Gene: CNGA3

1261
ACHM2|CCNC1|CCNCa|CCNCalpha|CNCG3|CNG3
cyclic nucleotide gated channel alpha 3
protein-coding
2q11.2
Ensembl:ENSG00000144191 MIM:600053 Vega:OTTHUMG00000130561 UniprotKB:Q16281
NG_009097.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.794e-1 (AD)  4.354e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10865016chr2:98372841 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPC60.643
C3orf520.634
RAB11FIP10.628
PLEKHS10.599
FNDC10.597
DRAXIN0.593
PPARG0.592
ITK0.57
TNFSF180.565
FST0.557

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FEZF2-0.373
KIAA1755-0.293
MOBP-0.273
MBP-0.272
PAIP2B-0.27
KIF19-0.265
DAPK2-0.26
SMYD1-0.256
SLCO1A2-0.25
UNC5CL-0.249

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CNGA3 mRNA"20406850
D000082AcetaminophenAcetaminophen results in increased expression of CNGA3 mRNA26690555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNGA3 mRNA16483693
D001151ArsenicArsenic affects the methylation of CNGA3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNGA3 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of CNGA3 mRNA25181051
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of CNGA3 mRNA27935865
C025256nonylphenolnonylphenol results in increased expression of CNGA3 mRNA22982499
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of CNGA3 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of CNGA3 mRNA12832660
D059808PolyphenolsPolyphenols results in decreased expression of CNGA3 mRNA16293270
D014635Valproic AcidValproic Acid results in increased expression of CNGA3 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005222intracellular cAMP activated cation channel activity-IBA21873635  
GO:0005223intracellular cGMP activated cation channel activity-IBA21873635  
GO:0005223intracellular cGMP activated cation channel activity-IMP24164424  
GO:0008022protein C-terminus binding-IEA-  
GO:0015276ligand-gated ion channel activity-TAS9517456  
GO:0030553cGMP binding-IBA21873635  
GO:0030553cGMP binding-IMP24164424  
GO ID GO Term Qualifier Evidence PubMed
GO:0006812cation transport-IMP24164424  
GO:0007165signal transduction-TAS9517456  
GO:0007601visual perception-IEA-  
GO:0031960response to corticosteroid-IEA-  
GO:0032026response to magnesium ion-IEA-  
GO:0051591response to cAMP-IEA-  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0030425dendrite-IEA-  
GO:0042622photoreceptor outer segment membrane-IEA-  
GO:0043204perikaryon-IEA-  
GO:1902495transmembrane transporter complex-IDA24164424  
KEGG ID KEGG Term
hsa04740Olfactory transduction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal