Gene: ADH5

128
ADH-3|ADHX|FALDH|FDH|GSH-FDH|GSNOR|HEL-S-60p
AD dehydrogenase 5 (class III), chi polypeptide
protein-coding
4q23
Ensembl:ENSG00000197894 MIM:103710 Vega:OTTHUMG00000161230 UniprotKB:P11766
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.425e-1 (AD)  2.755e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAICS0.908
SDHD0.9
CPE0.898
PRDX30.897
FAM210B0.894
GLO10.893
SRP90.886
TSPAN30.884
SDHC0.884
HIBADH0.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.801
OR4F29-0.765
FCER2-0.24
OR6C74-0.234
DPPA4-0.195
CETP-0.195
KRTAP3-2-0.194
C17orf112-0.193
KRTAP4-8-0.193
C2orf83-0.192

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03017Lauric AcidSmall Molecule143-07-7Approved|ExperimentalTarget
DB0370412-Hydroxydodecanoic AcidSmall Molecule505-95-3ExperimentalTarget
DB04153S-Hydroxymethyl GlutathioneSmall MoleculeExperimentalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
DB11077Polyethylene glycol 400Small Molecule25322-68-3ApprovedEnzyme
ID Drug Name Action PubMed
C03126312-hydroxydodecanoic acid12-hydroxydodecanoic acid binds to ADH5 protein12196016|1260420
C03126312-hydroxydodecanoic acidADH5 protein results in increased oxidation of 12-hydroxydodecanoic acid19428350
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADH5 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADH5 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ADH5 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ADH5 protein]26598702
C0293704-toluidine4-toluidine results in increased expression of ADH5 mRNA27638505
C0833778-hydroxyoctanoic acidADH5 protein results in increased oxidation of 8-hydroxyoctanoic acid19428350
D000082AcetaminophenAcetaminophen results in decreased expression of ADH5 mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of ADH5 mRNA17562736
D000438AlcoholsAlcohols results in decreased expression of ADH5 protein24300283
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ADH5 mRNA24449571
C004984apocarotenalapocarotenal results in increased expression of ADH5 mRNA17034753
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ADH5 protein]26598702
D001280AtrazineAtrazine results in decreased expression of ADH5 mRNA22378314
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ADH5 mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADH5 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADH5 mRNA22228805
D019207beta Carotenebeta Carotene results in increased expression of ADH5 mRNA17034753
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of ADH5 mRNA23041725
C099952bifenthrinbifenthrin results in increased expression of ADH5 mRNA26071804
C006780bisphenol Abisphenol A results in increased expression of ADH5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADH5 gene28505145
D002104CadmiumCadmium results in decreased expression of ADH5 mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADH5 mRNA20589742
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ADH5 gene20938992
D002927CimetidineCimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione]23220590
D002994ClofibrateClofibrate results in decreased expression of ADH5 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of ADH5 mRNA19549813
C038459curdlan[Dust co-treated with curdlan] results in increased expression of ADH5 mRNA19950363
C038459curdlan[Dust co-treated with curdlan] results in increased expression of ADH5 protein19950363
D016572CyclosporineCyclosporine results in decreased expression of ADH5 mRNA25562108
C031071decanoic aciddecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADH5 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in decreased expression of ADH5 mRNA28302478
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of ADH5 mRNA23041725
D004026DieldrinDieldrin results in increased expression of ADH5 mRNA23041725
D004147DioxinsDioxins affects the expression of ADH5 mRNA20463971
C036836dodecanedioic aciddodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D004391Dust[Dust co-treated with curdlan] results in increased expression of ADH5 mRNA19950363
D004391Dust[Dust co-treated with curdlan] results in increased expression of ADH5 protein19950363
D000431EthanolADH5 protein results in increased oxidation of Ethanol19038239
D000431EthanolS-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]19038239
D000431Ethanol[Zinc co-treated with Ethanol] results in increased expression of ADH5 mRNA19637192
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ADH5 mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADH5 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADH5 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ADH5 gene20938992
D005557FormaldehydeADH5 protein results in increased metabolism of Formaldehyde12604204
D005557FormaldehydeADH5 protein results in increased oxidation of Formaldehyde19038239
D005557FormaldehydeS-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]19038239
D005557FormaldehydeADH5 protein results in increased metabolism of Formaldehyde21920416
D005978GlutathioneGlutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D006046GoldGold results in decreased expression of ADH5 mRNA25523186
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ADH5 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADH5 mRNA25613284
C410337K 7174K 7174 results in decreased expression of ADH5 mRNA24086573
C030358lauric acidlauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ADH5 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ADH5 mRNA26011545
D026422S-NitrosoglutathioneADH5 protein results in increased reduction of S-Nitrosoglutathione19038239|1942835
D026422S-Nitrosoglutathionedecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-Nitrosoglutathionedodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-NitrosoglutathioneGlutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-Nitrosoglutathionelauric acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-Nitrosoglutathioneoctanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-Nitrosoglutathionepelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-Nitrosoglutathionesebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-NitrosoglutathioneS-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-NitrosoglutathioneS-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Ethanol]19038239
D026422S-NitrosoglutathioneS-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Formaldehyde]19038239
D026422S-NitrosoglutathioneS-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]19038239
D026422S-Nitrosoglutathioneundecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D026422S-Nitrosoglutathione[SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione26209236
C031492octanoic acidoctanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D0200031-OctanolADH5 protein results in increased metabolism of 1-Octanol19822198
D0200031-OctanolPentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol]19822198
D000442OctanolsADH5 protein results in increased oxidation of Octanols19038239
D000442OctanolsS-Nitrosoglutathione promotes the reaction [ADH5 protein results in increased oxidation of Octanols]19038239
C008776pelargonic acidpelargonic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ADH5 mRNA23948077
D010416PentachlorophenolPentachlorophenol inhibits the reaction [ADH5 protein results in increased metabolism of 1-Octanol]19822198
D010695PhlorhizinPhlorhizin results in decreased expression of ADH5 mRNA22538082
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of ADH5 mRNA22579512
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ADH5 mRNA22714537
D011374Progesterone[Progesterone results in increased activity of PGR protein] which results in increased expression of ADH5 mRNA15845616
D011794QuercetinQuercetin results in decreased expression of ADH5 mRNA21632981
C011107sebacic acidsebacic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
C029469S-hydroxymethylglutathioneADH5 protein results in increased oxidation of S-hydroxymethylglutathione23220590
C029469S-hydroxymethylglutathioneCimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione]23220590
C017514S-methyl glutathioneS-methyl glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
C009277sodium arsenatesodium arsenate results in decreased expression of ADH5 mRNA23922661
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of ADH5 mRNA21632023
D012969Sodium FluorideSodium Fluoride results in increased expression of ADH5 protein28918527
C000602674SPL-334SPL-334 results in decreased activity of ADH5 protein26209236
C000602674SPL-334[SPL-334 results in decreased activity of ADH5 protein] which results in decreased metabolism of S-Nitrosoglutathione26209236
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADH5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADH5 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADH5 mRNA25613284
D013893ThiramThiram results in decreased expression of ADH5 mRNA20530235
D014212TretinoinTretinoin results in increased expression of ADH5 mRNA23724009
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADH5 mRNA"26179874
C016173undecanoic acidundecanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione]19428350
D017974Uranium CompoundsUranium Compounds results in decreased expression of ADH5 mRNA19654044
D014520UrethaneUrethane results in decreased expression of ADH5 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ADH5 mRNA17292431
D015032Zinc[Zinc co-treated with Ethanol] results in increased expression of ADH5 mRNA19637192

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004022alcohol dehydrogenase (NAD) activity-IEA-  
GO:0005504fatty acid binding-IDA8460164  
GO:0008270zinc ion binding-IDA6375718  
GO:0009055electron transfer activity-TAS8460164  
GO:0018467formaldehyde dehydrogenase activity-IDA8460164  
GO:0042803protein homodimerization activity-IEA-  
GO:0051903S-(hydroxymethyl)glutathione dehydrogenase activity-TAS8460164  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-IEA-  
GO:0003016respiratory system process-IEA-  
GO:0006069ethanol oxidation-TAS-  
GO:0018119peptidyl-cysteine S-nitrosylation-IEA-  
GO:0022900electron transport chain-IEA-  
GO:0032496response to lipopolysaccharide-IEA-  
GO:0045777positive regulation of blood pressure-IEA-  
GO:0046294formaldehyde catabolic process-IEA-  
GO:0051409response to nitrosative stress-IEA-  
GO:0051775response to redox state-IDA8460164  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
23468174Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)Zuo LHum Genet
10697413Regulation of the mammalian alcohol dehydrogenase genes. (2000)Edenberg HJProg Nucleic Acid Res Mol Biol
1362387Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes. (1992 Dec)Edman KHum Genet
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
24397210Expression of alcoholism-relevant genes in the liver are differently correlated to different parts of the brain. (2013)Wang LGene Expr
18996923Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. (2009 Feb 1)Macgregor SHum Mol Genet
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res
23456092Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)Park BLHum Genet
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
17185388Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (2007 Feb 15)Luo XHum Mol Genet
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res
28937693Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)Clarke TKMol Psychiatry