Gene: SYT2

127833
CMS7|MYSPC|SytII
synaptotagmin 2
protein-coding
1q32.1
Ensembl:ENSG00000143858 MIM:600104 Vega:OTTHUMG00000041388 UniprotKB:Q8N9I0
NG_041776.1
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.113e-1 (AD)  7.715e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11071448chr1:202584465SYT21.200e-13Smoking27651444
cg11071448chr1:202584465SYT29.510e-10Tobacco smoking28225026
cg11071448chr1:202584465SYT21.640e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ESRRG0.876
PLEKHD10.86
NEFH0.859
AHNAK20.856
KCNA10.856
ATP8A20.85
SCN8A0.849
VAMP10.84
RIMKLA0.838
FOCAD0.837

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.579
MYL3-0.561
ROM1-0.559
YES1-0.551
S100A16-0.544
TMEM176A-0.533
PXDC1-0.53
HEY2-0.526
AKR1C3-0.517
STON2-0.515

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00042Botulinum Toxin Type BBiotechDrug93384-44-2Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased expression of SYT2 mRNA"25270620
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SYT2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SYT2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SYT2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SYT2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SYT2 mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SYT2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYT2 mRNA"27188386
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of SYT2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SYT2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SYT2 mRNA21839799
C006780bisphenol Abisphenol A affects the methylation of SYT2 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of SYT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SYT2 mRNA29097150
C013418bromfenacoumbromfenacoum results in increased expression of SYT2 protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of SYT2 mRNA26079696
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of SYT2 mRNA18636392
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYT2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SYT2 mRNA26272509
D003024ClozapineClozapine results in increased expression of SYT2 mRNA17266109
D003042CocaineCocaine results in increased expression of SYT2 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in increased expression of SYT2 mRNA]18355967
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SYT2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SYT2 mRNA26033743
D003471CuprizoneCuprizone results in increased expression of SYT2 mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SYT2 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of SYT2 mRNA23558232
D002945Cisplatintrichostatin A inhibits the reaction [Cisplatin results in decreased expression of SYT2 mRNA]23558232
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SYT2 mRNA26924002
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SYT2 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SYT2 mRNA26033743
C118739entinostatentinostat results in increased expression of SYT2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYT2 mRNA"27188386
D004397FonofosFonofos results in increased methylation of SYT2 promoter22847954
C039281furanfuran results in increased methylation of SYT2 gene22079235
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of SYT2 mRNA21782745
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of SYT2 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of SYT2 mRNA19564919
D008727MethotrexateMethotrexate affects the expression of SYT2 mRNA18502557
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of SYT2 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased methylation of SYT2 gene23303685
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SYT2 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SYT2 mRNA26924002
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of SYT2 mRNA18636392
D010278ParathionParathion results in increased methylation of SYT2 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SYT2 mRNA"25510870
D010622PhencyclidinePhencyclidine results in increased expression of SYT2 mRNA17266109
D011441PropylthiouracilPropylthiouracil results in decreased expression of SYT2 mRNA24780913
C096323rimabotulinumtoxinBrimabotulinumtoxinB binds to [trisialoganglioside GT1 co-treated with SYT2 protein modified form]27032463
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of SYT2 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of SYT2 mRNA19564919
C012568terbufosterbufos results in increased methylation of SYT2 promoter22847954
D014241TrichloroethyleneTrichloroethylene results in increased methylation of SYT2 gene27618143
C012589trichostatin Atrichostatin A inhibits the reaction [Cisplatin results in decreased expression of SYT2 mRNA]23558232
C016481trisialoganglioside GT1rimabotulinumtoxinB binds to [trisialoganglioside GT1 co-treated with SYT2 protein modified form]27032463
D014635Valproic AcidValproic Acid affects the expression of SYT2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SYT2 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005515protein binding-IPI19234194  
GO:0005544calcium-dependent phospholipid binding-IBA21873635  
GO:0005544calcium-dependent phospholipid binding-ISS-  
GO:0019905syntaxin binding-IBA21873635  
GO:0030276clathrin binding-IBA21873635  
GO:0043533inositol 1,3,4,5 tetrakisphosphate binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006906vesicle fusion-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0017158regulation of calcium ion-dependent exocytosis-IBA21873635  
GO:0048488synaptic vesicle endocytosis-IBA21873635  
GO:0048791calcium ion-regulated exocytosis of neurotransmitter-IBA21873635  
GO:0061024membrane organization-TAS-  
GO:1903861positive regulation of dendrite extension-IDA23999003  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030665clathrin-coated vesicle membrane-TAS-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0030672synaptic vesicle membrane-TAS-  
GO:0042584chromaffin granule membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemIEA
R-HSA-1643685DiseaseTAS
R-HSA-168799Neurotoxicity of clostridium toxinsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5250958Toxicity of botulinum toxin type B (BoNT/B)TAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25878287DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity. (2015 Apr 15)Barbier EJ Neurosci
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry