Gene: IFFO2

126917
-
intermediate filament family orphan 2
protein-coding
1p36.13
Ensembl:ENSG00000169991 Vega:OTTHUMG00000002499 UniprotKB:Q5TF58
NC_000001.11
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.276e-1 (AD)  1.238e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4912013chr1:18958070 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg09012001chr1:19250279IFFO28.800e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHERP0.859
MORC20.857
ZNF7460.855
ATXN2L0.854
LRRC410.85
BAHD10.848
BRD40.848
PRPF80.846
NLGN20.844
CLUH0.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.573
OR4F29-0.526
KLRC2-0.323
CTNNA3-0.312
FGFBP2-0.309
SH2D1A-0.306
FMO3-0.293
ARHGEF35-0.292
CD48-0.283
IFNG-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of IFFO2 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFFO2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFFO2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of IFFO2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of IFFO2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IFFO2 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of IFFO2 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of IFFO2 mRNA28522335
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IFFO2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IFFO2 mRNA23735875
C006780bisphenol Abisphenol A results in decreased expression of IFFO2 mRNA28159858
C018475butyraldehydebutyraldehyde results in decreased expression of IFFO2 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of IFFO2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of IFFO2 mRNA25979313
D016572CyclosporineCyclosporine results in decreased expression of IFFO2 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of IFFO2 mRNA23640034
D003703DemecolcineDemecolcine results in increased expression of IFFO2 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IFFO2 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of IFFO2 mRNA28302478
D005557FormaldehydeFormaldehyde results in decreased expression of IFFO2 mRNA20655997
C492448ICG 001ICG 001 results in decreased expression of IFFO2 mRNA26191083
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IFFO2 mRNA28001369
C523799MRK 003IFFO2 results in increased susceptibility to MRK 00319903844
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of IFFO2 mRNA28174063
D009532NickelNickel results in increased expression of IFFO2 mRNA23195993
D010634PhenobarbitalPhenobarbital affects the expression of IFFO2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFFO2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IFFO2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IFFO2 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IFFO2 mRNA22714537
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IFFO2 mRNA]16891777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IFFO2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IFFO2 mRNA16891777|1977048
C012589trichostatin Atrichostatin A results in increased expression of IFFO2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of IFFO2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of IFFO2 mRNA29024780
D014520UrethaneUrethane results in increased expression of IFFO2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of IFFO2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of IFFO2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of IFFO2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IFFO2 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of IFFO2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005882intermediate filament-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal