Gene: TSHZ2

128553
C20orf17|OVC10-2|TSH2|ZABC2|ZNF218
teashirt zinc finger homeobox 2
protein-coding
20q13.2
Ensembl:ENSG00000182463 MIM:614118 Vega:OTTHUMG00000033058 UniprotKB:Q9NRE2
NG_053184.1
PubMed|SNP Mapped
5   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.575e-1 (AD)  6.964e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1996017chr20:53306099 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6022378chr20:53300709 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs1543080chr20:53280576 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4356720chr20:53055771 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs910380chr20:53032939 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRMP0.847
FOXP20.838
ACVR2A0.821
CLSTN20.807
PCLO0.799
TTC39C0.797
ERC20.795
CAMK2D0.792
IL1RAPL20.788
POU6F20.786

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.454
MSX1-0.44
RARRES2-0.44
LCAT-0.431
ASB4-0.43
S100A1-0.429
HEY2-0.422
CYP11A1-0.42
ACOX2-0.418
RHOD-0.413

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TSHZ2 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TSHZ2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TSHZ2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TSHZ2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TSHZ2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TSHZ2 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of TSHZ2 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TSHZ2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TSHZ2 mRNA19770486
D000968Antimycin AAntimycin A results in decreased expression of TSHZ2 mRNA19304788
D001104ArbutinArbutin results in decreased expression of TSHZ2 mRNA17103032
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TSHZ2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TSHZ2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TSHZ2 mRNA19770486|2171566
C044887beta-methylcholinebeta-methylcholine affects the expression of TSHZ2 mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of TSHZ2 promoter27334623
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TSHZ2 mRNA20147733
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TSHZ2 mRNA17484886
D003907DexamethasoneDexamethasone results in decreased expression of TSHZ2 mRNA25047013
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TSHZ2 mRNA24535843
C118739entinostatentinostat results in decreased expression of TSHZ2 mRNA26272509
C118739entinostatentinostat results in increased expression of TSHZ2 mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
D007854LeadLead results in increased expression of TSHZ2 mRNA19921347
D008345ManganeseManganese results in increased expression of TSHZ2 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of TSHZ2 mRNA17175027
D008727MethotrexateMethotrexate results in increased expression of TSHZ2 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TSHZ2 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TSHZ2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TSHZ2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TSHZ2 mRNA"25554681
D010100OxygenOxygen deficiency results in increased expression of TSHZ2 mRNA17175027
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TSHZ2 mRNA"25510870
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TSHZ2 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of TSHZ2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of TSHZ2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of TSHZ2 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSHZ2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TSHZ2 mRNA26272509
D012402RotenoneRotenone results in decreased expression of TSHZ2 mRNA19304788
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of TSHZ2 mRNA15601916
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSHZ2 mRNA24058054
D014212TretinoinTretinoin results in increased expression of TSHZ2 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of TSHZ2 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of TSHZ2 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of TSHZ2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TSHZ2 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased methylation of TSHZ2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TSHZ2 mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of TSHZ2 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0003682chromatin binding-IBA21873635  
GO:0005515protein binding-IPI24407287  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0007275multicellular organism development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26333835Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration. (2015 Dec)Scheinfeldt LBAm J Med Genet B Neuropsychiatr Genet