Gene: PLK5

126520
PLK-5|PLK5P|SgK384ps
polo like kinase 5
protein-coding
19p13.3
Ensembl:ENSG00000185988 Vega:OTTHUMG00000180073 UniprotKB:Q496M5
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.929e-1 (AD)  5.990e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2292453chr19:1526471 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNFRSF250.771
FGF170.768
ZGLP10.752
RCE10.75
MOK0.739
NELFA0.729
PTCH20.726
ATXN7L20.722
CCDC1200.721
STK360.712

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM37-0.39
GZMA-0.385
CD48-0.382
ARHGEF35-0.38
DNASE1L3-0.378
VRK2-0.369
SH2D1A-0.369
AOX1-0.369
CTNNA3-0.367
DTHD1-0.367

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PLK5 mRNA"26377693
D020106AcrylamideAcrylamide results in decreased expression of PLK5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLK5 mRNA23630614
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLK5 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLK5 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLK5 mRNA27858113
C006780bisphenol Abisphenol A affects the expression of PLK5 mRNA25181051
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PLK5 mRNA27858113
D003471CuprizoneCuprizone results in increased expression of PLK5 mRNA26577399
C069837fullerene C60fullerene C60 results in increased expression of PLK5 mRNA19167457
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLK5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLK5 mRNA"25554681|2562005
C006253pirinixic acidpirinixic acid results in decreased expression of PLK5 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLK5 mRNA24780913
D012999SomanSoman results in decreased expression of PLK5 mRNA19281266
C009495titanium dioxidetitanium dioxide affects the expression of PLK5 mRNA23557971
D014635Valproic AcidValproic Acid results in increased methylation of PLK5 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLK5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002357defense response to tumor cell-IDA21245385  
GO:0006468protein phosphorylation-IEA-  
GO:0007049cell cycle-IEA-  
GO:0010976positive regulation of neuron projection development-IDA21245385  
GO:0042981regulation of apoptotic process-IMP21245385  
GO:0051301cell division-IEA-  
GO:0071363cellular response to growth factor stimulus-IDA21245385  
GO:2000045regulation of G1/S transition of mitotic cell cycle-IMP21245385  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IDA21245385  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal