Gene: COL11A2

1302
DFNA13|DFNB53|FBCG2|HKE5|OSMEDA|OSMEDB|PARP|STL3
collagen type XI alpha 2 chain
protein-coding
6p21.32
Ensembl:ENSG00000204248 MIM:120290 Vega:OTTHUMG00000031036 UniprotKB:P13942
NG_011589.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF2760.837
CES4A0.832
SCNN1D0.829
ADAMTS130.813
LAS1L0.808
UCKL10.795
FBF10.792
MAPKBP10.79
ZNF1350.788
JAKMIP30.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTRNR2L10-0.406
MTRNR2L9-0.398
FCGR3B-0.387
MTRNR2L6-0.386
TRDN-0.369
ELF5-0.359
GJB2-0.359
H3F3C-0.358
HBD-0.353
KCNJ15-0.353

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of COL11A2 mRNA"25614096
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of COL11A2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of COL11A2 mRNA28959563
D001151ArsenicArsenic affects the methylation of COL11A2 gene25304211
C547126AZM551248AZM551248 results in decreased expression of COL11A2 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of COL11A2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of COL11A2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of COL11A2 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of COL11A2 promoter22457795
D019327Copper SulfateCopper Sulfate results in increased expression of COL11A2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of COL11A2 mRNA26577399|2752363
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of COL11A2 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of COL11A2 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] affects the expression of COL11A2 mRNA20705681
D002945CisplatinCOL11A2 protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of COL11A2 mRNA18042831
D019422Dietary SucroseDietary Sucrose results in increased expression of COL11A2 mRNA26033743
D004237DiuronDiuron results in decreased expression of COL11A2 mRNA21551480
C118739entinostatentinostat results in increased expression of COL11A2 mRNA27188386
D007213IndomethacinIndomethacin results in increased expression of COL11A2 mRNA28201806
C008261lead acetatelead acetate affects the expression of COL11A2 mRNA21147602
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] affects the expression of COL11A2 mRNA20705681
D000073878Palm OilPalm Oil results in increased expression of COL11A2 mRNA18042831
D011441PropylthiouracilPropylthiouracil results in decreased expression of COL11A2 mRNA24780913
C009277sodium arsenatesodium arsenate results in increased expression of COL11A2 mRNA23922661
D053260SootSoot results in increased expression of COL11A2 mRNA26551751
C061133tamibarotenetamibarotene affects the expression of COL11A2 mRNA15498508
D013629TamoxifenTamoxifen results in increased expression of COL11A2 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL11A2 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of COL11A2 mRNA15498508
D014212Tretinoin[Tretinoin binds to RXRB protein] which binds to COL11A2 enhancer15206905
D014212TretinoinTretinoin results in increased expression of COL11A2 mRNA15206905
C012589trichostatin Atrichostatin A results in decreased expression of COL11A2 mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of COL11A2 mRNA24935251|2627250
D014635Valproic AcidValproic Acid results in decreased expression of COL11A2 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of COL11A2 mRNA23179753|2438349
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL11A2 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0005515protein binding-IPI17703188  
GO:0030020extracellular matrix structural constituent conferring tensile strength-NAS7859284  8838804  
GO:0030674protein binding, bridging-NAS10677296  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IMP10677296  
GO:0001501skeletal system development-NAS7859284  8838804  
GO:0007605sensory perception of sound-IBA21873635  
GO:0007605sensory perception of sound-IMP9188673  10581026  10677296  16033917  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030199collagen fibril organization-IBA21873635  
GO:0030199collagen fibril organization-IDA9188673  
GO:0051216cartilage development-IBA21873635  
GO:0051216cartilage development-IMP9188673  
GO:0060021roof of mouth development-IMP12673280  
GO:0060023soft palate development-IMP10677296  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IBA21873635  
GO:0005592collagen type XI trimer-NAS7859284  8838804  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04974Protein digestion and absorption
hsa05146Amoebiasis
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationIEA
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-6806834Signaling by METTAS
R-HSA-8874081MET activates PTK2 signalingTAS
R-HSA-8875878MET promotes cell motilityTAS
R-HSA-8948216Collagen chain trimerizationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28300138Reduced DNA methylation and psychopathology following endogenous hypercortisolism - a genome-wide study. (2017 Mar 16)Glad CASci Rep