Gene: TTC39C

125488
C18orf17|HsT2697
tetratricopeptide repeat domain 39C
protein-coding
18q11.2
Ensembl:ENSG00000168234 Vega:OTTHUMG00000179403 UniprotKB:Q8N584
NC_000018.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.305e-1 (AD)  3.615e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2305024chr18:24082852 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHTF10.904
FGFR1OP0.895
NIPAL20.895
BRAF0.895
LRFN50.892
IPCEF10.891
FSTL40.891
PRRG30.89
AAK10.888
MARK10.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.488
COPZ2-0.486
HEY2-0.481
MYOM1-0.476
YES1-0.466
RHOD-0.461
ASB4-0.45
CNN2-0.44
MBNL3-0.435
REST-0.433

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TTC39C mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of TTC39C mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TTC39C protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TTC39C mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TTC39C gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TTC39C mRNA19770486
D000452AldrinAldrin results in increased expression of TTC39C mRNA18579281
D001280AtrazineAtrazine results in increased expression of TTC39C mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTC39C mRNA21632981|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTC39C mRNA21569818
D004958EstradiolEstradiol results in decreased expression of TTC39C mRNA20106945
C006780bisphenol Abisphenol A affects the expression of TTC39C mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TTC39C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TTC39C gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of TTC39C mRNA27339419
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TTC39C mRNA24763279
D002737ChloropreneChloroprene results in increased expression of TTC39C mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TTC39C mRNA28472532
D019327Copper SulfateCopper Sulfate results in decreased expression of TTC39C mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TTC39C mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of TTC39C mRNA19770486
C093628cyproconazolecyproconazole results in decreased expression of TTC39C mRNA22334560
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TTC39C mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of TTC39C mRNA25047013
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of TTC39C mRNA28962523
D002945CisplatinCisplatin results in increased expression of TTC39C mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of TTC39C mRNA22609946
D002117CalcitriolCalcitriol results in increased expression of TTC39C mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of TTC39C mRNA21592394
C109476epoxiconazoleepoxiconazole results in decreased expression of TTC39C mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TTC39C mRNA17555576
C024565ethylene dichlorideethylene dichloride results in decreased expression of TTC39C mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TTC39C mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of TTC39C mRNA23649840
D005897GlafenineGlafenine results in decreased expression of TTC39C mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of TTC39C mRNA24763279
D017313FenretinideFenretinide results in decreased expression of TTC39C mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of TTC39C mRNA28201806
C410337K 7174K 7174 results in decreased expression of TTC39C mRNA24086573
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TTC39C mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TTC39C mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TTC39C mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TTC39C mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TTC39C mRNA"25554681
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of TTC39C mRNA26705709
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TTC39C mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of TTC39C mRNA19482888|2309116
C006253pirinixic acidpirinixic acid results in decreased expression of TTC39C mRNA23811191
C045950propiconazolepropiconazole results in decreased expression of TTC39C mRNA21278054|2233456
D011794QuercetinQuercetin results in decreased expression of TTC39C mRNA21632981
C017947sodium arsenitesodium arsenite affects the expression of TTC39C mRNA29319823
D053260SootSoot results in increased expression of TTC39C mRNA26551751
D013629TamoxifenTamoxifen affects the expression of TTC39C mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of TTC39C mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TTC39C mRNA21592394
D013739TestosteroneTestosterone results in increased expression of TTC39C mRNA20844152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TTC39C mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTC39C mRNA19770486|2892240
D013849Thimerosal"[NOG protein co-treated with Thimerosal co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of TTC39C mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of TTC39C mRNA27760801
D014212TretinoinTretinoin results in decreased expression of TTC39C mRNA23724009
D014241TrichloroethyleneTrichloroethylene affects the expression of TTC39C mRNA21135412
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TTC39C mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of TTC39C mRNA28973697
D014520UrethaneUrethane results in decreased expression of TTC39C mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTC39C mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of TTC39C gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TTC39C mRNA26272509
C088658zoledronic acidzoledronic acid results in increased expression of TTC39C mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal