Gene: LRRIQ3

127255
LRRC44
leucine rich repeats and IQ motif containing 3
protein-coding
1p31.1
Ensembl:ENSG00000162620 MIM:617957 Vega:OTTHUMG00000009508 UniprotKB:A6PVS8
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
9.688e-1 (AD)  9.297e-1 (ND)   (Frontal_Cortex)
4.863e-1 (AD)  7.886e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17591292chr1:74180374 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANXA40.404
TNFRSF13B0.393
ZNF1850.387
LRRCC10.374
SNX60.368
KLHL50.356
KCTD180.354
ARHGEF370.354
RAI140.354
SGMS20.345

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RSPH10B-0.285
TRIML2-0.261
SLC22A9-0.251
LINC00158-0.249
FNDC8-0.24
FGF8-0.233
ADRB1-0.23
PRB1-0.228
ALDH8A1-0.227
SSX2-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of LRRIQ3 mRNA"20816883
D020106AcrylamideAcrylamide affects the expression of LRRIQ3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LRRIQ3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LRRIQ3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LRRIQ3 mRNA20106945|2163298
C006780bisphenol Abisphenol A results in increased expression of LRRIQ3 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of LRRIQ3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of LRRIQ3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LRRIQ3 mRNA24982889
D016572CyclosporineCyclosporine results in decreased expression of LRRIQ3 mRNA25562108
C039281furanfuran results in increased expression of LRRIQ3 mRNA25539665
D048628KetolidesKetolides analog results in increased expression of LRRIQ3 mRNA24967691
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of LRRIQ3 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of LRRIQ3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LRRIQ3 mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of LRRIQ3 mRNA"29244179
C006253pirinixic acidpirinixic acid results in increased expression of LRRIQ3 mRNA20813756
D011794QuercetinQuercetin results in decreased expression of LRRIQ3 mRNA21632981
D012969Sodium FluorideSodium Fluoride results in decreased expression of LRRIQ3 mRNA27862939
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LRRIQ3 mRNA21632981
D013853ThioacetamideThioacetamide results in increased expression of LRRIQ3 mRNA23411599

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal