Gene: SLC44A3

126969
CTL3
solute carrier family 44 member 3
protein-coding
1p21.3
Ensembl:ENSG00000143036 Vega:OTTHUMG00000010700 UniprotKB:Q8N4M1
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  6.472e-1 (ND)   (Frontal_Cortex)
6.645e-1 (AD)  9.053e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11165257chr1:94836579 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNN30.884
TMBIM10.878
TRAF3IP20.865
ABHD40.859
NEK60.855
LRP100.852
FGF20.849
MGST10.847
PALLD0.845
LGALS30.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.555
CALHM1-0.522
PPEF1-0.515
SLC7A4-0.514
LHX6-0.509
AGMAT-0.507
NEUROD6-0.507
ADTRP-0.498
ADRA1D-0.491
FBLN7-0.483

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00122CholineSmall Molecule62-49-7Approved|NutraceuticalTransporter
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SLC44A3 mRNA"28903501
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC44A3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC44A3 mRNA27153756
D001379AzathioprineAzathioprine results in decreased expression of SLC44A3 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of SLC44A3 mRNA22323515
C487081belinostatbelinostat results in decreased expression of SLC44A3 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC44A3 mRNA21632981
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SLC44A3 mRNA20660070
C006780bisphenol Abisphenol A results in increased expression of SLC44A3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC44A3 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC44A3 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC44A3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SLC44A3 mRNA20106945|2490755
C526360dechlorane plusdechlorane plus results in increased expression of SLC44A3 mRNA22913625
C000944dicrotophosdicrotophos results in decreased expression of SLC44A3 mRNA28302478
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SLC44A3 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of SLC44A3 mRNA]19850644
C118739entinostatentinostat results in increased expression of SLC44A3 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC44A3 gene20938992
C039281furanfuran results in increased expression of SLC44A3 mRNA25539665
C492448ICG 001ICG 001 results in increased expression of SLC44A3 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SLC44A3 mRNA24796395|2675264
D048628KetolidesKetolides analog results in increased expression of SLC44A3 mRNA24967691
C042720mercuric bromidemercuric bromide results in increased expression of SLC44A3 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SLC44A3 gene20938992
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of SLC44A3 mRNA29162477
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC44A3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC44A3 mRNA"25620056
C558013NSC 689534NSC 689534 results in increased expression of SLC44A3 mRNA20971185
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC44A3 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of SLC44A3 mRNA18301758|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC44A3 mRNA27413110|2890350
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SLC44A3 mRNA20660070
D011374ProgesteroneNCOA2 protein affects the reaction [Progesterone results in decreased expression of SLC44A3 mRNA]17556502
D011374ProgesteroneProgesterone results in decreased expression of SLC44A3 mRNA17556502
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC44A3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of SLC44A3 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC44A3 mRNA25895662
D053260SootSoot results in decreased expression of SLC44A3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC44A3 mRNA20106945|2163298
D013792ThalidomideThalidomide results in decreased expression of SLC44A3 mRNA26217789
D014212TretinoinTretinoin results in decreased expression of SLC44A3 mRNA23724009
D014212TretinoinTretinoin results in increased expression of SLC44A3 mRNA21934132
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC44A3 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC44A3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SLC44A3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC44A3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SLC44A3 mRNA17292431
D014640VancomycinVancomycin results in decreased expression of SLC44A3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC44A3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0015220choline transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006656phosphatidylcholine biosynthetic process-TAS-  
GO:0015871choline transport-IEA-  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483191Synthesis of PCTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal