Gene: CNTF

1270
HCNTF
ciliary neurotrophic factor
protein-coding
11q12.1
Ensembl:ENSG00000242689 MIM:118945 Vega:OTTHUMG00000137476 UniprotKB:P26441
NG_008776.1
PubMed
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.342e-1 (AD)  3.033e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LACC10.726
NEK70.71
SGMS20.71
VRK20.709
WIPF10.706
RAI140.705
RAB3IP0.702
ZEB20.696
SEPT100.692
CTNNA30.682

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYP46A1-0.535
CDH22-0.523
POU3F1-0.522
KCNQ4-0.515
SCRT1-0.511
LRRC73-0.502
HRH3-0.499
YBX2-0.498
DBNDD1-0.493
SPIRE2-0.492

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CNTF mRNA"21346803
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CNTF protein]26138014
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]16896058
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of CNTF mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of CNTF mRNA16483693|1744206
D000643Ammonium ChlorideAmmonium Chloride results in decreased expression of CNTF protein16483693|1744206
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]16896058
C006780bisphenol Abisphenol A results in decreased expression of CNTF mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of CNTF mRNA25181051
D002104CadmiumCadmium inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16843830
D002104CadmiumCadmium inhibits the reaction [CNTF protein affects the localization of STAT3 protein]16843830
D002104CadmiumCadmium inhibits the reaction [CNTF protein results in increased phosphorylation of MAPK1 protein]16843830
D002104CadmiumCadmium inhibits the reaction [CNTF protein results in increased phosphorylation of MAPK3 protein]16843830
D002104CadmiumCadmium inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16843830
D002104CadmiumCadmium inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16843830
D019256Cadmium Chloride"2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]"19635391
D019256Cadmium Chloride"2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]"19635391
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of CNTF protein]26138014
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein affects the localization of STAT3 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of MAPK1 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of MAPK3 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16843830
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]19635391
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of CNTF protein19635391
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CNTF protein26138014
D019256Cadmium ChlorideThioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D019256Cadmium ChlorideThioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]19635391
D019256Cadmium ChlorideThioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]19635391
D002211CapsaicinCapsaicin results in increased expression of CNTF protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D019327Copper SulfateCopper Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16896058
D019327Copper SulfateCopper Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16896058
D013759DronabinolDronabinol results in increased expression of CNTF mRNA16597638
D002945CisplatinFolic Acid affects the reaction [Cisplatin affects the expression of CNTF mRNA]16898872
D002945CisplatinCisplatin results in increased expression of CNTF mRNA19833167
D002945CisplatinIL6 gene mutant form promotes the reaction [Cisplatin results in increased expression of CNTF mRNA]19833167
D004041Dietary FatsDietary Fats results in increased expression of CNTF mRNA18042831
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of CNTF mRNA24834073
D005419FlavonoidsFlavonoids results in increased expression of CNTF mRNA18035473
D005492Folic AcidFolic Acid affects the reaction [Cisplatin affects the expression of CNTF mRNA]16898872
C039281furanfuran results in decreased expression of CNTF mRNA25539665
D005978GlutathioneGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D005978GlutathioneGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]16896058
C004312glycidolglycidol results in decreased expression of CNTF mRNA24915197
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]11882386
D0193071-(5-Isoquinolinesulfonyl)-2-Methylpiperazine1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]11882386
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16843830
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein affects the localization of STAT3 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]19635391
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased activity of CNTF protein15748169
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]15748169
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CNTF protein18090921
D008627Mercuric ChlorideAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideAcetylcysteine inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]16896058
D008627Mercuric ChlorideAscorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideAscorbic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]16896058
D008627Mercuric ChlorideGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]16896058
D008627Mercuric ChlorideGlutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]16896058
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16896058
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16896058
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D008627Mercuric ChlorideMercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]19635391
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of CNTF protein19635391
D008627Mercuric ChlorideThioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008627Mercuric ChlorideThioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]19635391
D008627Mercuric ChlorideThioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]19635391
D008767Methylmercury CompoundsMethylmercury Compounds promotes the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]23845766
D008767Methylmercury CompoundsMethylmercury Compounds promotes the reaction [CNTF protein results in increased expression of GFAP protein]23845766
D008767Methylmercury CompoundsMethylmercury Compounds promotes the reaction [CNTF protein results in increased expression of SOCS3 protein]23845766
D0156551-Methyl-4-phenylpyridinium[RHEB protein mutant form results in increased expression of CNTF protein] which results in decreased susceptibility to 1-Methyl-4-phenylpyridinium25799580
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D009582NitrofurantoinNitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D009582NitrofurantoinNitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]15748169
D009582NitrofurantoinRotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]15748169
D009582NitrofurantoinRotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]15748169
D009609Nitrous OxideNitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D009609Nitrous OxideNitrous Oxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]15748169
D009609Nitrous OxideNitrous Oxide results in decreased activity of CNTF protein15748169
D009609Nitrous OxideNitrous Oxide inhibits the reaction [CNTF protein results in increased activity of STAT3 protein]15748169
C025589ochratoxin Aochratoxin A results in increased expression of CNTF mRNA12700408|1841718
C029341oxophenylarsineoxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]11882386
C029341oxophenylarsineoxophenylarsine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT3 protein]11882386
D000073878Palm OilPalm Oil results in increased expression of CNTF mRNA18042831
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of CNTF mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CNTF mRNA18692542
D010862PilocarpinePilocarpine results in increased expression of CNTF mRNA10506506
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CNTF mRNA27029645
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK1 protein]15748169
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK2 protein]15748169
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]15748169
D012402RotenoneRotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]15748169
D012402RotenoneRotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]19635391
D012402RotenoneRotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]19635391
D012402RotenoneRotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]]15748169
D012402RotenoneRotenone promotes the reaction [Nitrofurantoin inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT3 protein]]15748169
D012402RotenoneRotenone results in decreased activity of CNTF protein15748169|1963539
D012402RotenoneThioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D012402RotenoneThioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]19635391
D012402RotenoneThioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein]19635391
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of CNTF mRNA21427059
C016104sodium bichromatesodium bichromate affects the expression of CNTF mRNA22110744
D0150862,6-Dichloroindophenol"2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]"19635391
D0150862,6-Dichloroindophenol"2,6-Dichloroindophenol inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]"19635391
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of CNTF protein]22150557
D013605T-2 ToxinT-2 Toxin results in increased expression of CNTF mRNA26141394
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of CNTF mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CNTF mRNA21570461
D008063Thioctic AcidThioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of CNTF protein]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of CNTF protein]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Rotenone inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]]19635391
D008063Thioctic AcidThioctic Acid inhibits the reaction [Rotenone results in decreased activity of CNTF protein]19635391
C009495titanium dioxidetitanium dioxide affects the expression of CNTF mRNA17656681
D014212Tretinoin[Tretinoin co-treated with CNTF protein] results in increased expression of PRKCD mRNA alternative form17017122
D014212Tretinoin[Tretinoin co-treated with CNTF protein] results in increased expression of TH17017122
C012589trichostatin Atrichostatin A affects the expression of CNTF mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CNTF mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of CNTF mRNA10689198|2142705
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CNTF gene25560391
D019287Zinc SulfateZinc Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]16896058
D019287Zinc SulfateZinc Sulfate inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]16896058
D015054ZymosanZymosan results in decreased expression of CNTF protein18090921
D015054ZymosanZymosan results in increased expression of CNTF mRNA17971355
D015054ZymosanZymosan results in increased expression of CNTF protein17971355

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005127ciliary neurotrophic factor receptor binding-IBA21873635  
GO:0005127ciliary neurotrophic factor receptor binding-TAS1714745  
GO:0005138interleukin-6 receptor binding-IPI12643274  
GO:0005515protein binding-IPI16051226  18775332  25416956  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-IDA12643274  
GO:0044877protein-containing complex binding-IPI10966616  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS1840538  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010628positive regulation of gene expression-IDA24129709  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0042531positive regulation of tyrosine phosphorylation of STAT protein-IDA12643274  21912637  
GO:0043524negative regulation of neuron apoptotic process-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-IDA10966616  
GO:0046533negative regulation of photoreceptor cell differentiation-IEA-  
GO:0046668regulation of retinal cell programmed cell death-IEA-  
GO:0048143astrocyte activation-IBA21873635  
GO:0048644muscle organ morphogenesis-IEA-  
GO:0048666neuron development-IEA-  
GO:0048680positive regulation of axon regeneration-IBA21873635  
GO:0070120ciliary neurotrophic factor-mediated signaling pathway-IBA21873635  
GO:0070120ciliary neurotrophic factor-mediated signaling pathway-IDA12643274  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IC12643274  
GO:0005737cytoplasm-IEA-  
GO:0030424axon-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6783589Interleukin-6 family signalingTAS
R-HSA-6788467IL-6-type cytokine receptor ligand interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21846370Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats. (2011 Aug 16)Clary CRAIDS Res Ther