Gene: ALS2CR12

130540
-
amyotrophic lateral sclerosis 2 chromosome region 12
protein-coding
2q33.1
Ensembl:ENSG00000155749 Vega:OTTHUMG00000132824 UniprotKB:Q96Q35
NC_000002.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
1.799e-1 (AD)  7.311e-1 (ND)   (Frontal_Cortex)
2.546e-1 (AD)  3.777e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9288318chr2:201331340 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH20.655
TRIM520.649
EYA30.64
C15orf620.624
RAD520.623
CSPP10.622
RBM480.621
ZSCAN220.619
HIC20.617
FAM227A0.615

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRSS27-0.385
STARD6-0.357
C17orf64-0.32
GZMK-0.289
ZNF723-0.286
KLRB1-0.284
CD3G-0.284
IL18RAP-0.281
UGT3A2-0.28
CCT6B-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of ALS2CR12 mRNA25181051
D002104CadmiumCadmium results in decreased expression of ALS2CR12 mRNA24376830
D002945CisplatinCisplatin results in increased expression of ALS2CR12 mRNA27392435
D005485FlutamideFlutamide results in decreased expression of ALS2CR12 mRNA24793618
C412815GW 4064GW 4064 results in increased expression of ALS2CR12 mRNA26655953
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ALS2CR12 mRNA26911376
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ALS2CR12 mRNA"25620056
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ALS2CR12 mRNA27153767
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ALS2CR12 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ALS2CR12 mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of ALS2CR12 mRNA18301758
D017035PravastatinPravastatin results in increased expression of ALS2CR12 mRNA27225895
D017035PravastatinPravastatin results in increased expression of ALS2CR12 mRNA27225895
D011441PropylthiouracilPropylthiouracil results in increased expression of ALS2CR12 mRNA24780913
C075117squalestatin 1squalestatin 1 results in decreased expression of ALS2CR12 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of ALS2CR12 mRNA27225895
C012589trichostatin Atrichostatin A affects the expression of ALS2CR12 mRNA28542535
C057693troglitazonetroglitazone results in increased expression of ALS2CR12 mRNA28973697

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI16189514  19060904  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005737cytoplasm-IEA-  
GO:0031514motile cilium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28542283Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China. (2017)Zhao XKPLoS One