Gene: CNP

1267
CNP1
2',3'-cyclic nucleotide 3' phosphodiesterase
protein-coding
17q21.2
Ensembl:ENSG00000173786 MIM:123830 Vega:OTTHUMG00000133502 UniprotKB:P09543
NC_000017.11
PubMed
0   ANCO-SNPs
CD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.427e-1 (AD)  1.911e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13917614chr17:40125660CNP2.500e-8Smoking27651444
cg13917614chr17:40125660CNP4.450e-10Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DBNDD20.941
MAG0.926
MOG0.925
PLP10.918
PLLP0.917
CLDND10.913
ELOVL10.91
PIP4K2A0.91
SLC44A10.909
TF0.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.53
OR4F5-0.498
CNGB1-0.317
CUX2-0.311
NPBWR1-0.304
CHRNA2-0.296
PAX2-0.295
LTK-0.292
SHISA8-0.288
SP8-0.286

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of CNP protein"21673325
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CNP mRNA"19114083
C0122672,4-D n-butyl ester"2,4-D n-butyl ester results in decreased activity of CNP protein"2995884
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CNP mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CNP mRNA"25380136
D000324Adrenocorticotropic HormoneAdrenocorticotropic Hormone results in decreased activity of CNP protein3030154
D000638AmiodaroneAmiodarone results in increased expression of CNP mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNP mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of CNP protein16483693
C023650anilineaniline results in decreased expression of CNP protein20233944
D001280AtrazineAtrazine results in increased expression of CNP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CNP mRNA26001963
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CNP mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CNP mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CNP mRNA22228805
C006780bisphenol Abisphenol A results in increased methylation of CNP promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of CNP mRNA25084756
C006780bisphenol Abisphenol A results in decreased expression of CNP protein25084756
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CNP mRNA25993096
D019256Cadmium Chloride[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of CNP protein23680456
D002235CarbofuranCarbofuran results in decreased expression of CNP mRNA28982980
D003024ClozapineClozapine results in decreased expression of CNP mRNA17266109
D003024ClozapineClozapine results in increased expression of CNP mRNA17266109
D003300CopperCopper results in decreased expression of CNP mRNA26293553
D019327Copper SulfateCopper Sulfate results in decreased expression of CNP mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of CNP mRNA26577399|2752363
D003471CuprizoneCuprizone results in decreased expression of CNP protein26577399|2752363
D003471CuprizoneCuprizone results in increased expression of CNP mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of CNP mRNA25562108
D0150842,4-Dichlorophenoxyacetic Acid"2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein"18460445
D013759DronabinolDronabinol results in decreased expression of CNP mRNA16616335
D003907DexamethasoneDexamethasone results in decreased expression of CNP mRNA19853640
D003976DiazinonDiazinon results in increased methylation of CNP gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CNP mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CNP mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CNP mRNA21266533
D002945CisplatinCisplatin results in increased expression of CNP mRNA21151649
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CNP mRNA25380136
D004050DitiocarbDitiocarb results in increased expression of CNP protein22874009
C069837fullerene C60fullerene C60 results in decreased expression of CNP mRNA19167457
D006220HaloperidolHaloperidol results in decreased expression of CNP mRNA17177202
D017313FenretinideFenretinide results in decreased expression of CNP mRNA28973697
C410337K 7174K 7174 results in decreased expression of CNP mRNA24086573
C008261lead acetatelead acetate results in decreased expression of CNP protein20797405
C008261lead acetate[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of CNP protein23680456
C045463leflunomideleflunomide results in decreased expression of CNP mRNA28988120
D001556LindaneLindane results in decreased activity of CNP protein1701514
D008767Methylmercury CompoundsMethylmercury Compounds affects the splicing of CNP mRNA25936639
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CNP mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CNP mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CNP mRNA25380136
C016030pantogabpantogab results in decreased expression of CNP mRNA17379144
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of CNP mRNA27294297
D010416PentachlorophenolPentachlorophenol results in increased expression of CNP mRNA24642059
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CNP protein26879310
D010622PhencyclidinePhencyclidine results in decreased expression of CNP mRNA17266109
D010622PhencyclidinePhencyclidine results in increased expression of CNP mRNA17266109
D011374ProgesteroneProgesterone results in increased expression of CNP mRNA19853640
C045950propiconazolepropiconazole results in decreased expression of CNP mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of CNP mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CNP mRNA21427059
D018030Silver CompoundsSilver Compounds results in decreased expression of CNP protein27427492
D018030Silver CompoundsSilver Compounds results in increased expression of CNP mRNA27427492
C017947sodium arsenite[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in decreased expression of CNP protein23680456
C016104sodium bichromatesodium bichromate affects the expression of CNP mRNA22110744
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CNP mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CNP mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CNP mRNA28065790
D014212TretinoinTretinoin results in increased expression of CNP mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CNP mRNA"26179874
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of CNP mRNA18422935
D014635Valproic AcidValproic Acid results in decreased expression of CNP mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of CNP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CNP mRNA21427059
D014638VanadatesVanadates results in decreased expression of CNP mRNA22714537
C025643vinclozolinvinclozolin results in increased expression of CNP mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:00041132',3'-cyclic-nucleotide 3'-phosphodiesterase activity-IBA21873635  
GO:0030551cyclic nucleotide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IEA-  
GO:0007268chemical synaptic transmission-TAS1322358  
GO:0007409axonogenesis-IEA-  
GO:0007568aging-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0009214cyclic nucleotide catabolic process-IEA-  
GO:0009636response to toxic substance-IEA-  
GO:0021762substantia nigra development-HEP22926577  
GO:0030900forebrain development-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0046902regulation of mitochondrial membrane permeability-IEA-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA12379507  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA12379507  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IEA-  
GO:0005902microvillus-IEA-  
GO:0016020membrane-HDA19946888  
GO:0031143pseudopodium-IEA-  
GO:0035748myelin sheath abaxonal region-IEA-  
GO:0035749myelin sheath adaxonal region-IEA-  
GO:0042470melanosome-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18357522Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. (2009 Jan)Kristiansen LVNeurochem Res
23049750Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. (2012)Kumasaka NPLoS One
23747354Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. (2013 Sep 10)Manzardo AMGene
20399429Amino-terminal pro-C-type natriuretic peptide is associated with arterial stiffness, endothelial function and early atherosclerosis. (2010 Aug)Vlachopoulos CAtherosclerosis
18991845Injection of the neuropeptide CNP into dopaminergic rat brain areas decreases alcohol intake. (2008 Oct)Romieu PAnn N Y Acad Sci
17597189Resolution of cranial nerve paresis after endovascular management of cerebral aneurysms. (2007 Nov)Mansour NSurg Neurol