADH1B mRNA26159488
C118739entinostatentinostat results in decreased expression of ADH1B mRNA27188386
D000431EthanolADH1B gene polymorphism affects the susceptibility to Ethanol20171022|2296099
D000431EthanolADH1B protein results in increased metabolism of Ethanol15499379
D000431Ethanol[ADH1B protein results in increased metabolism of Ethanol] which results in increased chemical synthesis of Acetaldehyde15499379
D000431EthanolADH1B protein results in increased oxidation of Ethanol21167143|2322059
D000431EthanolCimetidine inhibits the reaction [ADH1B protein results in increased oxidation of Ethanol]23220590
D000431EthanolEthanol results in increased expression of ADH1B mRNA22056336
D000431Ethanolfomepizole inhibits the reaction [ADH1B protein results in increased oxidation of Ethanol]21167143
D000431Ethanolresveratrol inhibits the reaction [Ethanol results in increased expression of ADH1B mRNA]22056336
D019855Ethylene GlycolADH1B protein results in increased oxidation of Ethylene Glycol21167143
C082360fipronilfipronil results in decreased expression of ADH1B mRNA27091632
C010238fomepizolefomepizole inhibits the reaction [ADH1B protein results in increased oxidation of Ethanol]21167143
D007854LeadLead results in decreased expression of ADH1B mRNA19921347
C045463leflunomideleflunomide results in decreased expression of ADH1B mRNA28988120
D000432MethanolADH1B protein results in increased oxidation of Methanol21167143
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ADH1B mRNA27055685
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of ADH1B mRNA26924002
D009532NickelNickel results in decreased expression of ADH1B mRNA25583101
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ADH1B mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ADH1B mRNA27153767
D010634PhenobarbitalPhenobarbital results in decreased expression of ADH1B mRNA19084549
D011374ProgesteroneProgesterone results in increased expression of ADH1B mRNA20864642|2179573
D0198402-PropanolADH1B protein results in increased oxidation of 2-Propanol21167143
C059514resveratrolresveratrol inhibits the reaction [Ethanol results in increased expression of ADH1B mRNA]22056336
D012172RetinaldehydeADH1B protein results in increased metabolism of Retinaldehyde17279314
D012643SeleniumSelenium results in decreased expression of ADH1B mRNA19244175
D014284TriiodothyronineTriiodothyronine results in decreased expression of ADH1B mRNA15507505
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA]27055685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA]27055685
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1B mRNA26159488
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH1B protein26159488
D013749TetrachlorodibenzodioxinEndosulfan promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH1B protein]26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH1B mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH1B protein26159488
D013849ThimerosalThimerosal results in decreased expression of ADH1B mRNA27188386
D014212TretinoinADH1B protein results in increased metabolism of Tretinoin17279314
C057693troglitazonetroglitazone results in decreased expression of ADH1B mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of ADH1B mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of ADH1B gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ADH1B mRNA28001369
D014752Vinyl ChlorideADH1B gene polymorphism results in increased susceptibility to Vinyl Chloride16270392
C111237vorinostatvorinostat results in decreased expression of ADH1B mRNA27188386
C574123walrycin Awalrycin A results in increased expression of ADH1B mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004024alcohol dehydrogenase activity, zinc-dependent-EXP9982  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-IDA9982  
GO:0008270zinc ion binding-IDA9982  
GO ID GO Term Qualifier Evidence PubMed
GO:0006069ethanol oxidation-IDA2398055  
GO:0006069ethanol oxidation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29063269Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. (2018 May)Yokoyama AJ Gastroenterol
28937693Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)Clarke TKMol Psychiatry
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
25365528ALDH2*2 but not ADH1B*2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: correlation of the pharmacokinetic and pharmacodynamic findings. (2014 Dec)Peng GSPharmacogenet Genomics
26033520Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese. (2015 Aug)Chang YHBipolar Disord
24093763Genetic variant of single-nucleotide polymorphism is associated with risk of esophageal squamous cell carcinoma. (2014 Jan)Ye BGenet Test Mol Biomarkers
21284671Acetaldehyde burst protection of ADH1B*2 against alcoholism: an additional hormesis protection against esophageal cancers following alcohol consumption? (2011 May)Israel YAlcohol Clin Exp Res
29582627ADH1B, ALDH2, GSTM1 and GSTT1 Gene Polymorphic Frequencies among Alcoholics and Controls in the Arcadian Population of Central India (2018 Mar 27)Mansoori AAAsian Pac J Cancer Prev
21351086Shortened telomeres in individuals with abuse in alcohol consumption. (2011 Aug 15)Pavanello SInt J Cancer
12244546Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish population. (2002 Oct 1)Carr LGAm J Med Genet
17134659Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population. (2006 Jun)Montano Loza AJAlcohol
15957670Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans. (2005 Mar)Cook TAJ Stud Alcohol
25208201Subjective response to alcohol and ADH polymorphisms in a select sample of young adult male East Indians and Africans in Trinidad and Tobago. (2014 Sep)Montane Jaime LKJ Stud Alcohol Drugs
25874489Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma. (2015 Jun)Ji YBTumour Biol
27172571Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms. (2016 May)Chartier KGJ Stud Alcohol Drugs
28361821Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov)Malhotra SIndian J Med Res
15066702Workshop on Alcohol Use and Health Disparities 2002: a call to arms. (2004 Jan)Russo DAlcohol
16930209Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians. (2006 Sep)Duranceaux NCAlcohol Clin Exp Res
20626721Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. (2011 Apr)Preuss UWAddict Biol
28485404Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. (2017 Sep)Jorgenson EMol Psychiatry
25427912Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. (2015)Yokoyama AAdv Exp Med Biol
24889829Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes. (2014 Sep)Zhang HHum Genet
26042511Genetic polymorphisms of ADH1B, ADH1C and ALDH2 in Turkish alcoholics: lack of association with alcoholism and alcoholic cirrhosis. (2015 May 17)Vatansever SBosn J Basic Med Sci
26863581Ethanol-metabolizing activities and isozyme protein contents of alcohol and aldehyde dehydrogenases in human liver: phenotypic traits of the ADH1B*2 and ALDH2*2 variant gene alleles. (2016 Feb 9)Chiang CPPharmacogenet Genomics
22004471Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. (2012 Jan)Frank JAddict Biol
17207821Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. (2007 Feb 3)Ishikawa HMutat Res
28610454Genetic polymorphisms of alcohol-metabolizing enzymes and their association with alcoholism risk, personality and anthropometric traits among Malaysian university students. (2018 Feb)Ong HHPsychol Health Med
26992901Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction. (2016 Jun)Masaoka HCarcinogenesis
21900886Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. (2012 Jan)Ray LANeuropsychopharmacology
22325912Determination of the effects of alcohol dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey. (2012 Mar)Aktas EOSci Justice
22150722ADH1B polymorphism, alcohol consumption, and binge drinking in Slavic Caucasians: results from the Czech HAPIEE study. (2012 May)Hubacek JAAlcohol Clin Exp Res
12050823A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. (2002 Jul)Osier MVAm J Hum Genet
17180580Haplotype analysis at the alcohol dehydrogenase gene region in New Zealand Maori. (2007)Hall DAJ Hum Genet
21576033ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population. (2011 Jul)Ji YBOral Oncol
25660313Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)Forero DADrug Alcohol Depend
16600530Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. (2006 Sep 15)Lorenzo ADrug Alcohol Depend
28714907Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. (2017 Jul 17)Treutlein JGenes (Basel)
24735490Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. (2015 May)Way MAddict Biol
16385178Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. (2005 Dec)Han YAlcohol Clin Exp Res
27450204Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. (2016 Jul 22)Mao NWorld J Surg Oncol
19193628ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (2009 Apr 15)Birley AJHum Mol Genet
15564879Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism. (2004 Nov)Lee SLPharmacogenetics
21432543Effect of gene polymorphisms and ethanol consumption on micronucleus frequency in human reticulocytes: a preliminary study. (2010 May)Wu CEnviron Health Prev Med
17285601Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (2007 May)Matsuo KHum Mutat
23414439Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men. (2013 Jul)Yokoyama AAlcohol Clin Exp Res
17273965Evidence of positive selection on a class I ADH locus. (2007 Mar)Han YAm J Hum Genet
15048643Possible epistatic role of ADH7 in the protection against alcoholism. (2004 Apr 1)Osier MVAm J Med Genet B Neuropsychiatr Genet
18299763Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. (2008 Mar)Duranceaux NCJ Stud Alcohol Drugs
27187070Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women. (2016 Oct)Polimanti RNeuropsychopharmacology
25102261Maternal folate, alcohol and energy metabolism-related gene polymorphisms and the risk of recurrent pregnancy loss. (2012 Oct)Sata FJ Dev Orig Health Dis
21168396Variation in the ADH1B proximal promoter affects expression. (2011 May 30)Pochareddy SChem Biol Interact
16385179No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. (2005 Dec)Lu RBAlcohol Clin Exp Res
26842247Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. (2016 Feb)Wu LSAlcohol Clin Exp Res
22690706Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain). (2012 Dec)Munoz XAddiction
17923853Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. (2008 Jun)Tolstrup JSPharmacogenomics J
19710201Mechanism of protection against alcoholism by an alcohol dehydrogenase polymorphism: development of an animal model. (2010 Jan)Rivera-Meza MFASEB J
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res
24553426Alcohol consumption and cognitive impairment in older men: a mendelian randomization study. (2014 Mar 25)Almeida OPNeurology
23134050Genes encoding enzymes involved in ethanol metabolism. (2012)Hurley TDAlcohol Res
27338962Genetics of Substance Use Disorders. (2016 Jul)Yu CChild Adolesc Psychiatr Clin N Am
21187698Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians. (2010)Yokoyama AKeio J Med
17718395Variations in ADH and ALDH in Southwest California Indians. (2007)Ehlers CLAlcohol Res Health
17718396Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. (2007)Scott DMAlcohol Res Health
17718397ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. (2007)Eng MYAlcohol Res Health
17718398Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago. (2007)Moore SAlcohol Res Health
28349588ADH1B: From alcoholism, natural selection, and cancer to the human phenome. (2018 Mar)Polimanti RAm J Med Genet B Neuropsychiatr Genet
21917409Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers. (2012 Feb)Pavanello SAlcohol
23456092Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)Park BLHum Genet
16086315Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism. (2005 Sep)Choi IGHum Mutat
18056758Major genetic components underlying alcoholism in Korean population. (2008 Mar 15)Kim DJHum Mol Genet
26917006Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men. (2016 Mar)Yokoyama AAlcohol Clin Exp Res
17559546Effect of ADH1B genotype on alcohol consumption in young Israeli Jews. (2007 Aug)Spivak BAlcohol Clin Exp Res
29084628First description and evaluation of SNPs in the ADH and ALDH genes in a population of alcoholics in Central-West Brazil. (2017 Dec)Teixeira TMAlcohol
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
27986911Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation. (2017 Sep 1)Masaoka HNicotine Tob Res
19403456Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. (2009 Apr)Vaswani MHum Genomics
17850643Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population. (2007 Oct)Fischer MAlcohol Clin Exp Res
20714161Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. (2010)Mustavich LFHum Hered
12500098A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans. (2002 Dec)Osier MVAlcohol Clin Exp Res
22214999Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer. (2012 Mar-Apr)Rivera-Meza MAlcohol Alcohol
21968928ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. (2012 Apr)Bierut LJMol Psychiatry
23134043Identifying genetic variation for alcohol dependence. (2012)Agrawal AAlcohol Res
23296215Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism. (2013 Mar-Apr)Yokoyama AAlcohol Alcohol
27038040ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. (2016 Jul)Kagemoto KCancer Med
26924531Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. (2016 Mar 3)Galinsky KJAm J Hum Genet
20477764ADH1B*3 and response to alcohol in African-Americans. (2010 Jul)McCarthy DMAlcohol Clin Exp Res
20477767Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. (2010 Jul)Yokoyama AAlcohol Clin Exp Res
23550892Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. (2013 Aug)Yokoyama AAlcohol Clin Exp Res
28921935Assessing causal relationships using genetic proxies for exposures: an introduction to Mendelian randomization. (2018 Apr)Katikireddi SVAddiction
23701534Genetic instrumental variable studies of effects of prenatal risk factors. (2013)Wehby GLBiodemography Soc Biol
17847010Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. (2007 Oct)Li HAm J Hum Genet
22155604The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese. (2011 Oct)Yao CTHum Genomics
17250612Association of the ADHIB*3 allele with alcohol-related phenotypes in Trinidad. (2007 Feb)Ehlers CLAlcohol Clin Exp Res
16184481Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. (2005 Sep)Birley AJBehav Genet
23176670High diversity and no significant selection signal of human ADH1B gene in Tibet. (2012 Nov 23)Lu YInvestig Genet
21848961Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism. (2011 Nov)Kimura MAlcohol Clin Exp Res
17071628Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. (2007 Apr)Asakage TCarcinogenesis
25271825Asian flushing: genetic and sociocultural factors of alcoholism among East asians. (2014 Sep-Oct)Lee HGastroenterol Nurs
29166882Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India. (2017 Nov 22)Ghosh SBMC Cancer
17590986Acetaldehyde, polymorphisms and the cardiovascular system. (2007)Yin SJNovartis Found Symp
19698717Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (2009 Nov)Cui RGastroenterology
24797321Effect of the allelic variant of alcohol dehydrogenase ADH1B*2 on ethanol metabolism. (2014 Jun)Kang GAlcohol Clin Exp Res
19262484Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. (2009 Mar)Tsuchihashi-Makaya MHypertens Res
17185388Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (2007 Feb 15)Luo XHum Mol Genet
20219057ADH1B*2 allele is protective against alcoholism but not chronic liver disease in the Hungarian population. (2010 May)Toth RAddiction
24220019Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. (2014 Aug)Enoch MAPharmacol Biochem Behav
29423536Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk. (2018 Feb 8)Abiko SJ Gastroenterol
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
17718394The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (2007)Edenberg HJAlcohol Res Health
19164089Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. (2009 Jan)Peng GSHum Genomics
25410943The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men. (2014 Dec)Sartor CEAlcohol Clin Exp Res
19298322Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. (2009 May)Sherva RAlcohol Clin Exp Res
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