Gene: COL8A1

1295
C3orf7
collagen type VIII alpha 1 chain
protein-coding
3q12.1
Ensembl:ENSG00000144810 MIM:120251 Vega:OTTHUMG00000148669 UniprotKB:P27658
NC_000003.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.062e-1 (AD)  7.706e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OGN0.899
COL14A10.882
BMX0.868
GJA50.867
PLN0.867
COL3A10.864
MGP0.856
TRABD2B0.855
TBX180.849
SLC16A120.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.502
DBP-0.427
HAGHL-0.426
ZNF835-0.401
FAM43B-0.399
BAIAP2L2-0.392
C9orf24-0.391
CHRNA4-0.39
C15orf59-0.387
NAT14-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of COL8A1 mRNA19933214
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of COL8A1 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL8A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL8A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL8A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL8A1 mRNA"27188386
C496492abrineabrine results in increased expression of COL8A1 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of COL8A1 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of COL8A1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of COL8A1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of COL8A1 mRNA21298039
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of COL8A1 mRNA"22863853
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of COL8A1 mRNA15894712
C015001arsenitearsenite results in decreased expression of COL8A1 mRNA15894712
C547126AZM551248AZM551248 results in increased expression of COL8A1 mRNA22323515
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of COL8A1 mRNA]15034205
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of COL8A1 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL8A1 mRNA15034205|1589471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COL8A1 mRNA27195522
D004958EstradiolEstradiol results in increased expression of COL8A1 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of COL8A1 mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of COL8A1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of COL8A1 mRNA18560533
D019256Cadmium ChlorideCadmium Chloride results in increased expression of COL8A1 mRNA12160620
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL8A1 mRNA19840844
D002122Calcium ChlorideCalcium Chloride results in increased expression of COL8A1 protein25824407
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of COL8A1 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL8A1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of COL8A1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of COL8A1 mRNA20599845
D019327Copper SulfateCopper Sulfate results in increased expression of COL8A1 mRNA20599845
D003471CuprizoneCuprizone results in increased expression of COL8A1 mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of COL8A1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of COL8A1 mRNA22733784
D003976DiazinonDiazinon results in decreased expression of COL8A1 mRNA29108742
D004026DieldrinDieldrin results in increased expression of COL8A1 mRNA20438755
D004041Dietary FatsDietary Fats results in increased expression of COL8A1 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of COL8A1 mRNA26485663
D004317DoxorubicinDoxorubicin results in increased expression of COL8A1 mRNA15033991
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COL8A1 mRNA17942748
C540355fenamidonefenamidone results in increased expression of COL8A1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL8A1 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of COL8A1 mRNA19167457
C039281furanfuran results in increased expression of COL8A1 mRNA27387713
C001277geldanamycingeldanamycin results in increased expression of COL8A1 mRNA26705709
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of COL8A1 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of COL8A1 mRNA17109745
D005944GlucosamineIL1B inhibits the reaction [Glucosamine results in decreased expression of COL8A1 mRNA]17109745
D017313FenretinideFenretinide results in decreased expression of COL8A1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of COL8A1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of COL8A1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL8A1 mRNA24796395
C008261lead acetatelead acetate results in decreased expression of COL8A1 mRNA11578147|2264161
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of COL8A1 mRNA21641980
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL8A1 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of COL8A1 mRNA20938992
D008727MethotrexateMethotrexate affects the expression of COL8A1 mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of COL8A1 mRNA20713471
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of COL8A1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL8A1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL8A1 mRNA19840844
D009151Mustard GasMustard Gas results in decreased expression of COL8A1 mRNA25102026
D009532NickelNickel results in decreased expression of COL8A1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of COL8A1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of COL8A1 mRNA22714537
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of COL8A1 mRNA19840844
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of COL8A1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of COL8A1 mRNA24205000
D000073878Palm OilPalm Oil results in increased expression of COL8A1 mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of COL8A1 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL8A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of COL8A1 mRNA26272509
D009764o-Phthalaldehydeo-Phthalaldehyde affects the expression of COL8A1 mRNA22302311
D010936Plant ExtractsPlant Extracts results in decreased expression of COL8A1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of COL8A1 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of COL8A1 mRNA23608068
D011205Povidone[Silver analog co-treated with Povidone] results in increased expression of COL8A1 mRNA25194297
D011374ProgesteroneProgesterone results in decreased expression of COL8A1 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in decreased expression of COL8A1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of COL8A1 mRNA27029645
C052785rebamipiderebamipide results in decreased expression of COL8A1 mRNA15104358
D012834Silver[Silver analog co-treated with Povidone] results in increased expression of COL8A1 mRNA25194297
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of COL8A1 mRNA21641980
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of COL8A1 mRNA]14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COL8A1 mRNA15034205|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL8A1 mRNA14728982
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of COL8A1 mRNA19840844
C009495titanium dioxidetitanium dioxide results in increased expression of COL8A1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of COL8A1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of COL8A1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of COL8A1 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of COL8A1 mRNA"19682533
C015559trimellitic anhydridetrimellitic anhydride affects the expression of COL8A1 mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of COL8A1 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of COL8A1 mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of COL8A1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of COL8A1 gene29154799
D014640VancomycinVancomycin results in decreased expression of COL8A1 mRNA18930951
D015032ZincZinc deficiency results in decreased expression of COL8A1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0005515protein binding-IPI16189514  25416956  
GO:0030020extracellular matrix structural constituent conferring tensile strength-HDA20551380  27068509  27559042  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0048593camera-type eye morphogenesis-IEA-  
GO:0050673epithelial cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005591collagen type VIII trimer-TAS2029894  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA23979707  27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1442490Collagen degradationIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet
29487693Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants. (2018 Jan 30)Cascella ROncotarget
25655794Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. (2015 Apr)Seddon JMInvest Ophthalmol Vis Sci