Gene info: ID 1284

Gene: COL4A2

GENE ID: 1284

Synonyms: ICH|POREN2

Description: collagen type IV alpha 2 chain

Gene type: protein-coding

Location: 13q34

dbXrefs: Ensembl:ENSG00000134871 MIM:120090 Vega:OTTHUMG00000017344 UniprotKB:P08572

RefSeq: NG_032137.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.791e-1 (AD) 5.289e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg08702745	chr13:111138063	COL4A2	Gene body	5.850e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
COL4A1	0.952
ITGB3	0.865
COL18A1	0.833
CD93	0.824
S1PR3	0.822
ADAMTS9	0.817
LAMC1	0.817
RAB27A	0.813
SHC1	0.813
FBLIM1	0.808

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HES5	-0.338
C1orf53	-0.323
SMIM18	-0.307
DIAPH3	-0.303
CRH	-0.295
MYADML2	-0.293
ATP2C2	-0.288
ZSCAN1	-0.288
ARSF	-0.284
MYCNOS	-0.282

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of COL4A2 mRNA"	26377693
C035208	2-amino-4,6-dinitrotoluene	"2-amino-4,6-dinitrotoluene results in increased expression of COL4A2 protein"	26251320
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of COL4A2 mRNA"	25380136
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of COL4A2 mRNA"	27567155
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of COL4A2 mRNA	17034753
C041819	4-oxoretinol	4-oxoretinol results in increased expression of COL4A2 mRNA	17034753
D000082	Acetaminophen	Acetaminophen results in increased expression of COL4A2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of COL4A2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of COL4A2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of COL4A2 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of COL4A2 mRNA	19770486
C103303	alitretinoin	alitretinoin results in increased expression of COL4A2 mRNA	17034753
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of COL4A2 mRNA	16483693
C004984	apocarotenal	apocarotenal results in decreased expression of COL4A2 mRNA	17034753
D001151	Arsenic	Arsenic affects the methylation of COL4A2 gene	25304211
D001241	Aspirin	Aspirin inhibits the reaction [AGT protein modified form results in increased expression of COL4A2 mRNA]	22306536
D001280	Atrazine	Atrazine results in increased expression of COL4A2 mRNA	22378314
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of COL4A2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of COL4A2 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of COL4A2 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of COL4A2 mRNA	22610609
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of COL4A2 mRNA	22300585
D019207	beta Carotene	beta Carotene results in decreased expression of COL4A2 mRNA	17034753
C044887	beta-methylcholine	beta-methylcholine affects the expression of COL4A2 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of COL4A2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of COL4A2 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of COL4A2 mRNA	15336504
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of COL4A2 mRNA	12760830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of COL4A2 mRNA	12160620
D002220	Carbamazepine	Carbamazepine affects the expression of COL4A2 mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of COL4A2 mRNA	27339419
C019304	ciprofibrate	ciprofibrate results in increased expression of COL4A2 mRNA	12771043
D060729	Coal Ash	Coal Ash results in decreased expression of COL4A2 mRNA	19000753
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of COL4A2 mRNA	19376846
D019327	Copper Sulfate	Copper Sulfate results in increased expression of COL4A2 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA]	18200517
D016572	Cyclosporine	Cyclosporine results in decreased expression of COL4A2 mRNA	20106945\|2798913
D000069439	Dasatinib	Dasatinib results in increased expression of COL4A2 mRNA	20579391
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COL4A2 mRNA]	27941970
D003907	Dexamethasone	Dexamethasone results in increased expression of COL4A2 mRNA	22733784
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of COL4A2 mRNA	27392435
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in decreased expression of COL4A2 mRNA	20705681
D002945	Cisplatin	Cisplatin results in decreased expression of COL4A2 mRNA	27392435
D002945	Cisplatin	[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of COL4A2 mRNA	23625948
C000944	dicrotophos	dicrotophos results in increased expression of COL4A2 mRNA	28302478
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of COL4A2 mRNA	12771043
D002117	Calcitriol	Calcitriol results in decreased expression of COL4A2 mRNA	12875902
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of COL4A2 mRNA	25380136
D004237	Diuron	Diuron results in increased expression of COL4A2 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in increased expression of COL4A2 mRNA	15033991
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of COL4A2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL4A2 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of COL4A2 mRNA	23300682
D005472	Fluorouracil	COL4A2 protein affects the susceptibility to Fluorouracil	15352031
D005472	Fluorouracil	Fluorouracil results in decreased expression of COL4A2 protein	15352031
C069837	fullerene C60	fullerene C60 results in increased expression of COL4A2 mRNA	19167457
D005947	Glucose	Glucose deficiency affects the secretion of COL4A2 protein	24802182
D007213	Indomethacin	Indomethacin results in decreased expression of COL4A2 mRNA	28201806
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of COL4A2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of COL4A2 mRNA	26752646
C073601	KT 5823	KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]	21307347
C073601	KT 5823	KT 5823 results in decreased expression of COL4A2 protein	21307347
D007854	Lead	Lead results in decreased expression of COL4A2 mRNA	19921347
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of COL4A2 mRNA"	24972896
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of COL4A2 mRNA	27339419
D019808	Losartan	Losartan inhibits the reaction [AGT protein modified form results in increased expression of COL4A2 mRNA]	22306536
C059539	midostaurin	midostaurin results in increased expression of COL4A2 mRNA	20980353
D016685	Mitomycin	COL4A2 protein affects the susceptibility to Mitomycin	16217747
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of COL4A2 protein"	21135415
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of COL4A2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of COL4A2 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of COL4A2 mRNA	25380136
C028007	nickel monoxide	nickel monoxide results in increased expression of COL4A2 mRNA	19167457
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of COL4A2 mRNA	12760830
C093285	NOC 18	COL4A2 protein affects the susceptibility to NOC 18	21307347
C093285	NOC 18	COL4A2 protein promotes the reaction [NOC 18 results in increased phosphorylation of PTK2 protein]	21307347
C093285	NOC 18	KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]	21307347
C093285	NOC 18	NOC 18 results in increased expression of COL4A2 protein	21307347
C093285	NOC 18	PRKG1 protein promotes the reaction [NOC 18 results in increased expression of COL4A2 protein]	21307347
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of COL4A2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of COL4A2 mRNA	25729387
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in decreased expression of COL4A2 mRNA	20705681
D017239	Paclitaxel	Paclitaxel results in increased expression of COL4A2 mRNA	19682730
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of COL4A2 mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of COL4A2 protein	26178269
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of COL4A2 mRNA	28511854
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of COL4A2 mRNA	17616710
C006253	pirinixic acid	pirinixic acid results in increased expression of COL4A2 mRNA	23811191
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of COL4A2 mRNA	22714537
D015474	Isotretinoin	Isotretinoin results in increased expression of COL4A2 mRNA	20436886
D012834	Silver	Silver results in increased expression of COL4A2 mRNA	26014281
C017947	sodium arsenite	sodium arsenite results in decreased expression of COL4A2 mRNA	22714537
C016104	sodium bichromate	sodium bichromate results in decreased expression of COL4A2 mRNA	12760830
C004648	testosterone enanthate	testosterone enanthate affects the expression of COL4A2 mRNA	17440010
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of COL4A2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL4A2 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of COL4A2 mRNA	24035824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COL4A2 mRNA	28922406
C009495	titanium dioxide	titanium dioxide results in decreased expression of COL4A2 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of COL4A2 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of COL4A2 mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of COL4A2 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of COL4A2 mRNA	12875902\|2372400
D014212	Tretinoin	Tretinoin results in increased expression of COL4A2 mRNA	17034753
D014212	Tretinoin	Tretinoin results in increased expression of COL4A2 mRNA	16604517
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of COL4A2 mRNA	19042947
D014302	Trinitrobenzenesulfonic Acid	Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA]	18200517
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of COL4A2 mRNA	18200517
C057693	troglitazone	troglitazone results in decreased expression of COL4A2 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in decreased expression of COL4A2 mRNA	28001369\|2915479
D014635	Valproic Acid	Valproic Acid results in increased methylation of COL4A2 gene	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of COL4A2 mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased expression of COL4A2 mRNA	23034163
D014801	Vitamin A	Vitamin A results in increased expression of COL4A2 mRNA	17034753

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005201	extracellular matrix structural constituent	-	IBA	21873635
GO:0005201	extracellular matrix structural constituent	-	TAS	8317999
GO:0005515	protein binding	-	IPI	12011424
GO:0030020	extracellular matrix structural constituent conferring tensile strength	-	HDA	20551380 27068509 27559042
GO:0030020	extracellular matrix structural constituent conferring tensile strength	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001525	angiogenesis	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0014823	response to activity	-	IEA	-
GO:0016525	negative regulation of angiogenesis	-	IDA	10625665
GO:0030198	extracellular matrix organization	-	IBA	21873635
GO:0030198	extracellular matrix organization	-	NAS	8317999
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0035987	endodermal cell differentiation	-	IEP	23154389
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	-	IBA	21873635
GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	-	IEA	-
GO:0071560	cellular response to transforming growth factor beta stimulus	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005587	collagen type IV trimer	-	IBA	21873635
GO:0005587	collagen type IV trimer	-	TAS	2846280 3345760
GO:0005615	extracellular space	-	IBA	21873635
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0031012	extracellular matrix	-	HDA	23658023
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707 27068509 27559042
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	ISS	22261194
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	TAS	22261194
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa04974	Protein digestion and absorption
hsa05146	Amoebiasis
hsa05200	Pathways in cancer
hsa05222	Small cell lung cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474290	Collagen formation	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-216083	Integrin cell surface interactions	IEA
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	IEA
R-HSA-2214320	Anchoring fibril formation	TAS
R-HSA-2243919	Crosslinking of collagen fibrils	TAS
R-HSA-3000157	Laminin interactions	IEA
R-HSA-3000157	Laminin interactions	TAS
R-HSA-3000171	Non-integrin membrane-ECM interactions	TAS
R-HSA-3000178	ECM proteoglycans	IEA
R-HSA-3000480	Scavenging by Class A Receptors	IEA
R-HSA-375165	NCAM signaling for neurite out-growth	TAS
R-HSA-419037	NCAM1 interactions	TAS
R-HSA-422475	Axon guidance	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-8948216	Collagen chain trimerization	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26670299	Genetic risk factors for spontaneous intracerebral haemorrhage. (2016 Jan)	Carpenter AM	Nat Rev Neurol