Gene info: ID 1281

Gene: COL3A1

GENE ID: 1281

Synonyms: EDS4A|EDSVASC

Description: collagen type III alpha 1 chain

Gene type: protein-coding

Location: 2q32.2

dbXrefs: Ensembl:ENSG00000168542 MIM:120180 Vega:OTTHUMG00000132648 UniprotKB:P02461

RefSeq: NG_007404.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.984e-1 (AD) 2.016e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COL14A1	0.87
COL8A1	0.864
COL6A3	0.857
MGP	0.851
GPX8	0.833
COL1A2	0.823
GJA5	0.813
LUM	0.81
TBX18	0.804
COL1A1	0.796

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASPDH	-0.407
DBP	-0.384
TMEM53	-0.375
HAGHL	-0.374
MYH7B	-0.37
CCDC24	-0.366
FAM43B	-0.365
ABCB9	-0.364
HAS1	-0.363
MYADML2	-0.362

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00048	Collagenase clostridium histolyticum	BiotechDrug	9001-12-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C549500	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea	1-(2-bromophenyl)-3-(7-cyano-3H-benzotriazol-4-yl)urea inhibits the reaction [AGT protein modified form results in increased expression of COL3A1 mRNA]	27678262
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of COL3A1 mRNA"	19162173
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	25827057
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of COL3A1 mRNA]	27025157
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of COL3A1 protein	27595240
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	CTNNB1 protein affects the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in increased expression of COL3A1 protein]	27595240
C502971	2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine	2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine inhibits the reaction [Dimethylnitrosamine results in increased expression of COL3A1 mRNA]	15723089
C028451	3,4,3',4'-tetrachlorobiphenyl	"3,4,3',4'-tetrachlorobiphenyl affects the expression of COL3A1 mRNA"	20638727
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of COL3A1 mRNA"	23196670
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of COL3A1 mRNA"	20959002
C520164	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid co-treated with Carbon Tetrachloride] results in increased expression of COL3A1 protein	12512042
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of COL3A1 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL3A1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL3A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL3A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL3A1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of COL3A1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in increased expression of COL3A1 mRNA	28286204
D000082	Acetaminophen	EGR1 protein affects the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]	28286204
D000082	Acetaminophen	MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]	18700144
C056165	acetovanillone	acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]	16531806
C056165	acetovanillone	acetovanillone inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]	16531806
D020106	Acrylamide	Acrylamide results in decreased expression of COL3A1 mRNA	28959563
C526957	alisol B 23-acetate	alisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]	28578904
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of COL3A1 mRNA	16483693
C053506	ammonium perchlorate	ammonium perchlorate results in increased expression of COL3A1 mRNA	17456394
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of COL3A1 mRNA"	22863853
D000806	Angiotensin-Converting Enzyme Inhibitors	Angiotensin-Converting Enzyme Inhibitors results in decreased expression of COL3A1 mRNA	15667801
C025657	arsenic acid	arsenic acid results in increased expression of COL3A1 mRNA	18296743
C025657	arsenic acid	Dietary Fats promotes the reaction [arsenic acid results in increased expression of COL3A1 mRNA]	18296743
C015001	arsenite	arsenite results in increased expression of COL3A1 mRNA	18296743
C015001	arsenite	Dietary Fats promotes the reaction [arsenite results in increased expression of COL3A1 mRNA]	18296743
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of COL3A1 mRNA"	19219932
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of COL3A1 mRNA"	22251266
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of COL3A1 mRNA"	11250057
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of COL3A1 mRNA"	18192500
D017638	Asbestos, Crocidolite	"MAP2K1 protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of COL3A1 mRNA]"	18192500
C011669	ascorbate-2-phosphate	ascorbate-2-phosphate results in decreased expression of COL3A1 mRNA	17306970
C011669	ascorbate-2-phosphate	ascorbate-2-phosphate results in increased expression of COL3A1 mRNA	17306970
D001241	Aspirin	Aspirin results in decreased expression of COL3A1 mRNA	15456535
C020976	azelastine	azelastine results in decreased expression of COL3A1 mRNA	8919039
C547126	AZM551248	AZM551248 results in increased expression of COL3A1 mRNA	22323515
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COL3A1 mRNA	27858113
D001554	Benzene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of COL3A1 mRNA	17905399
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COL3A1 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of COL3A1 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of COL3A1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of COL3A1 mRNA	22342234
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COL3A1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of COL3A1 mRNA	20713471\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of COL3A1 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of COL3A1 mRNA"	20382639
D004958	Estradiol	Estradiol results in increased expression of COL3A1 mRNA	15902152
D004958	Estradiol	Estradiol affects the expression of COL3A1 protein	20864640
D004958	Estradiol	Estradiol results in increased expression of COL3A1 mRNA	19484750
D001663	Bilirubin	Bilirubin results in decreased expression of COL3A1 mRNA	20196124
C006780	bisphenol A	bisphenol A results in decreased expression of COL3A1 mRNA	27809950
C006780	bisphenol A	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of COL3A1 mRNA]	27025157
C006780	bisphenol A	bisphenol A affects the expression of COL3A1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of COL3A1 mRNA	27025157
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in increased expression of COL3A1 mRNA]	27025157
D001761	Bleomycin	MIR101-1 mRNA inhibits the reaction [Bleomycin results in increased expression of COL3A1 mRNA]	28726637
D001761	Bleomycin	Bleomycin results in increased expression of COL3A1 mRNA	26817844\|2872663
D001761	Bleomycin	Bleomycin results in decreased expression of COL3A1 protein	25933445
D000551	Ambroxol	Ambroxol affects the reaction [Paraquat results in increased expression of COL3A1 mRNA]	21921364
D002065	Buspirone	Buspirone results in decreased expression of COL3A1 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of COL3A1 mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of COL3A1 mRNA	12160620
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of COL3A1 mRNA	24982889
C077793	candesartan cilexetil	candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of COL3A1 protein]	27889505
D002211	Capsaicin	Capsaicin results in increased expression of COL3A1 mRNA	20349343
D002244	Carbon	"[Carbon co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of COL3A1 mRNA"	26880698
D002244	Carbon	Carbon results in increased expression of COL3A1 mRNA	26880698
D002251	Carbon Tetrachloride	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of COL3A1 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of COL3A1 mRNA	15056808\|1826369
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of COL3A1 protein	27477297
D002251	Carbon Tetrachloride	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]	27477297
D002251	Carbon Tetrachloride	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]	27477297
D002251	Carbon Tetrachloride	[4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid co-treated with Carbon Tetrachloride] results in increased expression of COL3A1 protein	12512042
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of COL3A1 mRNA	16239168
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of COL3A1 mRNA	12632512\|1715783
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of COL3A1 protein	17157831\|2350077
D002251	Carbon Tetrachloride	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	22683883
D002251	Carbon Tetrachloride	"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]"	12632512
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	17157831
D002251	Carbon Tetrachloride	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]	17157831
D002251	Carbon Tetrachloride	PLAU protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	18481824
D002251	Carbon Tetrachloride	puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]	23500774
C043211	carvedilol	carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]	10722803
C043211	carvedilol	"carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA]"	11682445
C043211	carvedilol	carvedilol results in decreased expression of COL3A1 protein	11181017
D002737	Chloroprene	Chloroprene results in decreased expression of COL3A1 mRNA	23125180
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D002793	Cholic Acids	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D002793	Cholic Acids	[Methyltestosterone co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL3A1 mRNA	20548288\|2093899
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL3A1 mRNA	22915297
D002794	Choline	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL3A1 mRNA]	22915297
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COL3A1 mRNA	27858113
D002995	Clofibric Acid	Clofibric Acid affects the expression of COL3A1 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of COL3A1 mRNA	21139344
D003042	Cocaine	Cocaine results in increased expression of COL3A1 mRNA	9455993
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of COL3A1 mRNA	24690739
D003300	Copper	Copper deficiency results in increased expression of COL3A1 mRNA	17418555
D003474	Curcumin	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	22683883
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D003561	Cytarabine	Cytarabine results in decreased expression of COL3A1 mRNA	21198554
D000069439	Dasatinib	Dasatinib results in increased expression of COL3A1 mRNA	20579391
D003907	Dexamethasone	Dexamethasone results in decreased expression of COL3A1 mRNA	25047013
D003907	Dexamethasone	Dexamethasone results in decreased expression of COL3A1 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of COL3A1 mRNA]	20032058
D003994	Bucladesine	Bucladesine inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]	11576339
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] affects the expression of COL3A1 mRNA	20705681
D002945	Cisplatin	COL3A1 mRNA results in decreased susceptibility to Cisplatin	25199881
D004008	Diclofenac	Diclofenac results in decreased expression of COL3A1 mRNA	26934552
D019259	Lamivudine	Lamivudine results in decreased expression of COL3A1 protein	11738102
D004041	Dietary Fats	Dietary Fats promotes the reaction [arsenic acid results in increased expression of COL3A1 mRNA]	18296743
D004041	Dietary Fats	Dietary Fats promotes the reaction [arsenite results in increased expression of COL3A1 mRNA]	18296743
D004041	Dietary Fats	Dietary Fats results in decreased expression of COL3A1 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of COL3A1 mRNA	18296743\|2260994
D004041	Dietary Fats	"carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA]"	11682445
D004041	Dietary Fats	[Ethanol co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA	21051528
D004041	Dietary Fats	"[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA"	11682445
D004041	Dietary Fats	Dietary Fats results in increased expression of COL3A1 mRNA	21852083
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats results in increased expression of COL3A1 mRNA]	21852083
C058705	diethyl malate	diethyl malate affects the expression of COL3A1 mRNA	24814887
C014476	diethyl maleate	diethyl maleate results in decreased expression of COL3A1 mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of COL3A1 mRNA	19638242
D002117	Calcitriol	Calcitriol results in decreased expression of COL3A1 mRNA	26485663
D004128	Dimethylnitrosamine	2-phenyl-4-(3-pyridin-2-yl-1H-pyrazol-4-yl)pyridine inhibits the reaction [Dimethylnitrosamine results in increased expression of COL3A1 mRNA]	15723089
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of COL3A1 mRNA	15723089
D004164	Diphosphonates	Diphosphonates results in decreased expression of COL3A1 mRNA	19597852
D004176	Dipyridamole	Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]	11576339
D004176	Dipyridamole	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]	11576339
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of COL3A1 mRNA	24690739
D004237	Diuron	Diuron results in decreased expression of COL3A1 mRNA	25152437
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA]	28987794
D004317	Doxorubicin	COL3A1 mRNA results in decreased susceptibility to Doxorubicin	25199881
D004317	Doxorubicin	Doxorubicin results in decreased expression of COL3A1 mRNA	16243910\|1788872
D004317	Doxorubicin	Doxorubicin results in increased expression of COL3A1 mRNA	15033991
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of COL3A1 mRNA	21040762
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]"	12632512
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Thioacetamide results in increased expression of COL3A1 mRNA]"	17629604
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in decreased expression of COL3A1 mRNA"	12076858
D004642	Emodin	Emodin results in decreased expression of COL3A1 mRNA	15288473
D004656	Enalapril	Enalapril results in increased expression of COL3A1 mRNA	25037058
D004656	Enalapril	Enalapril results in decreased expression of COL3A1 mRNA	17164399
C034959	enterotoxin C, staphylococcal	"enterotoxin C, staphylococcal analog inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]"	26099602
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of COL3A1 protein]	22101032
C015860	ergosta-4,6,8(14),22-tetraen-3-one	"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]"	28578904
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased expression of COL3A1 mRNA	14967907
D000431	Ethanol	[Ethanol co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA	21051528
D000431	Ethanol	Ethanol results in increased expression of COL3A1 protein	23274713
D000431	Ethanol	Genistein inhibits the reaction [Ethanol results in increased expression of COL3A1 protein]	23274713
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of COL3A1 mRNA	17557909
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of COL3A1 mRNA	28189721
D018690	Excitatory Amino Acid Agonists	Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA]	28987794
D018690	Excitatory Amino Acid Agonists	Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA	28987794
D018690	Excitatory Amino Acid Agonists	U 0126 inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA]	28987794
C049347	fasudil	fasudil results in decreased expression of COL3A1 mRNA	22465603
D011345	Fenofibrate	Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL3A1 mRNA]	28871336
D000068876	Fingolimod Hydrochloride	Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]	24893116
D005472	Fluorouracil	COL3A1 protein affects the susceptibility to Fluorouracil	16217747
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL3A1 mRNA	20548288\|2093899
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in increased expression of COL3A1 mRNA]	27025157
C039281	furan	furan results in increased expression of COL3A1 mRNA	27387713
D005688	Galactosamine	Galactosamine results in increased expression of COL3A1 mRNA	27876602
D005688	Galactosamine	Genistein inhibits the reaction [Galactosamine results in increased expression of COL3A1 mRNA]	27876602
D019833	Genistein	Genistein inhibits the reaction [Ethanol results in increased expression of COL3A1 protein]	23274713
D019833	Genistein	Genistein inhibits the reaction [Galactosamine results in increased expression of COL3A1 mRNA]	27876602
D005938	Glucocorticoids	Glucocorticoids results in decreased expression of COL3A1 mRNA	16023836
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in decreased expression of COL3A1 mRNA]	17109745
D005947	Glucose	Glucose deficiency affects the secretion of COL3A1 protein	24802182
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of COL3A1 mRNA	22634610
D005947	Glucose	[INS protein co-treated with Glucose] results in increased expression of COL3A1 mRNA	22634610
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA	19695318
D006118	Griseofulvin	Griseofulvin results in increased expression of COL3A1 mRNA	12735108
D017313	Fenretinide	Fenretinide results in decreased expression of COL3A1 mRNA	28973697
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]	28578904
C492448	ICG 001	Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]	28578904
C078038	inchinko-to	inchinko-to results in decreased expression of COL3A1 mRNA	15288473
D007213	Indomethacin	Indomethacin results in increased expression of COL3A1 mRNA	18299717
D007545	Isoproterenol	AGT inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein]	20409916
D007545	Isoproterenol	Isoproterenol results in increased expression of COL3A1 mRNA	9559417
D007545	Isoproterenol	Isoproterenol results in increased expression of COL3A1 protein	20409916
D007545	Isoproterenol	manidipine inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]	9559417
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of COL3A1 mRNA	26752646
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of COL3A1 mRNA	26644586
C008281	limonene	limonene results in increased expression of COL3A1 mRNA	12815608
C482199	lipopolysaccharide, E coli O55-B5	"[Carbon co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of COL3A1 mRNA"	26880698
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of COL3A1 mRNA"	26880698
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of COL3A1 mRNA	23585870\|2733941
D008070	Lipopolysaccharides	Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]	23585870
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of COL3A1 mRNA]	17621560
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]	28578904
D019808	Losartan	Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]	28578904
D019808	Losartan	Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]	23585870
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]	16539842
D019808	Losartan	Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]	25233898
D019808	Losartan	Losartan results in decreased expression of COL3A1 mRNA	15100363
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of COL3A1 mRNA	26378955
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of COL3A1 mRNA	26378955
C054218	manidipine	manidipine inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]	9559417
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL3A1 mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in decreased expression of COL3A1 mRNA	19564919
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL3A1 mRNA	20548288\|2093899
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL3A1 mRNA	22915297
D008715	Methionine	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL3A1 mRNA]	22915297
D008727	Methotrexate	COL3A1 mRNA results in decreased susceptibility to Methotrexate	25199881
D008727	Methotrexate	Methotrexate affects the expression of COL3A1 protein alternative form	15787813
D008727	Methotrexate	Methotrexate results in increased expression of COL3A1 protein	7577576\|8667468
D008727	Methotrexate	Methotrexate results in increased expression of COL3A1 protein alternative form	2297495\|2566230
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of COL3A1 mRNA	20713471
C030957	methylmercury II	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of COL3A1 mRNA	17905399
D008777	Methyltestosterone	[Methyltestosterone co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D015735	Mifepristone	Mifepristone results in decreased expression of COL3A1 mRNA	25972201
C028577	monobutyl phthalate	monobutyl phthalate affects the expression of COL3A1 mRNA	19162170
C063509	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]	11576339
C028473	N-acetyl-4-benzoquinoneimine	N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA	28286204
C003297	nandrolone decanoate	nandrolone decanoate results in increased expression of COL3A1 mRNA	17906098
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of COL3A1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of COL3A1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of COL3A1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of COL3A1 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of COL3A1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of COL3A1 mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of COL3A1 mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of COL3A1 mRNA	24136188
C045863	neo-gambogic acid	neo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL3A1 protein]	27616297
D009532	Nickel	Nickel results in increased expression of COL3A1 mRNA	12540486
C022838	nickel chloride	nickel chloride affects the expression of COL3A1 mRNA	22110744
C029938	nickel sulfate	nickel sulfate results in decreased expression of COL3A1 mRNA	16166746
C012655	nimesulide	nimesulide results in decreased expression of COL3A1 mRNA	24136188
D009638	Norepinephrine	carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]	10722803
D009638	Norepinephrine	Norepinephrine results in increased expression of COL3A1 mRNA	10722803\|1457759
D019787	Linoleic Acid	Linoleic Acid results in decreased expression of COL3A1 mRNA	26240151
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of COL3A1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of COL3A1 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of COL3A1 mRNA	24236059
D010100	Oxygen	Oxygen deficiency results in increased expression of COL3A1 mRNA	24205000
D010126	Ozone	Ozone results in increased expression of COL3A1 mRNA	9820643
D010126	Ozone	Ozone results in increased expression of COL3A1 mRNA	16716893\|8018336
C102487	pachymic acid	pachymic acid analog inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]	28578904
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] affects the expression of COL3A1 mRNA	20705681
D017239	Paclitaxel	COL3A1 mRNA results in decreased susceptibility to Paclitaxel	25199881
D000073878	Palm Oil	Palm Oil results in decreased expression of COL3A1 mRNA	18042831
D010269	Paraquat	ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]	25945502
D010269	Paraquat	ADIPOR1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]]	25945502
D010269	Paraquat	Paraquat results in increased expression of COL3A1 mRNA	20035857\|2594550
D010269	Paraquat	Saralasin inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]	20035857
D010269	Paraquat	"enterotoxin C, staphylococcal analog inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]"	26099602
D010269	Paraquat	Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]	24893116
D010269	Paraquat	Paraquat results in increased expression of COL3A1 mRNA	24893116\|2530496
D010269	Paraquat	"plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]"	26758514
D010269	Paraquat	Ambroxol affects the reaction [Paraquat results in increased expression of COL3A1 mRNA]	21921364
D010269	Paraquat	Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]	25233898
D010269	Paraquat	Paraquat results in increased expression of COL3A1 mRNA	21921364\|2587330
D010269	Paraquat	Paraquat results in increased expression of COL3A1 protein	25233898
C084656	paricalcitol	paricalcitol results in increased expression of COL3A1 mRNA	25037058
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of COL3A1 mRNA	26705709
D010431	Pentoxifylline	Pentoxifylline results in decreased expression of COL3A1 protein	11788567
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in decreased expression of COL3A1 mRNA	22790973
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of COL3A1 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of COL3A1 mRNA	19162173
D020913	Perindopril	Perindopril results in decreased expression of COL3A1 mRNA	12076858\|1487103
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL3A1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of COL3A1 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of COL3A1 mRNA	17426115\|1844570
C442842	plant extract, Puerariae Radix	"plant extract, Puerariae Radix inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]"	26758514
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]	17157831
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]	17157831
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA	19695318
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of COL3A1 protein	23718831
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of COL3A1 mRNA	23608068
D011374	Progesterone	Progesterone affects the expression of COL3A1 protein	20864640
D011441	Propylthiouracil	Propylthiouracil affects the expression of COL3A1 mRNA	24780913
C033607	puerarin	puerarin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]	23500774
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of COL3A1 mRNA	9527400
D011765	Pyruvaldehyde	epigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of COL3A1 protein]	22101032
D011765	Pyruvaldehyde	Pyruvaldehyde results in increased expression of COL3A1 protein	22101032
D011794	Quercetin	Quercetin results in decreased expression of COL3A1 mRNA	12653748\|1708674
D011794	Quercetin	Quercetin results in decreased expression of COL3A1 protein	12653748\|1708674
D011794	Quercetin	Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL3A1 mRNA]	22915297
C012526	quercitrin	quercitrin results in decreased expression of COL3A1 mRNA	25193878
C052785	rebamipide	rebamipide results in increased expression of COL3A1 mRNA	18299717
C059514	resveratrol	resveratrol affects the secretion of COL3A1 protein	24802182
C059514	resveratrol	resveratrol results in decreased expression of COL3A1 mRNA	24317052
C059514	resveratrol	resveratrol results in increased expression of COL3A1 protein	22936809
C059514	resveratrol	resveratrol inhibits the reaction [DMD gene mutant form results in increased expression of COL3A1 mRNA]	23297412
C059514	resveratrol	resveratrol results in decreased expression of COL3A1 mRNA	25394648
C059514	resveratrol	resveratrol results in decreased expression of COL3A1 mRNA	19228061
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats results in increased expression of COL3A1 mRNA]	21852083
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in decreased expression of COL3A1 protein]	22936809
D015474	Isotretinoin	Isotretinoin results in decreased expression of COL3A1 mRNA	15972972
D015474	Isotretinoin	Isotretinoin results in decreased expression of COL3A1 protein	15972972
C089730	rosiglitazone	rosiglitazone inhibits the reaction [AGT protein results in increased expression of COL3A1 mRNA]	18278065
C089730	rosiglitazone	rosiglitazone results in increased expression of COL3A1 mRNA	19397913
C041376	rosmarinic acid	rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]	28789951
C041376	rosmarinic acid	rosmarinic acid results in decreased expression of COL3A1 mRNA	28789951
D012504	Saralasin	Saralasin inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA]	20035857
D012524	Sarin	Sarin results in decreased expression of COL3A1 mRNA	19522546
C534628	SCH 23390	SCH 23390 results in decreased expression of COL3A1 mRNA	19564919
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of COL3A1 mRNA"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of COL3A1 mRNA]"	21514415
C016101	shikonin	shikonin results in decreased expression of COL3A1 mRNA	25591861
D012822	Silicon Dioxide	HMGB1 protein promotes the reaction [[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL3A1 protein]	27616297
D012822	Silicon Dioxide	IL1B protein affects the reaction [Silicon Dioxide analog results in increased expression of COL3A1 mRNA]	25388157
D012822	Silicon Dioxide	neo-gambogic acid inhibits the reaction [[Silicon Dioxide results in increased expression of HMGB1 protein] which results in increased expression of COL3A1 protein]	27616297
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of COL3A1 mRNA	25388157
D012822	Silicon Dioxide	[Silicon Dioxide results in increased secretion of HMGB1 protein] which results in increased expression of COL3A1 protein	27616297
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of COL3A1 mRNA	22431001
D019821	Simvastatin	Simvastatin results in increased expression of COL3A1 mRNA	17183729
D019821	Simvastatin	Simvastatin results in increased expression of COL3A1 mRNA	10412775\|1627430
D019821	Simvastatin	Simvastatin results in decreased expression of COL3A1 mRNA	16414398
C017947	sodium arsenite	sodium arsenite results in decreased expression of COL3A1 mRNA	18812580
C017947	sodium arsenite	sodium arsenite results in decreased expression of COL3A1 protein	19095001
C017947	sodium arsenite	sodium arsenite results in increased expression of COL3A1 mRNA	19095001
C017947	sodium arsenite	candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of COL3A1 protein]	27889505
C017947	sodium arsenite	sodium arsenite results in decreased expression of COL3A1 mRNA	19072884
C017947	sodium arsenite	sodium arsenite results in increased expression of COL3A1 protein	27889505
D012982	Sodium, Dietary	"carvedilol inhibits the reaction [[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA]"	11682445
D012982	Sodium, Dietary	"[Sodium, Dietary co-treated with Dietary Fats] results in increased expression of COL3A1 mRNA"	11682445
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of COL3A1 mRNA	24383545
C471405	sorafenib	sorafenib inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 protein]	21360571
D013148	Spironolactone	Spironolactone results in decreased expression of COL3A1 protein alternative form	11300427
D013148	Spironolactone	Spironolactone results in decreased expression of COL3A1 protein modified form	15842549\|9302344
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of COL3A1 mRNA	26378955
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of COL3A1 mRNA	26378955
D013629	Tamoxifen	Tamoxifen affects the expression of COL3A1 mRNA	14699072
D013629	Tamoxifen	Tamoxifen affects the expression of COL3A1 mRNA	20937368
D013739	Testosterone	Testosterone results in increased expression of COL3A1 mRNA	21475673
D013739	Testosterone	Testosterone results in increased expression of COL3A1 protein modified form	21475673
D013739	Testosterone	Testosterone affects the expression of COL3A1 mRNA	20403060
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of COL3A1 mRNA]	20032058
C004648	testosterone enanthate	testosterone enanthate affects the expression of COL3A1 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of COL3A1 mRNA]	14728982
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of COL3A1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of COL3A1 mRNA]	15667827
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of COL3A1 mRNA	24035824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COL3A1 mRNA	14728982\|2771310
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COL3A1 mRNA	15644576\|2095900
C017953	tetramethylpyrazine	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]	27477297
D013853	Thioacetamide	"Drugs, Chinese Herbal inhibits the reaction [Thioacetamide results in increased expression of COL3A1 mRNA]"	17629604
D013853	Thioacetamide	Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of COL3A1 mRNA]	17621560
D013853	Thioacetamide	Thioacetamide results in increased expression of COL3A1 mRNA	17621560\|1762960
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of COL3A1 protein	22761892
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of COL3A1 mRNA	22761892\|2811129
D019772	Topotecan	COL3A1 mRNA results in decreased susceptibility to Topotecan	25199881
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of COL3A1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of COL3A1 mRNA	25729387
D014112	Toxaphene	Toxaphene results in increased expression of COL3A1 mRNA	23153324
D014118	Toxins, Biological	"Toxins, Biological affects the expression of COL3A1 mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of COL3A1 mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of COL3A1 protein	1708081
D014212	Tretinoin	Tretinoin inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]	16539842
D014241	Trichloroethylene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of COL3A1 mRNA	17905399
C012589	trichostatin A	trichostatin A results in increased expression of COL3A1 mRNA	23463510
C012589	trichostatin A	trichostatin A results in decreased expression of COL3A1 mRNA	15901671
D014403	Tubocurarine	Tubocurarine results in decreased expression of COL3A1 mRNA	19728367
D017973	Tungsten Compounds	Tungsten Compounds results in decreased expression of COL3A1 mRNA	28666766
C113580	U 0126	U 0126 inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA]	28987794
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of COL3A1 mRNA	18479249
D014635	Valproic Acid	Valproic Acid affects the expression of COL3A1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of COL3A1 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of COL3A1 mRNA	24896083
D014635	Valproic Acid	Valproic Acid results in decreased expression of COL3A1 mRNA	15901671
C066075	vanadium pentoxide	vanadium pentoxide results in decreased expression of COL3A1 mRNA	17459161
D014640	Vancomycin	Vancomycin results in decreased expression of COL3A1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of COL3A1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of COL3A1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of COL3A1 mRNA	23034163
D014750	Vincristine	COL3A1 mRNA results in decreased susceptibility to Vincristine	25199881
C029297	vinylidene chloride	vinylidene chloride results in increased expression of COL3A1 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of COL3A1 mRNA	20060208
D015032	Zinc	Zinc deficiency results in increased expression of COL3A1 mRNA	18356318
C088658	zoledronic acid	Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL3A1 mRNA]	28871336
C088658	zoledronic acid	SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL3A1 mRNA]	28871336
C088658	zoledronic acid	zoledronic acid results in increased expression of COL3A1 mRNA	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	19932771
GO:0005178	integrin binding	-	IMP	9573018
GO:0005178	integrin binding	-	NAS	14970208
GO:0005201	extracellular matrix structural constituent	-	IBA	21873635
GO:0005201	extracellular matrix structural constituent	-	IMP	7487954 9036918
GO:0005515	protein binding	-	IPI	2839553 16754721 16912226 20015075
GO:0030020	extracellular matrix structural constituent conferring tensile strength	-	HDA	27559042
GO:0046332	SMAD binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0048407	platelet-derived growth factor binding	-	IDA	8900172

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001501	skeletal system development	-	IEA	-
GO:0007160	cell-matrix adhesion	-	IDA	16912226
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IDA	16360482
GO:0007229	integrin-mediated signaling pathway	-	IMP	14970208
GO:0007507	heart development	-	IMP	7546986
GO:0007568	aging	-	IEA	-
GO:0009314	response to radiation	-	IDA	14736764
GO:0009612	response to mechanical stimulus	-	IEA	-
GO:0018149	peptide cross-linking	-	IDA	16754721
GO:0021987	cerebral cortex development	-	ISS	-
GO:0030168	platelet activation	-	NAS	9573018
GO:0030198	extracellular matrix organization	-	IBA	21873635
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0030199	collagen fibril organization	-	IMP	7546986 9036918
GO:0030199	collagen fibril organization	-	NAS	1672129
GO:0034097	response to cytokine	-	IDA	9076960 16360482
GO:0035025	positive regulation of Rho protein signal transduction	-	ISS	-
GO:0042060	wound healing	-	IDA	1466622
GO:0042060	wound healing	-	NAS	14736764
GO:0043588	skin development	-	IMP	9036918
GO:0048565	digestive tract development	-	IEA	-
GO:0050776	regulation of immune response	-	TAS	-
GO:0050777	negative regulation of immune response	-	IMP	16754721
GO:0060414	aorta smooth muscle tissue morphogenesis	-	IEA	-
GO:0071230	cellular response to amino acid stimulus	-	IEA	-
GO:0097435	supramolecular fiber organization	-	IMP	14970208
GO:2001223	negative regulation of neuron migration	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	TAS	-
GO:0005586	collagen type III trimer	-	IBA	21873635
GO:0005586	collagen type III trimer	-	IDA	19932771
GO:0005586	collagen type III trimer	-	IMP	7487954 17576241
GO:0005586	collagen type III trimer	-	NAS	1672129
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	7487954
GO:0005615	extracellular space	-	NAS	9036918
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0031012	extracellular matrix	-	IMP	7487954 14970208
GO:0062023	collagen-containing extracellular matrix	-	HDA	27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	TAS	22261194

KEGG ID	KEGG Term
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04974	Protein digestion and absorption
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474290	Collagen formation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	TAS
R-HSA-168256	Immune System	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	IEA
R-HSA-3000170	Syndecan interactions	IEA
R-HSA-3000171	Non-integrin membrane-ECM interactions	TAS
R-HSA-3000171	Non-integrin membrane-ECM interactions	IEA
R-HSA-3000178	ECM proteoglycans	TAS
R-HSA-3000178	ECM proteoglycans	IEA
R-HSA-3000480	Scavenging by Class A Receptors	IEA
R-HSA-375165	NCAM signaling for neurite out-growth	TAS
R-HSA-419037	NCAM1 interactions	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-6806834	Signaling by MET	TAS
R-HSA-8874081	MET activates PTK2 signaling	TAS
R-HSA-8875878	MET promotes cell motility	TAS
R-HSA-8948216	Collagen chain trimerization	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
12798348	Molecular pathogenesis of subarachnoid haemorrhage. (2003 Sep)	Zhang B	Int J Biochem Cell Biol
21514415	Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis. (2011 May)	Sabo-Attwood T	Am J Pathol
29614203	Changes in the expression of matrix extracellular genes and TGFB family members in rotator cuff tears. (2018 Apr 3)	Belangero PS	J Orthop Res
26741506	Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. (2016 Feb 23)	Wang XQ	Oncotarget