Gene: PROKR2

128674
GPR73L1|GPR73b|GPRg2|HH3|KAL3|PKR2|dJ680N4.3
prokineticin receptor 2
protein-coding
20p12.3
Ensembl:ENSG00000101292 MIM:607123 Vega:OTTHUMG00000031800 UniprotKB:Q8NFJ6
NG_008132.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.285e-1 (AD)  1.985e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL1RAPL20.857
IL12RB20.837
PCDHA50.81
CLSTN20.807
PLCXD20.806
PPM1E0.802
PCDHAC20.798
GRIN3A0.794
GABRG30.794
CDH70.784

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.554
STON2-0.55
RAB13-0.539
GNG5-0.531
TRIP6-0.53
HIST1H1C-0.528
CHST14-0.52
IMPA2-0.514
RNF135-0.514
ACAA2-0.513

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PROKR2 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PROKR2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PROKR2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PROKR2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PROKR2 mRNA"25510870
D020106AcrylamideAcrylamide results in decreased expression of PROKR2 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PROKR2 mRNA16483693
C015001arsenitearsenite results in increased methylation of PROKR2 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of PROKR2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PROKR2 mRNA27257137
D002211CapsaicinCapsaicin results in decreased expression of PROKR2 mRNA16278290
D003471CuprizoneCuprizone results in decreased expression of PROKR2 mRNA26577399
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PROKR2 mRNA23914054
D003976DiazinonDiazinon results in increased methylation of PROKR2 gene22964155
C008261lead acetatelead acetate results in decreased expression of PROKR2 mRNA22641619
C045463leflunomideleflunomide results in decreased expression of PROKR2 mRNA19751817
D008694MethamphetaminePROKR2 gene SNP affects the susceptibility to Methamphetamine20576534
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PROKR2 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of PROKR2 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of PROKR2 mRNA24780913
D018038Sodium SeleniteSodium Selenite results in decreased expression of PROKR2 mRNA18175754
D014635Valproic AcidValproic Acid results in increased methylation of PROKR2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001602pancreatic polypeptide receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007623circadian rhythm-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA18826963  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21224062Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. (2011 Jan)Shaw JLAm J Pathol