Gene: CNTN1

1272
F3|GP135|MYPCN
contactin 1
protein-coding
12q12
Ensembl:ENSG00000018236 MIM:600016 Vega:OTTHUMG00000169362 UniprotKB:Q12860
NG_012058.2
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.877e-3 (AD)  8.993e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CADM20.94
LSAMP0.93
CLCN30.918
MARCH60.909
CDH20.908
OAT0.905
PEX190.903
NRCAM0.902
NDUFS10.902
ACSL30.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.683
OR4F29-0.626
CSAG1-0.423
TFPI2-0.415
SIX1-0.374
SPINK8-0.374
TRPV4-0.368
SLAMF6-0.368
CLEC6A-0.366
TNFAIP8-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA]19027725
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CNTN1 mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of CNTN1 mRNA"20713471
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CNTN1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA]19027725
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA19027725
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA]19027725
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CNTN1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CNTN1 mRNA]17585979
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]12588870
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]16949557
C025154alpha-cobratoxinalpha-cobratoxin results in decreased expression of CNTN1 mRNA12588870
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CNTN1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CNTN1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of CNTN1 mRNA26705709
C015001arsenitearsenite results in decreased expression of CNTN1 mRNA23974009
D001194AsbestosAsbestos results in decreased expression of CNTN1 mRNA22076105
D001280AtrazineAtrazine results in increased expression of CNTN1 mRNA22378314
C487081belinostatbelinostat results in increased expression of CNTN1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CNTN1 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of CNTN1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of CNTN1 protein28903499
D002038BungarotoxinsBungarotoxins inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CNTN1 mRNA]19027725
C584509C646 compoundC646 compound results in increased expression of CNTN1 mRNA26921506
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CNTN1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CNTN1 mRNA]17585979
C014347decitabinedecitabine affects the expression of CNTN1 mRNA27915011
D003907DexamethasoneDexamethasone results in decreased expression of CNTN1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CNTN1 mRNA]20032058
D002945CisplatinCisplatin results in decreased expression of CNTN1 mRNA27392435
C118739entinostatentinostat results in increased expression of CNTN1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
D007854LeadLead affects the expression of CNTN1 mRNA28903495
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]12588870
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]16949557
D008464MecamylamineMecamylamine results in increased expression of CNTN1 mRNA12588870
D008713MethimazoleMethimazole results in increased expression of CNTN1 mRNA17403546
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CNTN1 mRNA20713471
D009151Mustard GasMustard Gas results in increased expression of CNTN1 mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CNTN1 mRNA"22076105
D009532NickelNickel results in decreased expression of CNTN1 mRNA24768652|2558310
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]12588870
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]16949557
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]12588870
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]16949557
D009538NicotineNicotine results in decreased expression of CNTN1 mRNA12588870
D009538NicotineNicotine results in increased expression of CNTN1 mRNA16949557
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]12588870
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]16949557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CNTN1 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of CNTN1 mRNA26705709
C494474perchlorateperchlorate results in increased expression of CNTN1 mRNA17403546
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CNTN1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CNTN1 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of CNTN1 mRNA23557933
C043435polylactic acid-polyglycolic acid copolymer[Rotenone co-treated with polylactic acid-polyglycolic acid copolymer] results in decreased expression of CNTN1 mRNA23816754
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CNTN1 mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of CNTN1 mRNA17403546
D012402Rotenone[Rotenone co-treated with polylactic acid-polyglycolic acid copolymer] results in decreased expression of CNTN1 mRNA23816754
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CNTN1 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of CNTN1 mRNA28595984
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of CNTN1 mRNA]20032058
D013974ThyroxineThyroxine affects the expression of CNTN1 mRNA17403546
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CNTN1 mRNA20133372
C024746tobacco tartobacco tar results in decreased expression of CNTN1 mRNA19559774
D014118Toxins, Biological"Toxins, Biological affects the expression of CNTN1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of CNTN1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of CNTN1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of CNTN1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CNTN1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CNTN1 mRNA"26179874
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in decreased expression of CNTN1 mRNA]12588870
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in increased expression of CNTN1 mRNA]16949557
D014403TubocurarineTubocurarine results in decreased expression of CNTN1 mRNA16949557
D014403TubocurarineTubocurarine results in increased expression of CNTN1 mRNA12588870
D017974Uranium CompoundsUranium Compounds results in increased expression of CNTN1 mRNA19654044
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CNTN1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CNTN1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CNTN1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CNTN1 gene25560391
C025643vinclozolinvinclozolin affects the expression of CNTN1 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of CNTN1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21969550  26721881  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007219Notch signaling pathway-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0010765positive regulation of sodium ion transport-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0031175neuron projection development-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016020membrane-TAS7959734  
GO:0031225anchored component of membrane-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0045121membrane raft-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-447043Neurofascin interactionsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal