Gene info: ID 1282

Gene: COL4A1

GENE ID: 1282

Synonyms: BSVD|RATOR

Description: collagen type IV alpha 1 chain

Gene type: protein-coding

Location: 13q34

dbXrefs: Ensembl:ENSG00000187498 MIM:120130 Vega:OTTHUMG00000017342 UniprotKB:P02462

RefSeq: NG_011544.2

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.344e-1 (AD) 5.481e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs672949	chr13:110227207 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COL4A2	0.952
ITGB3	0.908
ADAMTS9	0.887
CD93	0.881
S1PR3	0.877
IL1R1	0.868
CASP4	0.865
RAB27A	0.849
ANXA2	0.848
ITGA5	0.845

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NEUROD6	-0.456
TMEM179	-0.453
KCNIP3	-0.453
MARCH4	-0.441
ZSCAN1	-0.439
SLC7A4	-0.437
SPEF1	-0.436
MYADML2	-0.435
KCNK4	-0.434
SMIM18	-0.427

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of COL4A1 mRNA"	26377693
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of COL4A1 mRNA"	23829299
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of COL4A1 mRNA"	25710175
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of COL4A1 mRNA	22193206
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of COL4A1 mRNA"	23829299
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of COL4A1 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL4A1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL4A1 mRNA"	27188386
D000079	Acetaldehyde	Acetaldehyde results in decreased expression of COL4A1 mRNA	8135774
D000079	Acetaldehyde	Acetaldehyde results in decreased expression of COL4A1 protein	8135774
D000079	Acetaldehyde	TGFB1 protein inhibits the reaction [Acetaldehyde results in decreased expression of COL4A1 protein]	8135774
D000082	Acetaminophen	Acetaminophen results in decreased expression of COL4A1 mRNA	26690555
D000082	Acetaminophen	Acetaminophen results in increased expression of COL4A1 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of COL4A1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of COL4A1 mRNA	11264010\|1942001
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of COL4A1 mRNA	16084531
C106812	adefovir dipivoxil	adefovir dipivoxil results in decreased expression of COL4A1 mRNA	25596134
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of COL4A1 gene	27153756
D000450	Aldosterone	Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]	18682491
D000450	Aldosterone	Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D000450	Aldosterone	[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D000450	Aldosterone	eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of COL4A1 mRNA	16483693
C004984	apocarotenal	apocarotenal results in decreased expression of COL4A1 mRNA	17034753
D001151	Arsenic	Arsenic affects the methylation of COL4A1 gene	25304211
D001507	Beclomethasone	Beclomethasone results in increased expression of COL4A1 mRNA	23656298
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]	11798618
C044946	benazepril	benazepril results in decreased expression of COL4A1 mRNA	16191423
C061004	benidipine	benidipine affects the expression of COL4A1 mRNA	15721868
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of COL4A1 mRNA	26377693
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL4A1 mRNA	18164116
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of COL4A1 mRNA	26001963
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of COL4A1 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of COL4A1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of COL4A1 mRNA	22610609
D019207	beta Carotene	beta Carotene results in decreased expression of COL4A1 mRNA	17034753
C044887	beta-methylcholine	beta-methylcholine affects the expression of COL4A1 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of COL4A1 mRNA	25181051
D002066	Busulfan	Busulfan affects the expression of COL4A1 mRNA	15941629
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of COL4A1 mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of COL4A1 mRNA	25596134
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of COL4A1 mRNA	25993096
C459604	candoxin	candoxin results in decreased expression of COL4A1 mRNA	16309724
D002185	Cannabidiol	Cannabidiol results in increased expression of COL4A1 mRNA	21542829
D002220	Carbamazepine	Carbamazepine affects the expression of COL4A1 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of COL4A1 mRNA	27339419
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of COL4A1 mRNA	25596134
D002746	Chlorpromazine	Chlorpromazine results in decreased expression of COL4A1 mRNA	25596134
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of COL4A1 mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL4A1 mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL4A1 mRNA	28133511
C059262	cidofovir	cidofovir affects the expression of COL4A1 mRNA	25596134
C039671	ciglitazone	ciglitazone results in decreased expression of COL4A1 mRNA	22193206
D002995	Clofibric Acid	Clofibric Acid affects the expression of COL4A1 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of COL4A1 mRNA	19320972
D003300	Copper	Copper results in increased expression of COL4A1 mRNA	24403277
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of COL4A1 mRNA	24690739
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of COL4A1 mRNA	15467011
C030973	cupric oxide	cupric oxide results in decreased expression of COL4A1 mRNA	22077320
D003474	Curcumin	Curcumin results in increased expression of COL4A1 mRNA	21594647
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]	18200517
D003474	Curcumin	Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]	28700904
D003474	Curcumin	Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]	28700904
D016572	Cyclosporine	Cyclosporine results in decreased expression of COL4A1 mRNA	20106945\|2559613
D016572	Cyclosporine	Cyclosporine results in decreased expression of COL4A1 mRNA	25596134
D000069439	Dasatinib	Dasatinib results in increased expression of COL4A1 mRNA	20579391
D013759	Dronabinol	Dronabinol results in increased expression of COL4A1 mRNA	21542829
D003907	Dexamethasone	Dexamethasone results in increased expression of COL4A1 mRNA	25047013
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL4A1 mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in increased expression of COL4A1 mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of COL4A1 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of COL4A1 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of COL4A1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of COL4A1 mRNA	25596134\|2739243
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of COL4A1 mRNA	23625948
D004041	Dietary Fats	Dietary Fats results in increased expression of COL4A1 mRNA	22609946\|2382154
D004041	Dietary Fats	RALBP1 protein affects the reaction [Dietary Fats results in increased expression of COL4A1 mRNA]	23821548
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of COL4A1 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL4A1 mRNA	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of COL4A1 mRNA	19638242
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of COL4A1 mRNA	23197195
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of COL4A1 mRNA	25380136
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of COL4A1 mRNA	22193206
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of COL4A1 mRNA	24690739
D004237	Diuron	Diuron results in increased expression of COL4A1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased expression of COL4A1 mRNA	15033991
D004656	Enalapril	Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D004656	Enalapril	Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]	9175058
D004656	Enalapril	Enalapril results in decreased expression of COL4A1 mRNA	18682491
D004656	Enalapril	Enalapril results in decreased expression of COL4A1 protein	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA	18682491
D004656	Enalapril	[eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein	18682491
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of COL4A1 mRNA	16084531
C414690	eplerenone	[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
C414690	eplerenone	[eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA	18682491
C414690	eplerenone	[eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein	18682491
C414690	eplerenone	eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
C414690	eplerenone	eplerenone results in decreased expression of COL4A1 mRNA	18682491
C414690	eplerenone	eplerenone results in decreased expression of COL4A1 protein	18682491
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of COL4A1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of COL4A1 mRNA	14976129\|1794274
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL4A1 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of COL4A1 mRNA	23300682
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of COL4A1 gene	16724327
D005047	Etoposide	Etoposide results in decreased expression of COL4A1 mRNA	25270620
D011345	Fenofibrate	Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]	28871336
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL4A1 mRNA	20938992
C079574	FR 139317	FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]	9175058
C039281	furan	furan results in increased expression of COL4A1 mRNA	26194646\|2738771
D005897	Glafenine	Glafenine results in increased expression of COL4A1 mRNA	24136188
D005947	Glucose	Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]	18682491
D005947	Glucose	Curcumin analog inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]	28700904
D005947	Glucose	Curcumin inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]	28700904
D005947	Glucose	Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D005947	Glucose	[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D005947	Glucose	eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]	18682491
D005947	Glucose	Glucose results in increased expression of COL4A1 mRNA	18682491\|2870090
D006118	Griseofulvin	Griseofulvin affects the expression of COL4A1 mRNA	12735108
C031927	hydroquinone	hydroquinone results in decreased expression of COL4A1 mRNA	18055817
C031927	hydroquinone	hydroquinone results in increased expression of COL4A1 protein	18055817
C031927	hydroquinone	MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
C031927	hydroquinone	[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
C031927	hydroquinone	TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]	18055817
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL4A1 mRNA	16054899
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of COL4A1 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of COL4A1 mRNA	27392435
D048628	Ketolides	Ketolides analog results in decreased expression of COL4A1 mRNA	24967691
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of COL4A1 mRNA	16807920
C008261	lead acetate	lead acetate results in decreased expression of COL4A1 mRNA	11578147
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of COL4A1 mRNA	27339419
D019808	Losartan	Losartan results in decreased expression of COL4A1 mRNA	16191423
C013592	mangiferin	mangiferin inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA]	19706694
D008701	Methapyrilene	Methapyrilene results in increased expression of COL4A1 mRNA	28935588
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL4A1 mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL4A1 mRNA	28133511
D008775	Methylprednisolone	Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]	1762292
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of COL4A1 mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of COL4A1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of COL4A1 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of COL4A1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of COL4A1 mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of COL4A1 mRNA	19812364
D009532	Nickel	Nickel results in increased expression of COL4A1 mRNA	24768652\|2558310
C029938	nickel sulfate	nickel sulfate results in decreased expression of COL4A1 mRNA	22714537
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of COL4A1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of COL4A1 mRNA	25729387
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of COL4A1 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of COL4A1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of COL4A1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of COL4A1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of COL4A1 mRNA]	17655762
D010100	Oxygen	Oxygen deficiency results in decreased expression of COL4A1 mRNA	25596134
D017239	Paclitaxel	Paclitaxel results in increased expression of COL4A1 mRNA	19682730
C016030	pantogab	pantogab results in increased expression of COL4A1 mRNA	17379144
D010269	Paraquat	Paraquat results in increased expression of COL4A1 mRNA	27375216\|2927341
D010269	Paraquat	pirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]	29273418
D010269	Paraquat	thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]	27375216
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of COL4A1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of COL4A1 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of COL4A1 mRNA]	17655762
C410127	PCB 180	PCB 180 results in increased expression of COL4A1 mRNA	23829299
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of COL4A1 mRNA	28511854
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL4A1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of COL4A1 mRNA	26272509
C093844	pirfenidone	pirfenidone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]	29273418
C006253	pirinixic acid	pirinixic acid results in increased expression of COL4A1 mRNA	18445702\|2081375
D010936	Plant Extracts	Plant Extracts inhibits the reaction [AGT protein results in increased expression of COL4A1 mRNA]	19706694
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of COL4A1 mRNA	22714537
D011374	Progesterone	Progesterone results in decreased expression of COL4A1 mRNA	18070364
D011374	Progesterone	Progesterone results in increased expression of COL4A1 mRNA	20864642
D011692	Puromycin Aminonucleoside	Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]	9175058
D011692	Puromycin Aminonucleoside	FR 139317 inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]	9175058
D011692	Puromycin Aminonucleoside	Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]	1762292
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA	1762292\|9175058
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of COL4A1 mRNA	27029645
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL4A1 mRNA	16054899
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of COL4A1 mRNA"	21514415
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of COL4A1 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of COL4A1 mRNA	22431001
D019821	Simvastatin	Simvastatin results in decreased expression of COL4A1 mRNA	10412775
C017947	sodium arsenite	sodium arsenite results in decreased expression of COL4A1 mRNA	22714537
C017947	sodium arsenite	sodium arsenite results in decreased expression of COL4A1 mRNA	18812580
D012999	Soman	Soman results in increased expression of COL4A1 mRNA	19281266
D053260	Soot	Soot results in increased expression of COL4A1 mRNA	26551751
C471405	sorafenib	sorafenib inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 protein]	21360571
D013311	Streptozocin	Streptozocin results in decreased expression of COL4A1 mRNA	15496156
D013311	Streptozocin	Streptozocin results in increased expression of COL4A1 mRNA	17582205
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]	11798618
D013311	Streptozocin	Streptozocin results in increased expression of COL4A1 mRNA	11798618
D013629	Tamoxifen	Tamoxifen affects the expression of COL4A1 mRNA	17555576
D013739	Testosterone	Testosterone affects the expression of COL4A1 mRNA	20403060
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of COL4A1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL4A1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COL4A1 mRNA	15328365\|2892240
D013853	Thioacetamide	HGF protein inhibits the reaction [Thioacetamide results in increased expression of COL4A1 mRNA]	10677585
D013853	Thioacetamide	Thioacetamide results in increased expression of COL4A1 mRNA	10677585
C003466	thymoquinone	thymoquinone inhibits the reaction [Paraquat results in increased expression of COL4A1 mRNA]	27375216
C009495	titanium dioxide	titanium dioxide results in increased expression of COL4A1 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of COL4A1 mRNA	27480279
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of COL4A1 mRNA	28111298
D014050	Toluene	Toluene results in increased expression of COL4A1 mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of COL4A1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of COL4A1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of COL4A1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of COL4A1 mRNA	16604517
D014212	Tretinoin	Tretinoin results in increased expression of COL4A1 mRNA	17303670
C012589	trichostatin A	trichostatin A results in increased expression of COL4A1 mRNA	23463510
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of COL4A1 mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of COL4A1 mRNA	17982090\|1820051
D014415	Tunicamycin	Tunicamycin results in decreased expression of COL4A1 mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of COL4A1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of COL4A1 mRNA	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of COL4A1 mRNA	18930951
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of COL4A1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of COL4A1 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of COL4A1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of COL4A1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of COL4A1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of COL4A1 mRNA	23034163
C029297	vinylidene chloride	vinylidene chloride results in increased expression of COL4A1 mRNA	26682919
D002762	Cholecalciferol	Cholecalciferol results in increased expression of COL4A1 mRNA	17170073
D014810	Vitamin E	Vitamin E results in increased expression of COL4A1 mRNA	19244175
C088658	zoledronic acid	Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]	28871336
C088658	zoledronic acid	SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]	28871336
C088658	zoledronic acid	zoledronic acid results in increased expression of COL4A1 mRNA	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005201	extracellular matrix structural constituent	-	IBA	21873635
GO:0005201	extracellular matrix structural constituent	-	IMP	16107487 20818663
GO:0005515	protein binding	-	IPI	12011424
GO:0030020	extracellular matrix structural constituent conferring tensile strength	-	HDA	27068509 27559042
GO:0030023	extracellular matrix constituent conferring elasticity	-	IC	16107487
GO:0048407	platelet-derived growth factor binding	-	IDA	8900172

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001569	branching involved in blood vessel morphogenesis	-	IMP	20818663
GO:0007420	brain development	-	IMP	16107487
GO:0007528	neuromuscular junction development	-	IEA	-
GO:0030198	extracellular matrix organization	-	IBA	21873635
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0030855	epithelial cell differentiation	-	IEA	-
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	-	IEA	-
GO:0048514	blood vessel morphogenesis	-	IMP	20818663
GO:0061304	retinal blood vessel morphogenesis	-	IMP	20818663
GO:0061333	renal tubule morphogenesis	-	IMP	18160688
GO:0071230	cellular response to amino acid stimulus	-	IEA	-
GO:0071711	basement membrane organization	-	IMP	18160688 19949034 23065703

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	NAS	14718574
GO:0005576	extracellular region	-	TAS	-
GO:0005587	collagen type IV trimer	-	IBA	21873635
GO:0005587	collagen type IV trimer	-	IMP	16107487
GO:0005604	basement membrane	-	IC	23065703
GO:0005615	extracellular space	-	IBA	21873635
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0031012	extracellular matrix	-	HDA	23658023
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707 27068509 27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	ISS	22261194

KEGG ID	KEGG Term
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04974	Protein digestion and absorption
hsa05146	Amoebiasis
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474290	Collagen formation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-216083	Integrin cell surface interactions	IEA
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	IEA
R-HSA-2214320	Anchoring fibril formation	TAS
R-HSA-2243919	Crosslinking of collagen fibrils	TAS
R-HSA-3000157	Laminin interactions	IEA
R-HSA-3000157	Laminin interactions	TAS
R-HSA-3000171	Non-integrin membrane-ECM interactions	TAS
R-HSA-3000178	ECM proteoglycans	IEA
R-HSA-3000480	Scavenging by Class A Receptors	IEA
R-HSA-375165	NCAM signaling for neurite out-growth	TAS
R-HSA-419037	NCAM1 interactions	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-8948216	Collagen chain trimerization	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26351537	Genetic factors involves in intracranial aneurysms--actualities. (2015 Jul-Sep)	Mohan D	J Med Life
20301768	COL4A1-Related Disorders (1993)	Plaisier E	-
26338966	Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics. (2015 Oct 6)	Qiao J	Oncotarget
29360590	Genetic Variations of the COL4A1 Gene and Intracerebral Hemorrhage Risk: A Case-Control Study in a Chinese Han Population. (2018 Apr)	Lin S	World Neurosurg
25524550	Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals. (2015 Apr)	Horibe H	Nephrology (Carlton)