Gene: TMEM18

129787
lncND
transmembrane protein 18
protein-coding
2p25.3
Ensembl:ENSG00000151353 MIM:613220 Vega:OTTHUMG00000151381 UniprotKB:Q96B42
NC_000002.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.922e-2 (AD)  7.650e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PWP10.889
LIAS0.888
COA10.885
NAE10.884
ANKRA20.884
SRP190.882
ASH2L0.881
RPAIN0.88
ACBD60.88
PSMA50.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.53
OR4F29-0.508
MTRNR2L6-0.48
MTRNR2L9-0.461
MTRNR2L10-0.419
MTRNR2L2-0.367
MTRNR2L8-0.366
EVC2-0.352
TTLL10-0.336
SERPINH1-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TMEM18 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C006632arsenic trioxidearsenic trioxide results in decreased expression of TMEM18 mRNA26705709
D001280AtrazineAtrazine results in increased expression of TMEM18 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of TMEM18 mRNA21786754
C018475butyraldehydebutyraldehyde results in decreased expression of TMEM18 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of TMEM18 mRNA25979313
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TMEM18 mRNA15467011
D016572CyclosporineCyclosporine results in increased expression of TMEM18 mRNA25562108|2798913
C014347decitabinedecitabine results in decreased expression of TMEM18 mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of TMEM18 mRNA]19363521
D005485FlutamideFlutamide results in increased expression of TMEM18 mRNA21126777
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TMEM18 mRNA25613284
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of TMEM18 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of TMEM18 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMEM18 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TMEM18 mRNA"20188158
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of TMEM18 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TMEM18 mRNA26272509
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of TMEM18 mRNA19564919
C534628SCH 23390SCH 23390 results in decreased expression of TMEM18 mRNA19564919
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of TMEM18 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TMEM18 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of TMEM18 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TMEM18 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of TMEM18 mRNA28542535
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM18 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TMEM18 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMEM18 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of TMEM18 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMEM18 gene25560391
D010205Pantothenic AcidPantothenic Acid results in increased expression of TMEM18 mRNA19397697
D024483Vitamin K 3Vitamin K 3 affects the expression of TMEM18 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0016477cell migration-IDA18559506  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0031965nuclear membrane-IDA18559506  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes
23311614Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. (2013 Jan 11)Fesinmeyer MDBMC Med Genet
28957450Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium. (2017)Wang TPLoS One