Gene: SIRPD

128646
PTPNS1L2|dJ576H24.4
signal regulatory protein delta
protein-coding
20p13
Ensembl:ENSG00000125900 Vega:OTTHUMG00000031674 UniprotKB:Q9H106
NC_000020.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.079e-1 (AD)  5.564e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2249431chr20:1552559 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR80.631
CD1D0.626
SIRPB20.597
ARL110.59
SNX200.582
RAB380.581
CD300LF0.569
VENTX0.564
FPR20.564
LILRA60.564

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.362
KIF21B-0.3
ARSF-0.295
WFDC1-0.295
FRMPD1-0.29
CYP1A1-0.288
WNT7A-0.287
ST6GAL2-0.283
KIT-0.28
CRH-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SIRPD mRNA"23146750
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SIRPD mRNA23649840
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SIRPD mRNA23649840
C005556propionaldehydepropionaldehyde results in decreased expression of SIRPD mRNA26079696
C016766sulforafansulforafan results in increased expression of SIRPD mRNA26833863
D014635Valproic AcidValproic Acid results in increased methylation of SIRPD gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal