Gene: OSCAR

126014
PIGR3|PIgR-3
osteoclast associated, immunoglobulin-like receptor
protein-coding
19q13.42
Ensembl:ENSG00000170909 MIM:606862 Vega:OTTHUMG00000064966 UniprotKB:Q8IYS5
NC_000019.10
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.855e-1 (AD)  4.037e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STXBP20.814
C20.81
ABI30.787
TLR20.786
RNASET20.783
CD680.782
WAS0.78
DEF60.777
IRF50.774
SPI10.769

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.352
HES5-0.351
ARSF-0.332
CPLX3-0.33
PYGM-0.29
HPSE2-0.283
WNT7A-0.282
MMD2-0.281
KIT-0.272
DIO2-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of OSCAR mRNA17562736
C006632arsenic trioxidearsenic trioxide results in decreased expression of OSCAR mRNA19128835
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of OSCAR gene28505145
C006780bisphenol Abisphenol A results in decreased expression of OSCAR mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of OSCAR mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of OSCAR mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of OSCAR mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of OSCAR mRNA25562108
D002945CisplatinCisplatin results in increased expression of OSCAR mRNA27594783
D005557FormaldehydeFormaldehyde results in decreased expression of OSCAR mRNA28937961
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of OSCAR gene28505145
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OSCAR mRNA25613284
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with CSF1 protein] results in increased expression of OSCAR protein21127049
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of OSCAR promoter18448484
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of OSCAR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of OSCAR mRNA"25620056
D009532NickelNickel results in increased expression of OSCAR mRNA24768652|2558310
D009534NiclosamideNiclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]26792726
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of OSCAR mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of OSCAR mRNA"18204070
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OSCAR mRNA19710929
C005556propionaldehydepropionaldehyde results in increased expression of OSCAR mRNA26079696
D012402RotenoneRotenone inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]19900598
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of OSCAR mRNA23806026
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of OSCAR promoter18448484
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of OSCAR mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of OSCAR mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of OSCAR mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of OSCAR gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0038064collagen receptor activity-IDA21841309  
GO:0038064collagen receptor activity-IMP21841309  
GO ID GO Term Qualifier Evidence PubMed
GO:0030316osteoclast differentiation-IMP21841309  
GO:0038065collagen-activated signaling pathway-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0035580specific granule lumen-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15057947The impact of correcting for smoking status when screening for chromosomal anomalies using maternal serum biochemistry and fetal nuchal translucency thickness in the first trimester of pregnancy. (2004 Mar)Spencer KPrenat Diagn