Gene: NLRP5

126206
CLR19.8|MATER|NALP5|PAN11|PYPAF8
NLR family pyrin domain containing 5
protein-coding
19q13.43
Ensembl:ENSG00000171487 MIM:609658 Vega:OTTHUMG00000149887 UniprotKB:P59047
NG_046924.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.075e-1 (AD)  2.962e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16986899chr19:56038144 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs4801658chr19:56004228 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BAGE20.775
DAOA0.764
CRISP10.763
OR8H10.763
OR5M100.757
OR5AS10.757
OR1S20.756
TCHHL10.754
C11orf440.752
DEFB1180.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRB2-0.246
HHATL-0.238
C1orf134-0.231
ARSI-0.226
PCDH9-0.21
TMEM221-0.202
C6orf52-0.202
ADCY2-0.201
HDAC11-0.193
TM7SF2-0.188

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NLRP5 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NLRP5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NLRP5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NLRP5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NLRP5 mRNA"25510870
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of NLRP5 mRNA20660070
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of NLRP5 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NLRP5 mRNA25181051
D004041Dietary FatsDietary Fats results in decreased expression of NLRP5 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of NLRP5 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NLRP5 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of NLRP5 mRNA"21785161
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of NLRP5 mRNA"27840820
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of NLRP5 mRNA22634610
C008261lead acetatelead acetate results in increased expression of NLRP5 mRNA22613225
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NLRP5 mRNA"24972896
D008727MethotrexateMethotrexate affects the expression of NLRP5 mRNA18502557
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NLRP5 mRNA"25510870
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of NLRP5 mRNA20660070
C005556propionaldehydepropionaldehyde results in decreased expression of NLRP5 mRNA26079696
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NLRP5 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NLRP5 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of NLRP5 mRNA26496021

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0070997neuron death-IMP22166940  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-ISS-  
GO:0005739mitochondrion-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal