Gene: SGPP2

130367
SPP2|SPPase2
sphingosine-1-phosphate phosphatase 2
protein-coding
2q36.1
Ensembl:ENSG00000163082 MIM:612827 Vega:OTTHUMG00000133156 UniprotKB:Q8IWX5
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.255e-1 (AD)  9.105e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MKL20.894
MEF2A0.84
UBE4A0.838
SMCR80.836
SLC12A60.83
M6PR0.83
FBXO110.825
GPATCH80.823
MTPN0.821
SMAP10.821

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.46
BCL7C-0.425
RARRES2-0.401
RBP1-0.4
ASCL1-0.398
TSC22D4-0.386
HMX1-0.383
NEU4-0.379
PON1-0.378
NKX2-2-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SGPP2 mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SGPP2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SGPP2 mRNA21298039
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of SGPP2 gene28505145
C006780bisphenol Abisphenol A results in decreased expression of SGPP2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SGPP2 mRNA26472689
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of SGPP2 mRNA]16221973
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SGPP2 mRNA26272509
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of SGPP2 mRNA24834073
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SGPP2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SGPP2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SGPP2 mRNA27392435
C118739entinostatentinostat results in increased expression of SGPP2 mRNA27188386
D005557FormaldehydeFormaldehyde results in decreased expression of SGPP2 mRNA23649840
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of SGPP2 gene28505145
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SGPP2 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SGPP2 mRNA18192897
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of SGPP2 gene21212295
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SGPP2 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SGPP2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SGPP2 mRNA"25554681
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SGPP2 mRNA26272509
C046012pentanalpentanal results in increased expression of SGPP2 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of SGPP2 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of SGPP2 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of SGPP2 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SGPP2 mRNA25895662
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of SGPP2 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of SGPP2 gene21212295
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SGPP2 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of SGPP2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SGPP2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SGPP2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SGPP2 mRNA17963808
C088658zoledronic acidzoledronic acid results in increased expression of SGPP2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042392sphingosine-1-phosphate phosphatase activity-IDA12411432  
GO:0042392sphingosine-1-phosphate phosphatase activity-TAS-  
GO:0070780dihydrosphingosine-1-phosphate phosphatase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006670sphingosine metabolic process-IDA12411432  
GO:0016311dephosphorylation-IEA-  
GO:0030148sphingolipid biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA12411432  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00600Sphingolipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26485657Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD). (2015)Barnawi JPLoS One