Gene: EDARADD

128178
ECTD11A|ECTD11B|ED3|EDA3
EDAR associated death domain
protein-coding
1q42.3-q43
Ensembl:ENSG00000186197 MIM:606603 Vega:OTTHUMG00000039954 UniprotKB:Q8WWZ3
NG_011566.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.509e-1 (AD)  4.895e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00178850chr1:236559675EDARADD1.200e-12Smoking27651444
cg15677293chr1:236559595EDARADD6.200e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPATA210.467
KHDC3L0.458
SMR3A0.45
CST9L0.424
RSPH4A0.413
SSX70.413
AWAT10.412
HHLA20.412
NUSAP10.405
TAAR80.404

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHAD-0.218
INSL5-0.211
GPR17-0.209
APOA1-0.203
TSPAN16-0.195
GVQW1-0.193
KRT83-0.189
KRTAP10-12-0.185
LAIR2-0.184
ATP2C2-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of EDARADD mRNA"20406850
C0038982-anisidine2-anisidine affects the expression of EDARADD mRNA28089782
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]"23452621
C406592azaspiracidazaspiracid results in increased expression of EDARADD mRNA28939011
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EDARADD mRNA22228805
D004958EstradiolEstradiol affects the expression of EDARADD mRNA23557687
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of EDARADD mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of EDARADD mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of EDARADD mRNA25181051|2698221
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDARADD mRNA28628672
D000069286BortezomibBortezomib results in increased expression of EDARADD mRNA17895889
C584509C646 compoundC646 compound results in increased expression of EDARADD mRNA26191083
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDARADD mRNA28628672
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
C492448ICG 001ICG 001 results in increased expression of EDARADD mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDARADD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of EDARADD mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EDARADD mRNA25307878
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of EDARADD mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDARADD mRNA]"23090859
C022838nickel chloride"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDARADD mRNA]"23090859
C029938nickel sulfatenickel sulfate results in increased expression of EDARADD mRNA22714537
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of EDARADD mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
D052638Particulate MatterParticulate Matter results in decreased expression of EDARADD mRNA22178795
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of EDARADD mRNA]23452621
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EDARADD mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of EDARADD mRNA"26179874
D014520UrethaneUrethane results in decreased expression of EDARADD mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of EDARADD mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0032502developmental process-IBA21873635  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28874809Forensic age prediction for saliva samples using methylation-sensitive high resolution melting: exploratory application for cigarette butts. (2017 Sep 5)Hamano YSci Rep