Gene: ADH6

130
ADH-5
AD dehydrogenase 6 (class V)
protein-coding
4q23
Ensembl:ENSG00000172955 MIM:103735 Vega:OTTHUMG00000131024 UniprotKB:P28332
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.359e-1 (AD)  4.657e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPH10.499
SLC35A30.497
CD1090.495
RGS220.489
MCOLN20.48
UEVLD0.47
ANKUB10.467
CD1600.467
AASS0.467
ABCA10.466

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.39
MAGIX-0.362
C16orf95-0.339
SAC3D1-0.332
FAM57B-0.332
FAM43B-0.326
FIZ1-0.32
PHOSPHO1-0.319
NPAS1-0.319
FAM71E1-0.318

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
DB01048AbacavirSmall Molecule136470-78-5Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ADH6 mRNA"17547211
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6]27055685
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA]27055685
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADH6 mRNA"27055685
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ADH6 mRNA"21346803
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of ADH6 mRNA"26238291
D000082AcetaminophenAcetaminophen results in decreased expression of ADH6 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ADH6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADH6 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADH6 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ADH6 mRNA21757418
D000447AldehydesAldehydes results in decreased expression of ADH6 mRNA25014914
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADH6 mRNA20106945|2163298
D004958EstradiolEstradiol results in decreased expression of ADH6 mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of ADH6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADH6 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of ADH6 mRNA26079696
D002104CadmiumCadmium results in decreased expression of ADH6 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADH6 mRNA17547211
D019327Copper SulfateCopper Sulfate results in decreased expression of ADH6 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ADH6 mRNA20106945|2163298
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADH6 mRNA21527772
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ADH6 mRNA17547211
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH6 mRNA26159488
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ADH6 mRNA24534155
C045463leflunomideleflunomide results in decreased expression of ADH6 mRNA28988120
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ADH6 mRNA27055685
C500085muraglitazarmuraglitazar results in increased expression of ADH6 mRNA21515302
C010463n-hexanaln-hexanal affects the expression of ADH6 mRNA26880647
C046012pentanalpentanal results in decreased expression of ADH6 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ADH6 mRNA28511854
D010634PhenobarbitalPhenobarbital results in decreased expression of ADH6 mRNA19084549
C005556propionaldehydepropionaldehyde results in decreased expression of ADH6 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ADH6 mRNA21632981
C089730rosiglitazonerosiglitazone results in decreased expression of ADH6 mRNA25572481
C089730rosiglitazonerosiglitazone results in increased expression of ADH6 mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADH6 mRNA25895662
C501413tesaglitazartesaglitazar results in increased expression of ADH6 mRNA21515302
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6]27055685
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA]27055685
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA]27055685
D013749TetrachlorodibenzodioxinARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA]27055685
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ADH6 mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADH6 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH6 mRNA20106945|2163298
D013853ThioacetamideThioacetamide results in increased expression of ADH6 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ADH6 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ADH6 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ADH6 mRNA29154799
C574123walrycin Awalrycin A results in decreased expression of ADH6 mRNA22314385
D015032ZincZinc deficiency results in increased expression of ADH6 mRNA18356318
C088658zoledronic acidzoledronic acid results in decreased expression of ADH6 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004022alcohol dehydrogenase (NAD) activity-IDA1755855  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-EXP9982  
GO:0008270zinc ion binding-NAS1593644  
GO ID GO Term Qualifier Evidence PubMed
GO:0006069ethanol oxidation-IDA1755855  
GO:0006069ethanol oxidation-TAS-  
GO:0045471response to ethanol-IDA1755855  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
23468174Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)Zuo LHum Genet
22690706Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain). (2012 Dec)Munoz XAddiction
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
17185388Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (2007 Feb 15)Luo XHum Mol Genet
23456092Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)Park BLHum Genet
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res