Gene: CNR1

1268
CANN6|CB-R|CB1|CB1A|CB1K5|CB1R|CNR
cannabinoid receptor 1
protein-coding
6q15
Ensembl:ENSG00000118432 MIM:114610 Vega:OTTHUMG00000015184 UniprotKB:P21554
NC_000006.12
PubMed
CD|OD|ND|AD
21   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.274e-3 (AD)  5.268e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VSTM2A0.929
RIMBP20.914
LRRTM40.914
ZNF804A0.91
GRIA40.907
IGSF30.907
MYT1L0.903
SHISA90.902
KCND20.901
GLRA30.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.551
MYL3-0.522
RNF135-0.515
REST-0.513
HEY2-0.511
TGFB3-0.499
ROM1-0.498
CMTM3-0.497
CHST14-0.495
MAGEA12-0.495

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00470DronabinolSmall Molecule1972-08-3Approved|IllicitTarget
DB00486NabiloneSmall Molecule51022-71-0Approved|InvestigationalTarget
DB02955Ricinoleic AcidSmall Molecule141-22-0ExperimentalTarget
DB05077SLV319Small Molecule-InvestigationalTarget
DB05201V24343Small Molecule-InvestigationalTarget
DB05372CP-945598Small Molecule-InvestigationalTarget
DB05750AVE-1625Small Molecule-InvestigationalTarget
DB06155RimonabantSmall Molecule168273-06-1Approved|InvestigationalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
DB09288PropacetamolSmall Molecule66532-85-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5705311,3-dihydroxypropan-2-yl 11-(2-hexyl-5-hydroxyphenoxy)undecanoate"1,3-dihydroxypropan-2-yl 11-(2-hexyl-5-hydroxyphenoxy)undecanoate binds to CNR1 protein"22044209
C5705321,3-dihydroxypropan-2-yl 11-(3-hydroxy-5-(2-methyloctan-2-yl)phenoxy)undecanoate"1,3-dihydroxypropan-2-yl 11-(3-hydroxy-5-(2-methyloctan-2-yl)phenoxy)undecanoate binds to CNR1 protein"22044209
C5823371-(5-fluoropentyl)-3-(1-naphthoyl)indole[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole24211273
C5823371-(5-fluoropentyl)-3-(1-naphthoyl)indoleCNR1 protein affects the susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole24211273
C5239831-(7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo(1,5-a)-(1,3,5)triazin-4-yl)-3-ethylaminoazetidine-3-carboxylic acid amide"1-(7-(2-chlorophenyl)-8-(4-chlorophenyl)-2-methylpyrazolo(1,5-a)-(1,3,5)triazin-4-yl)-3-ethylaminoazetidine-3-carboxylic acid amide binds to and results in decreased activity of CNR1 protein"17630359
C586710(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone"(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone binds to and results in increased activity of CNR1 protein"28496039
C586710(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone"(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone metabolite binds to and results in increased activity of CNR1 protein"28496039
C5525971-pentyl-3-(1-naphthoyl)indole[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-pentyl-3-(1-naphthoyl)indole24211273
C5525971-pentyl-3-(1-naphthoyl)indoleCNR1 protein affects the susceptibility to 1-pentyl-3-(1-naphthoyl)indole24211273
C5525971-pentyl-3-(1-naphthoyl)indole1-pentyl-3-(1-naphthoyl)indole binds to and results in increased activity of CNR1 protein23494106
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CNR1 mRNA"27291303
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]10871313
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of CNR1 mRNA"19114083
C0010732,4-dinitrobenzenesulfonic acid"CNR1 results in decreased susceptibility to 2,4-dinitrobenzenesulfonic acid"15085199
C5055592-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone binds to and results in increased activity of CNR1 protein16438957
C4981483-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl-4,4,4-trifluoro-1-butanesulfonate"3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl-4,4,4-trifluoro-1-butanesulfonate analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"21880487
C4981483-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl-4,4,4-trifluoro-1-butanesulfonate"3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl-4,4,4-trifluoro-1-butanesulfonate inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"21880487
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein"16438957
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP"10422789|1173071
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of CNR1 protein"19255745
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of CNR1 protein] which results in decreased secretion of CXCL8 protein"19255745
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of MAPK1 protein]"8526880
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased activity of MAPK3 protein]"8526880
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 binds to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"8526880
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP]"10422789
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein"18582849
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"AM 251 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]"18582849
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"LY 320135 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]"18582849
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of CNR1 protein"15107186
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of CNR1 protein"27513693
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in decreased activity of CNR1 protein"16148442
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein"12560108|1853674
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]"11891798
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which affects the expression of FOS protein"15280883
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased expression of FOS protein"12560108
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein"16113085|2060063
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"21907772|2421127
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of TH mRNA]"17540007
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 protein affects the susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"24211273
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNRIP1 protein inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of CNR1 protein]"27513693
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"Dronabinol inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"20600638
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]"18536748
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]"11891798
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl-4,4,4-trifluoro-1-butanesulfonate analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"21880487
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-cyano-3-(trifluoromethyl)phenoxy)phenyl-4,4,4-trifluoro-1-butanesulfonate inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"21880487
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the expression of CNR1 mRNA"10461028
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein"17953657
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]"12421626
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]"11727767
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]"14973253
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP"17953657
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased phosphorylation of PPP1R1B protein"17953657
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein"17397826|2188048
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of CNR1 mRNA"23151877
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased abundance of Nitric Oxide]"10027878
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"dibenzofuran analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"21880487
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"17397826
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]]"14973253
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]"11727767
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]"10027878
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein"17220914|1923716
C0153923-nitropropionic acid3-nitropropionic acid affects the expression of CNR1 mRNA15640759
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNR1 mRNA"27188386
C5823384-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone24211273
C5823384-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanoneCNR1 protein affects the susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone24211273
C5823384-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone binds to and results in increased activity of CNR1 protein23494106
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNR1 mRNA"27188386
D000079AcetaldehydeAcetaldehyde results in increased expression of CNR1 mRNA21863215
D000079AcetaldehydeAcetaldehyde promotes the reaction [Dronabinol results in increased expression of CNR1 mRNA]21863215
D000079AcetaldehydeAcetaldehyde promotes the reaction [glyceryl 2-arachidonate results in increased expression of CNR1 mRNA]21863215
D000082AcetaminophenAcetaminophen results in increased expression of CNR1 mRNA24448467|2512876
D000082Acetaminophensodium arsenite inhibits the reaction [Acetaminophen results in increased expression of CNR1 mRNA]24448467|2512876
D020106AcrylamideAcrylamide results in decreased expression of CNR1 mRNA28959563
D000242Cyclic AMP"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP"10422789|1173071
D000242Cyclic AMP"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP]"10422789
D000242Cyclic AMP"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP"17953657
D000242Cyclic AMP[Dronabinol binds to CNR1 protein] which results in decreased abundance of Cyclic AMP22851303
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CNR1 gene27153756
C103505AM 251AM 251 binds to and results in decreased activity of CNR1 protein18582849
C103505AM 251"AM 251 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]"18582849
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole24211273
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-pentyl-3-(1-naphthoyl)indole24211273
C103505AM 251"[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"21907772|2421127
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone24211273
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 4749721907772|2421127
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497 analog21907772|2421127
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to HU 21124211273
C103505AM 251AM 251 results in decreased activity of CNR1 protein17596442
C103505AM 251AM 251 binds to and results in decreased activity of CNR1 protein12509806
C103505AM 251[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide20590570
C103505AM 251AM 251 binds to and results in decreased activity of CNR1 protein16100529|1650064
C103505AM 251AM 251 results in decreased activity of CNR1 protein20626112
C109925AM 281AM 281 binds to and results in decreased activity of CNR1 protein17678736|1857219
C568441AM 694AM 694 binds to and results in increased activity of CNR1 protein23494106
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNR1 mRNA16483693
D003913DextroamphetamineCNR1 mutant form inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK1 protein]17596442
D003913DextroamphetamineCNR1 mutant form inhibits the reaction [Dextroamphetamine results in increased phosphorylation of MAPK3 protein]17596442
D003913DextroamphetamineCNR1 mutant form results in decreased susceptibility to Dextroamphetamine17596442
D000662AmphetaminesCNR1 polymorphism affects the susceptibility to Amphetamines9106242
C078814anandamide2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased activity of CNR1]10871313
C078814anandamideanandamide affects the activity of CNR1 protein19147270
C078814anandamideanandamide results in increased activity of CNR110871313
C078814anandamideCNR1 affects the reaction [TRPV1 affects the susceptibility to anandamide]15453094
C078814anandamidePertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]10871313
C078814anandamiderimonabant inhibits the reaction [anandamide results in increased activity of CNR1]10871313
C078814anandamide[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]11891798
C078814anandamideCNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]12657697
C078814anandamideCNR1 gene mutant form inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]12657697
C078814anandamiderimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
C078814anandamideSR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
C078814anandamideanandamide binds to and results in increased activity of CNR1 protein17459108
C078814anandamideanandamide binds to CNR1 protein11408034
C078814anandamideanandamide results in increased activity of CNR1 protein14504685|1755791
C078814anandamideanandamide binds to and results in increased activity of CNR1 protein19002671|1923716
C078814anandamideanandamide binds to CNR1 protein18599552|1940379
C119325arachidonyl-2-chloroethylamideCNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]12734338
C119325arachidonyl-2-chloroethylamideCNR1 protein affects the reaction [arachidonyl-2-chloroethylamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]12734338
C119325arachidonyl-2-chloroethylamidearachidonyl-2-chloroethylamide binds to and results in increased activity of CNR1 protein18234885
C474941arachidonyl dopaminearachidonyl dopamine binds to and results in increased activity of CNR1 protein17459108
C474941arachidonyl dopaminearachidonyl dopamine binds to and results in increased activity of CNR1 protein12569099
D000068180AripiprazoleAripiprazole results in increased expression of CNR1 mRNA17868501
C121153arvanilarvanil binds to CNR1 protein11861807
C121153arvanilarvanil binds to and results in increased activity of CNR1 protein17459108
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of CNR1 mRNA"23917077
C416282BAY 11-7085BAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
C005177benserazide, levodopa drug combination"CNR1 affects the susceptibility to benserazide, levodopa drug combination"19419794
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CNR1 mRNA17404688
D001647Bile Acids and SaltsCNR1 gene mutant form inhibits the reaction [Ethanol results in increased abundance of Bile Acids and Salts]23894352
C006780bisphenol Abisphenol A results in increased expression of CNR1 mRNA27014939
C006780bisphenol Abisphenol A results in decreased expression of CNR1 mRNA27641926
C006780bisphenol Abisphenol A results in decreased expression of CNR1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CNR1 mRNA28628672
D001761BleomycinBleomycin results in decreased expression of CNR1 mRNA15808516
D001960BromazepamCNR1 results in increased susceptibility to Bromazepam15081793
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CNR1 mRNA22079614
D002065BuspironeCNR1 affects the susceptibility to Buspirone15081793
C006863butyl phosphorotrithioatebutyl phosphorotrithioate inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C006863butyl phosphorotrithioatebutyl phosphorotrithioate results in decreased activity of CNR1 protein12243867
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CNR1 promoter22457795
D002118Calcium"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]"12421626
D002118Calcium"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]"14973253
D002118CalciumCalcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 mRNA]16412482
D002118CalciumCalcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 protein]16412482
D002118Calcium"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
D002118CalciumCNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
D002118Calcium"Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]]"14973253
D002118Calcium"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
D002118Calciumrimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
D002118Calcium[Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]12421626
D002185CannabidiolCNR1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]20668920
D002211CapsaicinCNR1 protein affects the reaction [Capsaicin results in increased secretion of CALCA protein]18987195
D002211CapsaicinCNR1 protein affects the susceptibility to Capsaicin18987195
D002211CapsaicinCapsaicin results in increased activity of CNR1 protein11408034
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of CNR1 mRNA18636392
D002737ChloropreneChloroprene results in decreased expression of CNR1 mRNA23125180
C007031chlorpyrifos-methylchlorpyrifos-methyl inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C007031chlorpyrifos-methylchlorpyrifos-methyl results in decreased activity of CNR1 protein12243867
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CNR1 gene20938992
D015283CitalopramCitalopram results in decreased expression of CNR1 protein28866072
D003042CocaineCNR1 gene polymorphism affects the susceptibility to Cocaine16314880
D003042CocaineCNR1 gene SNP affects the susceptibility to Cocaine19052543
D003042CocaineCNR1 polymorphism affects the susceptibility to Cocaine9106242
D003042CocaineCNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]17596442
D003042CocaineCNR1 mutant form inhibits the reaction [Cocaine results in increased expression of FOS protein]17596442
D003042CocaineCNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]17596442
D003042CocaineCNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]17596442
D003042CocaineCNR1 mutant form results in decreased susceptibility to Cocaine17596442
D003042CocaineCocaine results in increased activity of CNR1 protein20554863
D003345CorticosteroneCNR1 gene mutant form results in increased abundance of Corticosterone15081793
C036088CP 47497[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 4749721907772|2421127
C036088CP 47497[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497 analog21907772|2421127
C036088CP 47497CNR1 protein affects the susceptibility to CP 4749724211273
C036088CP 47497CNR1 protein affects the susceptibility to CP 47497 analog24211273
C065365CP 55244butyl phosphorotrithioate inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C065365CP 55244chlorpyrifos-methyl inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C065365CP 55244CP 55244 binds to CNR1 protein12243867
C065365CP 55244diazoxon inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C065365CP 55244Dichlorvos inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C065365CP 55244"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [CP 55244 binds to CNR1 protein]"12243867
C065365CP 55244Paraoxon inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C529311CTAP octapeptideCTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]22258905
D003471CuprizoneCuprizone results in decreased expression of CNR1 mRNA26577399
D003513CycloheximideCycloheximide inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D003513CycloheximideCycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]22258905
D003513CycloheximideCycloheximide results in decreased expression of and affects the localization of CNR1 protein27513693
D003561CytarabineCytarabine results in increased expression of CNR1 mRNA21198554
D003609DactinomycinDactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CNR1 mRNA23640034
C014347decitabinedecitabine results in increased expression of CNR1 mRNA22262103
D013759DronabinolCNR1 affects the reaction [Dronabinol results in increased activity of MAPK1 protein]8526880
D013759DronabinolCNR1 affects the reaction [Dronabinol results in increased activity of MAPK3 protein]8526880
D013759DronabinolCNR1 polymorphism affects the susceptibility to Dronabinol21513772
D013759DronabinolCycloheximide inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759DronabinolDronabinol results in increased expression of CNR1 mRNA17041005
D013759DronabinolIL4 protein mutant form inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759Dronabinoliodopravadoline inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759DronabinolSTAT5A affects the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759DronabinolSTAT6 affects the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D013759DronabinolCNR1 affects the susceptibility to Dronabinol17927447
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of and results in decreased phosphorylation of CREB1 protein]19912468
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of GRIA1]19912468
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of GRIN2A]19912468
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of GRIN2B]19912468
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of IFNG protein]18792785
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in decreased expression of IL12RB2 mRNA]18792785
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]12657697
D013759DronabinolCNR1 gene mutant form inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]12657697
D013759DronabinolCNR1 protein affects the susceptibility to Dronabinol10318961
D013759DronabinolCNR1 results in increased susceptibility to Dronabinol19912468
D013759DronabinolDronabinol affects the expression of CNR1 mRNA16760363
D013759Dronabinol"Dronabinol inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"20600638
D013759DronabinolDronabinol results in decreased expression of CNR1 mRNA21955143
D013759DronabinolDronabinol results in decreased expression of CNR1 protein16760363
D013759DronabinolDronabinol results in increased expression of CNR117289082
D013759DronabinolAcetaldehyde promotes the reaction [Dronabinol results in increased expression of CNR1 mRNA]21863215
D013759DronabinolDronabinol affects the expression of CNR1 mRNA10461028|9813289
D013759DronabinolDronabinol results in decreased expression of CNR1 mRNA10733937
D013759DronabinolDronabinol results in increased activity of CNR1 protein11517236
D013759DronabinolDronabinol results in increased expression of CNR1 mRNA21863215
D013759Dronabinol[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol9351646
D013759Dronabinolrimonabant inhibits the reaction [Dronabinol results in increased activity of CNR1 protein]11517236
D013759DronabinolCNR1 affects the reaction [Dronabinol results in decreased sumoylation of TP53 protein]19819240
D013759DronabinolDronabinol binds to and results in increased activity of CNR1 protein23494106
D013759DronabinolDronabinol binds to CNR1 protein22851303
D013759Dronabinol[Dronabinol binds to CNR1 protein] which results in decreased abundance of Cyclic AMP22851303
D013759DronabinolDronabinol results in decreased activity of CNR1 protein10101241
D013759DronabinolDronabinol results in decreased expression of CNR1 mRNA10101241
D013759DronabinolDronabinol results in decreased sumoylation of CNR1 protein19819240
D003907DexamethasoneDexamethasone results in increased expression of CNR1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CNR1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CNR1 mRNA28628672
D016264Dextran SulfateCNR1 results in decreased susceptibility to Dextran Sulfate15085199
D003975DiazepamCNR1 protein affects the susceptibility to Diazepam17442049
C000912diazoxondiazoxon inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
C000912diazoxondiazoxon results in decreased activity of CNR1 protein12243867
C023614dibenzofuran"dibenzofuran analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"21880487
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CNR1 mRNA15620428
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CNR1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CNR1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CNR1 mRNA27392435
D004006DichlorvosDichlorvos inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
D004006DichlorvosDichlorvos results in decreased activity of CNR1 protein12243867
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of CNR1 mRNA20110567
D004041Dietary FatsDietary Fats results in increased expression of CNR1 mRNA20110567
D004041Dietary FatsDietary Fats results in decreased expression of CNR1 mRNA18721800
D019422Dietary SucroseDietary Sucrose results in increased expression of CNR1 mRNA18627777
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of CNR1 mRNA15620428
D016291Dizocilpine MaleateCNR1 protein affects the susceptibility to Dizocilpine Maleate17442049
D004317DoxorubicinCNR1 protein affects the susceptibility to Doxorubicin19942623
C118739entinostatentinostat results in decreased expression of CNR1 mRNA27188386
D004837Epinephrinerimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine]11704653
D004837Epinephrine[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine11704653
D000431EthanolCNR1 gene mutant form affects the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of NOS2 mRNA]21863215
D000431EthanolCNR1 gene mutant form affects the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TNF mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of ACTA2 mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of COL1A1 mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP2 mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TGFB1 mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TIMP1 mRNA]21863215
D000431EthanolCNR1 gene mutant form inhibits the reaction [Ethanol results in increased abundance of Bile Acids and Salts]23894352
D000431EthanolCNR1 protein affects the susceptibility to Ethanol17442049|2389435
D000431EthanolCNR1 results in increased susceptibility to [Ethanol co-treated with Thioacetamide]21863215
D000431EthanolEthanol results in decreased expression of CNR1 mRNA21955143
D000431EthanolEthanol affects the expression of CNR1 mRNA11772933
D000431EthanolEthanol results in decreased expression of CNR1 mRNA18713641
D005473FluoxetineFluoxetine results in decreased expression of and results in decreased phosphorylation of CNR1 protein18722357
D005473FluoxetineFluoxetine results in decreased expression of CNR1 mRNA15936043
D005492Folic AcidFolic Acid results in increased expression of CNR1 mRNA25006883
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CNR1 gene20938992
D005632FructoseFructose results in increased expression of CNR1 mRNA18627777
C039281furanfuran results in increased methylation of CNR1 gene22079235
C056507gemcitabineBAY 11-7085 inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
C056507gemcitabinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
C056507gemcitabineDactinomycin inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
C056507gemcitabinegemcitabine results in increased expression of CNR1 mRNA21525939
C056507gemcitabinepyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
D005947GlucoseGlucose results in decreased expression of CNR1 mRNA19501110
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP27A1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7B1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP8B1 mRNA]23894352
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK1 protein]12657697
C094503glyceryl 2-arachidonateCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased phosphorylation of and results in increased activity of MAPK3 protein]12657697
C094503glyceryl 2-arachidonateCNR1 protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]26209559
C094503glyceryl 2-arachidonateAcetaldehyde promotes the reaction [glyceryl 2-arachidonate results in increased expression of CNR1 mRNA]21863215
C094503glyceryl 2-arachidonateglyceryl 2-arachidonate results in increased expression of CNR1 mRNA15899896|2186321
C094503glyceryl 2-arachidonateNitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]16775503
C062018HU 211CNR1 results in increased susceptibility to HU 21119509271
C062018HU 211HU 211 binds to and results in increased activity of CNR1 protein16438957
C062018HU 211HU 211 results in increased activity of CNR110871313
C062018HU 211Pertussis Toxin inhibits the reaction [HU 211 results in increased activity of CNR1]10871313
C062018HU 211rimonabant inhibits the reaction [HU 211 results in increased activity of CNR1]10871313
C062018HU 211[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to HU 21124211273
C062018HU 211CNR1 mutant form inhibits the reaction [HU 211 results in increased phosphorylation of PTK2 protein]12163181
C062018HU 211CNR1 protein affects the reaction [HU 211 results in decreased expression of TH mRNA]17540007
C062018HU 211CNR1 protein affects the susceptibility to HU 21124211273
C062018HU 211HU 211 binds to and results in increased activity of CNR1 protein18536748
C062018HU 211rimonabant inhibits the reaction [HU 211 binds to and results in increased activity of CNR1 protein]18536748
C062018HU 211HU 211 binds to and results in increased activity of CNR1 protein11558437
C062018HU 211HU 211 results in decreased expression of CNR1 mRNA12968131
C062018HU 211HU 211 binds to and results in increased activity of CNR1 protein10570211|1508519
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CNR1 mRNA21863215
C569626ibipinabantibipinabant binds to and results in decreased activity of CNR1 protein22821849
D007052Ibuprofen"Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein]"17397826
D007099ImipramineImipramine results in decreased expression of CNR1 protein28866072
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CNR1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CNR1 mRNA28628672
C094023iodopravadolineiodopravadoline inhibits the reaction [Dronabinol results in increased expression of CNR1 mRNA]17041005
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CNR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CNR1 mRNA28628672
C402944JHW 015JHW 015 results in increased expression of CNR1 mRNA17041005
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CNR1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CNR1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of CNR1 mRNA15618438
C568258JWH-073JWH-073 binds to and results in increased activity of CNR1 protein23494106
C534333JZL 184CNR1 protein affects the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased cleavage of and results in increased activity of CASP3 protein]]26209559
C534333JZL 184CNR1 protein affects the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]26209559
C534333JZL 184CNR1 protein affects the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]26209559
D007608Kainic AcidKainic Acid results in increased expression of CNR1 mRNA22079489
D007649KetamineKetamine results in decreased expression of CNR1 mRNA20080153
D008070Lipopolysaccharides"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]"11891798
D008070Lipopolysaccharides[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]11891798
D008070Lipopolysaccharides"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]"11891798
D008070Lipopolysaccharidesrimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
D008070LipopolysaccharidesSR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
D008070Lipopolysaccharides"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]"11727767
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CNR1 mRNA24448467
D008070Lipopolysaccharides"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]"11727767
C110158LY 320135LY 320135 binds to and results in decreased activity of CNR1 protein18582849
C110158LY 320135"LY 320135 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]"18582849
D008466MechlorethamineMechlorethamine results in increased expression of CNR1 protein27125198
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of CNR1 mRNA20843944
D008694MethamphetamineCNR1 protein affects the susceptibility to Methamphetamine17953657
C088155methanandamidemethanandamide binds to and results in increased activity of CNR1 protein21109016
C088155methanandamide[methanandamide binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Progesterone21109016
C088155methanandamide[methanandamide binds to and results in increased activity of CNR1 protein] which results in decreased expression of LHCGR mRNA21109016
C088155methanandamide[methanandamide binds to and results in increased activity of CNR1 protein] which results in decreased expression of LHCGR protein21109016
C088155methanandamideCNR1 protein affects the reaction [methanandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]12734338
C088155methanandamideCNR1 protein affects the reaction [methanandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]12734338
C088155methanandamidemethanandamide binds to and results in increased activity of CNR1 protein18247126
C088155methanandamidemethanandamide binds to CNR1 protein17041005
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CNR1 gene20938992
D008727MethotrexateMethotrexate affects the expression of CNR1 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CNR1 mRNA"20188158
D008774MethylphenidateMethylphenidate results in increased expression of CNR1 mRNA22470460
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of CNR1 mRNA24128854
D009020MorphineCTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]22258905
D009020MorphineCycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]22258905
D009020MorphineMorphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]22258905
D009020MorphineMorphine results in increased expression of CNR1 mRNA21955143
D009020MorphineMorphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]22258905
D009020MorphineMorphine results in increased expression of CNR1 mRNA9351646
D009020Morphine[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol9351646
C523799MRK 003MRK 003 results in decreased expression of CNR1 mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of CNR1 protein27125198
C521311N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamideN-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide binds to and results in decreased activity of CNR1 protein17327489
C521311N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamideN-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide binds to CNR1 protein17327489
C521311N-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamideN-(3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)propanamide binds to and results in decreased activity of CNR1 protein19046740
C107594N-(4-hydroxyphenyl)arachidonylamide[N-(4-hydroxyphenyl)arachidonylamide binds to and results in increased activity of CNR1 protein] which affects the expression of FOS protein15280883
C028473N-acetyl-4-benzoquinoneimineCNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D009538NicotineCNR1 protein affects the susceptibility to Nicotine12384171
D009538NicotineNicotine results in increased expression of CNR1 mRNA21955143
D009538Nicotine[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine16416159
C012655nimesulide[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide20590570
D009569Nitric Oxide"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]"11891798
D009569Nitric Oxide[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]11891798
D009569Nitric Oxide"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]"11891798
D009569Nitric Oxiderimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
D009569Nitric OxideSR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
D009569Nitric Oxide"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]"11727767
D009569Nitric Oxide"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased abundance of Nitric Oxide]"10027878
D009569Nitric Oxide"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]"11727767
D009569Nitric Oxide"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]"10027878
D005996NitroglycerinNitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]16775503
C424442noladin ethernoladin ether binds to CNR1 protein22044209
C488796N-oleoyldopamineN-oleoyldopamine binds to and results in increased activity of CNR1 protein12569099
C025256nonylphenolnonylphenol results in decreased expression of CNR1 mRNA15620428
D016627OxidopamineCNR1 affects the susceptibility to Oxidopamine19419794
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate inhibits the reaction [CP 55244 binds to CNR1 protein]"12243867
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased activity of CNR1 protein"12243867
D010100OxygenOxygen deficiency results in decreased expression of CNR1 mRNA21863215
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of CNR1 mRNA18636392
C005958palmidrol[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog17558434
D010261ParaoxonParaoxon inhibits the reaction [CP 55244 binds to CNR1 protein]12243867
D010261ParaoxonParaoxon results in decreased activity of CNR1 protein12243867
C409945parecoxibCNR1 protein results in increased susceptibility to parecoxib23371449
D010424PentobarbitalCNR1 protein affects the susceptibility to Pentobarbital17442049
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [anandamide results in increased activity of CNR1]10871313
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [CNR1 results in increased activity of MAPK1 protein]8526880
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [CNR1 results in increased activity of MAPK3 protein]8526880
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [HU 211 results in increased activity of CNR1]10871313
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [Win 55212-2 results in increased activity of CNR1]10871313
D037342Pertussis Toxin"Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]]"14973253
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNR1 mRNA"27188386
D010862PilocarpinePilocarpine results in decreased expression of CNR1 protein19368833
D010880PiperidinesPiperidines analog binds to and results in decreased activity of CNR1 protein16279795
D011188Potassium"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]"14973253
D011188Potassium"Pertussis Toxin inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium results in increased transport of Calcium]]"14973253
D011189Potassium Chloride"[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]"12421626
D011189Potassium ChlorideCalcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 mRNA]16412482
D011189Potassium ChlorideCalcium affects the reaction [Potassium Chloride results in decreased expression of CNR1 protein]16412482
D011189Potassium Chloride"CNR1 protein affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
D011189Potassium ChlorideCNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
D011189Potassium ChloridePotassium Chloride results in decreased expression of CNR1 mRNA16412482
D011189Potassium ChloridePotassium Chloride results in decreased expression of CNR1 protein16412482
D011189Potassium Chloride"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
D011189Potassium Chloriderimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
D011189Potassium Chloride[Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]12421626
D000069583PregabalinPregabalin affects the expression of CNR1 mRNA22017514
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CNR1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of CNR1 mRNA17404688|2086464
D011374Progesterone[methanandamide binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Progesterone21109016
D011441PropylthiouracilPropylthiouracil results in increased expression of CNR1 mRNA24780913
D011720PyrazolesPyrazoles analog binds to and results in decreased activity of CNR1 protein16279795
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [gemcitabine results in increased expression of CNR1 mRNA]21525939
D012110ReserpineReserpine results in decreased expression of CNR1 mRNA11358453
C030521ricinoleic acidricinoleic acid analog binds to CNR1 protein16406364
C089032rimonabantrimonabant binds to and results in decreased activity of CNR1 protein17592669
C089032rimonabantrimonabant affects the localization of CNR1 protein16822929
C089032rimonabantrimonabant binds to and results in decreased activity of CNR1 protein11730719|2010743
C089032rimonabantrimonabant binds to CNR1 protein21702498
C089032rimonabant"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in increased abundance of Cyclic AMP]"10422789
C089032rimonabantrimonabant inhibits the reaction [anandamide results in increased activity of CNR1]10871313
C089032rimonabantrimonabant inhibits the reaction [HU 211 results in increased activity of CNR1]10871313
C089032rimonabantrimonabant inhibits the reaction [Win 55212-2 results in increased activity of CNR1]10871313
C089032rimonabantrimonabant affects the localization of CNR1 protein27513693
C089032rimonabantrimonabant binds to and results in decreased activity of CNR1 protein12560108|1614844
C089032rimonabant[rimonabant binds to and results in decreased activity of CNR1 protein] which affects the expression of FOS protein15280883
C089032rimonabant[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Nicotine16416159
C089032rimonabantrimonabant binds to CNR1 protein16113085
C089032rimonabant"rimonabant inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein]"18536748
C089032rimonabant"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]"11891798
C089032rimonabantrimonabant inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
C089032rimonabantrimonabant inhibits the reaction [HU 211 binds to and results in increased activity of CNR1 protein]18536748
C089032rimonabantrimonabant results in decreased expression of CNR1 mRNA20110567
C089032rimonabantrimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine]11704653
C089032rimonabantrimonabant binds to and results in decreased activity of CNR1 protein11558437|1250980
C089032rimonabant[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to palmidrol analog17558434
C089032rimonabant[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Win 55212-217572696
C089032rimonabant"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [IFNG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]]"11727767
C089032rimonabant"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]"12421626
C089032rimonabant"rimonabant inhibits the reaction [[3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Nitric Oxide]"10027878
C089032rimonabantrimonabant inhibits the reaction [Dronabinol results in increased activity of CNR1 protein]11517236
C089032rimonabantrimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
C089032rimonabantrimonabant binds to and affects the activity of CNR1 protein17220538
C089032rimonabantrimonabant binds to and results in decreased activity of CNR1 protein10570211|1070055
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CNR1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CNR1 mRNA22300531
D012834SilverSilver results in decreased expression of CNR1 mRNA26551752
D012834SilverSilver results in decreased expression of CNR1 mRNA27131904
C017947sodium arsenitesodium arsenite inhibits the reaction [Acetaminophen results in increased expression of CNR1 mRNA]24448467|2512876
C017947sodium arsenitesodium arsenite results in decreased expression of CNR1 mRNA24448467|2512876
C110630SR 144528SR 144528 inhibits the reaction [[anandamide binds to and results in increased activity of CNR1 protein] inhibits the reaction [Lipopolysaccharides results in increased transport of Nitric Oxide]]11891798
D013458Sulfur DioxideCNR1 protein affects the reaction [glyceryl 2-arachidonate inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]26209559
D013458Sulfur DioxideCNR1 protein affects the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased cleavage of and results in increased activity of CASP3 protein]]26209559
D013458Sulfur DioxideCNR1 protein affects the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased expression of PTGS2 protein]]26209559
D013458Sulfur DioxideCNR1 protein affects the reaction [JZL 184 inhibits the reaction [Sulfur Dioxide results in increased phosphorylation of RELA protein]]26209559
D013549Sweetening AgentsSweetening Agents results in increased expression of CNR1 mRNA18627777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNR1 mRNA21570461
D013853ThioacetamideCNR1 gene mutant form affects the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of NOS2 mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form affects the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TNF mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of ACTA2 mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of COL1A1 mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP2 mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TGFB1 mRNA]21863215
D013853ThioacetamideCNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TIMP1 mRNA]21863215
D013853ThioacetamideCNR1 results in increased susceptibility to [Ethanol co-treated with Thioacetamide]21863215
C052342topiramatetopiramate affects the expression of CNR1 mRNA22017514
D014118Toxins, Biological"Toxins, Biological affects the expression of CNR1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of CNR1 mRNA21934132|2372400
D014212TretinoinTretinoin results in increased expression of CNR1 mRNA16477621
D014212TretinoinTretinoin results in increased expression of CNR1 protein16477621
C012589trichostatin Atrichostatin A results in increased expression of CNR1 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of CNR1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of CNR1 mRNA24383497|2493525
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of CNR1 mRNA25423262
C456739virodhaminevirodhamine results in increased activity of CNR1 protein19255745
C456739virodhamine[virodhamine results in increased activity of CNR1 protein] which affects the secretion of CXCL8 protein19255745
C070417Win 55212-2CNR1 affects the reaction [Win 55212-2 results in increased activity of MAPK1 protein]8526880
C070417Win 55212-2CNR1 affects the reaction [Win 55212-2 results in increased activity of MAPK3 protein]8526880
C070417Win 55212-2Pertussis Toxin inhibits the reaction [Win 55212-2 results in increased activity of CNR1]10871313
C070417Win 55212-2rimonabant inhibits the reaction [Win 55212-2 results in increased activity of CNR1]10871313
C070417Win 55212-2Win 55212-2 binds to and results in increased activity of CNR1 protein16438957
C070417Win 55212-2Win 55212-2 binds to CNR1 protein22044209
C070417Win 55212-2Win 55212-2 results in increased activity of CNR110871313
C070417Win 55212-2CNRIP1 protein inhibits the reaction [Win 55212-2 affects the localization of CNR1 protein]27513693
C070417Win 55212-2Win 55212-2 affects the localization of CNR1 protein27513693
C070417Win 55212-2Win 55212-2 binds to and results in increased activity of CNR1 protein12560108
C070417Win 55212-2[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in increased expression of FOS protein12560108
C070417Win 55212-2rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine]11704653
C070417Win 55212-2[Win 55212-2 binds to and results in increased activity of CNR1 protein] which results in decreased abundance of Epinephrine11704653
C070417Win 55212-2CNR1 protein affects the reaction [Win 55212-2 inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
C070417Win 55212-2[rimonabant binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to Win 55212-217572696
C070417Win 55212-2rimonabant inhibits the reaction [[Win 55212-2 binds to and results in increased activity of CNR1 protein] inhibits the reaction [Potassium Chloride results in increased transport of Calcium]]12421626
C070417Win 55212-2Win 55212-2 binds to and results in increased activity of CNR1 protein17572696|2128169
C070417Win 55212-2[Win 55212-2 binds to and results in increased activity of CNR1 protein] affects the reaction [Potassium Chloride results in increased transport of Calcium]12421626
C070417Win 55212-2Win 55212-2 binds to and results in increased activity of CNR1 protein12539206|1722091

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004949cannabinoid receptor activity-IDA18761332  
GO:0005515protein binding-IPI17895407  26158621  
GO:0008144drug binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002866positive regulation of acute inflammatory response to antigenic stimulus-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS1718258  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IDA18761332  
GO:0007283spermatogenesis-IEA-  
GO:0007413axonal fasciculation-IEA-  
GO:0007568aging-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0007613memory-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0019233sensory perception of pain-IEA-  
GO:0031622positive regulation of fever generation-IEA-  
GO:0031999negative regulation of fatty acid beta-oxidation-IEA-  
GO:0032228regulation of synaptic transmission, GABAergic-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0033004negative regulation of mast cell activation-IEA-  
GO:0033602negative regulation of dopamine secretion-IEA-  
GO:0035094response to nicotine-IEA-  
GO:0038171cannabinoid signaling pathway-IDA17895407  
GO:0042220response to cocaine-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043278response to morphine-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0045759negative regulation of action potential-IEA-  
GO:0045776negative regulation of blood pressure-IEA-  
GO:0045777positive regulation of blood pressure-IEA-  
GO:0050796regulation of insulin secretion-IEA-  
GO:0051001negative regulation of nitric-oxide synthase activity-IEA-  
GO:0051966regulation of synaptic transmission, glutamatergic-IEA-  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0060259regulation of feeding behavior-IEA-  
GO:0060405regulation of penile erection-IEA-  
GO:0099553trans-synaptic signaling by endocannabinoid, modulating synaptic transmission-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005886plasma membrane-IDA17895407  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS1718258  
GO:0030426growth cone-IEA-  
GO:0042734presynaptic membrane-IEA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12657705A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. (2003 Mar 15)Racz IJ Neurosci
21790903Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis. (2013 Jul)Clarke TKAddict Biol
24060590Differential expression and functional role of cannabinoid genes in alcohol users. (2013 Dec 1)Agudelo MDrug Alcohol Depend
16741937Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. (2006 Jul 5)Herman AIAm J Med Genet B Neuropsychiatr Genet
17449448Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene. (2007 Jan)Hoenicka JNeurotox Res
14714115Alcoholism-related phenotypes and genetic variants of the CB1 receptor. (2003 Dec)Preuss UWEur Arch Psychiatry Clin Neurosci
21808284Gender-stratified gene and gene-treatment interactions in smoking cessation. (2012 Dec)Lee WPharmacogenomics J
11841893Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. (2002 Feb 1)Schmidt LGDrug Alcohol Depend
17509535CNR1 variation modulates risk for drug and alcohol dependence. (2007 Sep 15)Zuo LBiol Psychiatry
27453054Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal. (2016 Sep)Evans DEGenes Brain Behav
22085192Cannabinoid receptor 1 gene is associated with alcohol dependence. (2012 Feb)Marcos MAlcohol Clin Exp Res
19052543Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. (2009 May)Zuo LNeuropsychopharmacology
22776901Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. (2013 Aug)Hirvonen JMol Psychiatry
26331953A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients. (2015 Oct)Icick RAm J Addict
22334331Variability in CNR1 locus influences protein intake and smoking status in the Central-European population. (2012 Jul)Bienertova-Vasku JNutr Neurosci
18606954Cannabinoid receptor 1 gene association with nicotine dependence. (2008 Jul)Chen XArch Gen Psychiatry
18606956The incentive salience of alcohol: translating the effects of genetic variant in CNR1. (2008 Jul)Hutchison KEArch Gen Psychiatry
22046326'Smoking genes': a genetic association study. (2011)Verde ZPLoS One
18519829An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. (2008 Jun)Agrawal AArch Gen Psychiatry
16314880(AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. (2006 Mar-Apr)Ballon NPharmacogenomics J
11341859The cannabinoid receptor gene (CNR1) is not affected in German i.v. drug users. (2001 Apr)Heller DAddict Biol