Gene: KLF17

128209
ZNF393|Zfp393
Kruppel like factor 17
protein-coding
1p34.1
Ensembl:ENSG00000171872 MIM:609602 Vega:OTTHUMG00000009664 UniprotKB:Q5JT82
NC_000001.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.186e-1 (AD)  7.899e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs751442chr1:44043879 (GRCh38.p7)A>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS20.677
BEST30.659
FCRLA0.644
OR51F10.634
STK32B0.615
ARHGEF350.611
DISC10.606
LINC001890.603
CD480.602
C16orf540.601

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADPRHL1-0.524
SPTSSB-0.494
CA7-0.492
CDS1-0.491
SCRT2-0.487
EFNA5-0.487
HCN1-0.484
RORB-0.483
FGF9-0.481
CACNA2D3-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of KLF17 mRNA17562736
D001151ArsenicArsenic affects the methylation of KLF17 gene25304211
C006780bisphenol Abisphenol A affects the methylation of KLF17 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of KLF17 mRNA25181051
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of KLF17 mRNA]19228888
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KLF17 mRNA]27941970
D004397FonofosFonofos results in increased methylation of KLF17 promoter22847954
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KLF17 mRNA26911376
C000621033napabucasinnapabucasin results in decreased expression of KLF17 mRNA25605917
D010278ParathionParathion results in increased methylation of KLF17 promoter22847954
D010634PhenobarbitalPhenobarbital affects the expression of KLF17 mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of KLF17 mRNA19136022
D010936Plant ExtractsPlant Extracts results in decreased expression of KLF17 mRNA23557933
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of KLF17 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of KLF17 mRNA19228888
C012568terbufosterbufos results in increased methylation of KLF17 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF17 mRNA24058054
C012589trichostatin Atrichostatin A results in increased expression of KLF17 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of KLF17 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KLF17 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI25416956  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0044212transcription regulatory region DNA binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal