Gene: CNGB1

1258
CNCG2|CNCG3L|CNCG4|CNG4|CNGB1B|GAR1|GARP|GARP2|RCNC2|RCNCb|RCNCbeta|RP45
cyclic nucleotide gated channel beta 1
protein-coding
16q21
Ensembl:ENSG00000070729 MIM:600724 Vega:OTTHUMG00000154810 UniprotKB:Q14028
NG_016351.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.860e-1 (AD)  9.299e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HTR1A0.854
FAM163A0.838
GLRA30.823
IGSF30.821
HS6ST30.814
PCDH190.811
FFAR40.804
CUX20.804
PCDH80.801
GPR260.791

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAYN-0.533
CPM-0.532
RHOG-0.513
FAM107B-0.51
TGFB3-0.51
BCAS1-0.506
SLC35D2-0.498
HEY2-0.494
CTNNA3-0.493
LITAF-0.485

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CNGB1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CNGB1 mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CNGB1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNGB1 mRNA16483693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CNGB1 mRNA26377693
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CNGB1 mRNA20823114
C006780bisphenol Abisphenol A results in decreased expression of CNGB1 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of CNGB1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of CNGB1 mRNA27523638
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CNGB1 mRNA20823114
D002117CalcitriolCalcitriol results in increased expression of CNGB1 mRNA16002434
D004317DoxorubicinDoxorubicin results in decreased expression of CNGB1 mRNA19915844
D018120FinasterideFinasteride results in decreased expression of CNGB1 mRNA24136188
C069837fullerene C60fullerene C60 results in decreased expression of CNGB1 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of CNGB1 mRNA22061828
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CNGB1 mRNA23430699
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of CNGB1 mRNA20823114
C028007nickel monoxidenickel monoxide results in decreased expression of CNGB1 mRNA19167457
C078903seocalcitolseocalcitol results in increased expression of CNGB1 mRNA12040012
D013467SulindacSulindac results in decreased expression of CNGB1 mRNA24136188
D013748TetracaineTetracaine results in decreased activity of [CNGA1 protein binds to CNGB1 protein]21634421
D014635Valproic AcidValproic Acid affects the expression of CNGB1 mRNA17963808
C025643vinclozolinvinclozolin affects the expression of CNGB1 mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of CNGB1 mRNA19244175
D015032ZincZinc deficiency results in increased expression of CNGB1 mRNA18356318
C088658zoledronic acidzoledronic acid results in increased expression of CNGB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005222intracellular cAMP activated cation channel activity-IBA21873635  
GO:0005222intracellular cAMP activated cation channel activity-IEA-  
GO:0005223intracellular cGMP activated cation channel activity-IBA21873635  
GO:0005223intracellular cGMP activated cation channel activity-IDA24164424  
GO:0005515protein binding-IPI20890309  
GO:0015276ligand-gated ion channel activity-TAS7682292  
GO:0030552cAMP binding-IEA-  
GO:0030553cGMP binding-IBA21873635  
GO:0030553cGMP binding-IDA24164424  
GO ID GO Term Qualifier Evidence PubMed
GO:0001895retina homeostasis-IMP15557452  
GO:0006812cation transport-IDA24164424  
GO:0007601visual perception-TAS7682292  
GO:0007608sensory perception of smell-IEA-  
GO:0016056rhodopsin mediated signaling pathway-TAS-  
GO:0022400regulation of rhodopsin mediated signaling pathway-TAS-  
GO:0033365protein localization to organelle-IEA-  
GO:0035845photoreceptor cell outer segment organization-IEA-  
GO:0045494photoreceptor cell maintenance-IEA-  
GO:0050908detection of light stimulus involved in visual perception-IMP15557452  
GO:0051290protein heterotetramerization-IEA-  
GO:0051480regulation of cytosolic calcium ion concentration-IEA-  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0001750photoreceptor outer segment-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0017071intracellular cyclic nucleotide activated cation channel complex-IEA-  
GO:0030660Golgi-associated vesicle membrane-TAS-  
GO:0043195terminal bouton-IEA-  
GO:0060170ciliary membrane-TAS-  
GO:1902495transmembrane transporter complex-IDA24164424  
KEGG ID KEGG Term
hsa04740Olfactory transduction
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-2187338Visual phototransductionTAS
R-HSA-2485179Activation of the phototransduction cascadeTAS
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5617833Cilium AssemblyIEA
R-HSA-5620916VxPx cargo-targeting to ciliumTAS
R-HSA-5620916VxPx cargo-targeting to ciliumIEA
R-HSA-5620920Cargo trafficking to the periciliary membraneTAS
R-HSA-5620920Cargo trafficking to the periciliary membraneIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25821920Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking. (2015 Jun)Metzler-Guillemain CSyst Biol Reprod Med