Gene: COL13A1

1305
CMS19|COLXIIIA1
collagen type XIII alpha 1 chain
protein-coding
10q22.1
Ensembl:ENSG00000197467 MIM:120350 Vega:OTTHUMG00000018394 UniprotKB:Q5TAT6
NG_046344.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.259e-1 (AD)  4.521e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs942568chr10:69897865 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27268279chr10:71672083COL13A12.670e-8Maternal smoking in pregnancy27040690
cg27268279chr10:71672083COL13A16.190e-9Maternal smoking in pregnancy27040690
cg27268279chr10:71672083COL13A11.090e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTGIS0.607
COL12A10.595
TASP10.58
LTBP40.573
GLT8D20.567
JAG20.566
SCARA50.565
ZNF8600.563
SAMD50.562
EPHA30.554

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD3-0.451
BMPR1B-0.424
RFX4-0.418
EYA2-0.418
KLF15-0.413
TPD52L1-0.411
IL17RB-0.406
BBOX1-0.406
PAX6-0.404
PIR-0.402

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of COL13A1 mRNA"25710175
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of COL13A1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COL13A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COL13A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of COL13A1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of COL13A1 mRNA17562736
D000447AldehydesAldehydes results in increased expression of COL13A1 mRNA25014914
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of COL13A1 mRNA"22863853
C547126AZM551248AZM551248 results in decreased expression of COL13A1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of COL13A1 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of COL13A1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of COL13A1 mRNA22610609
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of COL13A1 mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of COL13A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of COL13A1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of COL13A1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of COL13A1 mRNA26079696
D002922CiguatoxinsCiguatoxins affects the expression of COL13A1 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of COL13A1 mRNA24386269
D003561CytarabineCytarabine results in decreased expression of COL13A1 mRNA21198554
C014347decitabinedecitabine affects the expression of COL13A1 mRNA23300844
D003907DexamethasoneDexamethasone results in decreased expression of COL13A1 mRNA25047013
D002945CisplatinCisplatin affects the expression of COL13A1 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of COL13A1 mRNA19561079
D002117CalcitriolCalcitriol results in increased expression of COL13A1 mRNA16002434|2648566
C118739entinostatentinostat results in increased expression of COL13A1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL13A1 mRNA17942748
D005411Flame RetardantsFlame Retardants results in increased expression of COL13A1 mRNA27219277
C010974glyphosateglyphosate results in increased expression of COL13A1 mRNA25636363
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in increased expression of COL13A1 mRNA27219277
C051890irinotecanirinotecan analog results in increased expression of COL13A1 mRNA18927307
D007529IsoflavonesIsoflavones affects the expression of COL13A1 mRNA16365062
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL13A1 mRNA26752646
C008261lead acetatelead acetate results in decreased expression of COL13A1 mRNA11578147
D018021Lithium ChlorideLithium Chloride results in decreased expression of COL13A1 mRNA23527032
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of COL13A1 mRNA23179753
D015735MifepristoneMifepristone results in decreased expression of COL13A1 mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of COL13A1 mRNA26924002
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of COL13A1 mRNA24888373
C030110oxaliplatinoxaliplatin results in decreased expression of COL13A1 mRNA16510598
D010100OxygenOxygen deficiency results in decreased expression of COL13A1 mRNA26516004
C016030pantogabpantogab results in increased expression of COL13A1 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased methylation of COL13A1 gene28495853
C046012pentanalpentanal results in increased expression of COL13A1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of COL13A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of COL13A1 mRNA26272509
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of COL13A1 mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in increased expression of COL13A1 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of COL13A1 mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of COL13A1 mRNA20660070
C005556propionaldehydepropionaldehyde results in increased expression of COL13A1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of COL13A1 mRNA24780913
C078903seocalcitolseocalcitol results in increased expression of COL13A1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of COL13A1 mRNA25895662
D019821SimvastatinCOL13A1 SNP results in decreased susceptibility to Simvastatin21483694
C017947sodium arsenitesodium arsenite results in decreased expression of COL13A1 mRNA20371982
D012999SomanSoman results in increased expression of COL13A1 mRNA19281266
D053260SootSoot results in decreased expression of COL13A1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL13A1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL13A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL13A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL13A1 mRNA16120747
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in decreased expression of COL13A1 mRNA23825117
D014212TretinoinTretinoin results in decreased expression of COL13A1 mRNA23830798
D014212TretinoinTretinoin results in increased expression of COL13A1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of COL13A1 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of COL13A1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of COL13A1 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of COL13A1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of COL13A1 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in decreased methylation of COL13A1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of COL13A1 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of COL13A1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of COL13A1 gene28495853
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in decreased expression of COL13A1 mRNA23825117
D014800VitalliumVitallium analog results in decreased expression of COL13A1 mRNA23825117
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of COL13A1 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0005515protein binding-IPI11956183  
GO:0008201heparin binding-IBA21873635  
GO:0008201heparin binding-IDA11956183  
GO ID GO Term Qualifier Evidence PubMed
GO:0001763morphogenesis of a branching structure-IBA21873635  
GO:0001763morphogenesis of a branching structure-ISS-  
GO:0001958endochondral ossification-ISS-  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007160cell-matrix adhesion-IPI11956183  
GO:0030154cell differentiation-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0030574collagen catabolic process-TAS-  
GO:0098609cell-cell adhesion-IBA21873635  
GO:0098609cell-cell adhesion-IEP10865988  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005600collagen type XIII trimer-TAS2459707  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29654602A Genome-Wide Association Study identifies new genes potentially associated with eyelid sagging. (2018 Apr 13)Laville VExp Dermatol