Gene: COL6A3

1293
BTHLM1|DYT27|UCMD1
collagen type VI alpha 3 chain
protein-coding
2q37.3
Ensembl:ENSG00000163359 MIM:120250 Vega:OTTHUMG00000150020 UniprotKB:P12111
NG_008676.1
PubMed
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.027e-1 (AD)  4.099e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL3A10.857
COL8A10.788
COL1A10.771
MGP0.76
COL1A20.734
COL14A10.716
GPX80.699
MMP20.696
PLN0.691
FBLIM10.686

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DBP-0.409
ZNF835-0.4
NEUROD6-0.385
ASPDH-0.378
MYADML2-0.375
RNFT2-0.37
TM7SF2-0.363
CHRNA4-0.363
TMEM221-0.362
CCDC24-0.361

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"[1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"[Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of COL6A3 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of COL6A3 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of COL6A3 mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of COL6A3 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of COL6A3 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of COL6A3 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of COL6A3 mRNA"25510870
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene results in decreased expression of COL6A3 mRNA"26251320
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of COL6A3 mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of COL6A3 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of COL6A3 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of COL6A3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of COL6A3 gene27153756
D001151ArsenicArsenic affects the methylation of COL6A3 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of COL6A3 mRNA20458559
D001374AzacitidineAzacitidine results in decreased expression of COL6A3 mRNA20823114
C547126AZM551248AZM551248 results in increased expression of COL6A3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL6A3 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL6A3 mRNA22300585
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of COL6A3 mRNA20823114
D004958EstradiolEstradiol affects the expression of COL6A3 protein20864640
D004958EstradiolEstradiol results in increased expression of COL6A3 mRNA15289156
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of COL6A3 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of COL6A3 protein28273538
C006780bisphenol Abisphenol A results in increased expression of COL6A3 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of COL6A3 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of COL6A3 mRNA18958704
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of COL6A3 mRNA22079614
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of COL6A3 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL6A3 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of COL6A3 mRNA22300585
D016572Cyclosporine"[Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
D016572CyclosporineCyclosporine inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]18435905
D016572CyclosporineCyclosporine results in increased methylation of COL6A3 promoter27989131
D003561CytarabineCytarabine results in decreased expression of COL6A3 mRNA21198554
D003907DexamethasoneDexamethasone results in decreased expression of COL6A3 mRNA25047013
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]16054899
D003907DexamethasoneDexamethasone results in decreased expression of COL6A3 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of COL6A3 mRNA]20032058
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of COL6A3 mRNA20823114
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of COL6A3 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of COL6A3 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of COL6A3 mRNA15289156
D004237DiuronDiuron results in increased expression of COL6A3 mRNA21551480
D004317DoxorubicinCOL6A3 protein affects the susceptibility to Doxorubicin16217747
D004317DoxorubicinDoxorubicin results in increased expression of COL6A3 mRNA15033991
D004533Egtazic Acid"[1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
D004533Egtazic Acid"[Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
C118739entinostatentinostat results in increased expression of COL6A3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of COL6A3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COL6A3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL6A3 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of COL6A3 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of COL6A3 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of COL6A3 mRNA27776689
D005472FluorouracilCOL6A3 protein affects the susceptibility to Fluorouracil16217747
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of COL6A3 mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL6A3 mRNA20938992
D004397FonofosFonofos results in increased methylation of COL6A3 promoter22847954
D019833GenisteinGenistein results in increased expression of COL6A3 mRNA15289156
D017313FenretinideFenretinide results in decreased expression of COL6A3 mRNA28973697
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]16054899
D007529IsoflavonesIsoflavones affects the expression of COL6A3 mRNA16365062
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL6A3 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL6A3 mRNA26644586
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of COL6A3 mRNA20823114
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL6A3 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of COL6A3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of COL6A3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of COL6A3 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of COL6A3 mRNA16166746
D009840OligomycinsCOL6A3 gene mutant form results in increased susceptibility to Oligomycins18435905
D017239PaclitaxelCOL6A3 protein affects the susceptibility to Paclitaxel16217747
D000073878Palm OilPalm Oil results in decreased expression of COL6A3 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of COL6A3 mRNA26272509
D010278ParathionParathion results in increased methylation of COL6A3 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of COL6A3 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of COL6A3 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of COL6A3 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of COL6A3 mRNA8224229
C006253pirinixic acidpirinixic acid results in decreased expression of COL6A3 mRNA17426115
D011192Potassium DichromatePotassium Dichromate results in increased expression of COL6A3 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of COL6A3 mRNA23012394
D011374ProgesteroneProgesterone affects the expression of COL6A3 protein20864640
D011794QuercetinQuercetin results in increased expression of COL6A3 mRNA16455785
C059514resveratrolresveratrol results in decreased expression of COL6A3 mRNA19228061
D015474IsotretinoinIsotretinoin results in increased expression of COL6A3 mRNA20436886
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]16054899
D012402Rotenone"[1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
D012402Rotenone"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
D012402RotenoneCOL6A3 gene mutant form results in increased susceptibility to Rotenone18435905
D012402Rotenone"[Cyclosporine co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Egtazic Acid] inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]"18435905
D012402RotenoneCyclosporine inhibits the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]18435905
D012402RotenoneThapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]18435905
C017947sodium arsenitesodium arsenite results in decreased expression of COL6A3 mRNA18812580
D012999SomanSoman results in increased expression of COL6A3 mRNA19281266
D013311StreptozocinStreptozocin results in increased expression of COL6A3 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of COL6A3 protein]19634143
D013467SulindacSulindac results in increased expression of COL6A3 mRNA18499699
D014284TriiodothyronineTriiodothyronine results in increased expression of COL6A3 mRNA15507505
D013629TamoxifenTamoxifen affects the expression of COL6A3 mRNA14699072
D013629TamoxifenTamoxifen affects the expression of COL6A3 mRNA17555576
C012568terbufosterbufos results in increased methylation of COL6A3 promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of COL6A3 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL6A3 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL6A3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of COL6A3 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of COL6A3 mRNA]15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL6A3 mRNA16922920|1993321
D019284ThapsigarginThapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone]18435905
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COL6A3 mRNA28111298
C011559tributyltintributyltin results in increased expression of COL6A3 mRNA21683754
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of COL6A3 mRNA26272509
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of COL6A3 protein]19634143
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL6A3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of COL6A3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of COL6A3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of COL6A3 mRNA24896083
D014640VancomycinVancomycin results in decreased expression of COL6A3 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of COL6A3 gene25560391
C025643vinclozolinvinclozolin affects the expression of COL6A3 mRNA19015723
D014810Vitamin EVitamin E results in increased expression of COL6A3 mRNA19244175
C111237vorinostatvorinostat results in increased expression of COL6A3 mRNA26272509
D019287Zinc SulfateZinc Sulfate results in decreased expression of COL6A3 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0030020extracellular matrix structural constituent conferring tensile strength-HDA20551380  27559042  
GO:0030020extracellular matrix structural constituent conferring tensile strength-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003429growth plate cartilage chondrocyte morphogenesis-IBA21873635  
GO:0007155cell adhesion-IEA-  
GO:0007517muscle organ development-TAS8782832  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005589collagen type VI trimer-TAS8782832  
GO:0005615extracellular space-HDA20551380  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-HDA23658023  
GO:0031012extracellular matrix-IDA18400749  
GO:0042383sarcolemma-IEA-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474290Collagen formationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000178ECM proteoglycansTAS
R-HSA-3000178ECM proteoglycansIEA
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-419037NCAM1 interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8948216Collagen chain trimerizationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26338966Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics. (2015 Oct 6)Qiao JOncotarget
28226201Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. (2017 May)Adkins AEAlcohol Clin Exp Res
24002763Clinical significance of serum COL6A3 in pancreatic ductal adenocarcinoma. (2014 Jan)Kang CYJ Gastrointest Surg