Gene: LYPD6

130574
-
LY6/PLAUR domain containing 6
protein-coding
2q23.2
Ensembl:ENSG00000187123 MIM:613359 Vega:OTTHUMG00000131852 UniprotKB:Q86Y78
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.020e-1 (AD)  8.754e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERBB40.85
SLC6A10.791
ABCD20.777
ACSL60.748
SALL20.743
ADCYAP1R10.732
CTNNA20.721
CHRDL10.718
ABAT0.717
WASF30.712

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SFN-0.494
GNG8-0.478
SGMS2-0.419
SPOCD1-0.415
BEST3-0.413
OR4F5-0.412
SERPINF2-0.411
NGFR-0.407
GABRE-0.399
STC1-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYPD6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYPD6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYPD6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYPD6 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of LYPD6 mRNA25064622
D020106AcrylamideAcrylamide results in increased expression of LYPD6 mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of LYPD6 mRNA25064622
C015001arsenitearsenite results in increased methylation of LYPD6 promoter23974009
C006780bisphenol Abisphenol A results in decreased expression of LYPD6 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of LYPD6 mRNA26079696
D002746ChlorpromazineChlorpromazine affects the expression of LYPD6 mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of LYPD6 mRNA19320972
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of LYPD6 mRNA19167446
D016572CyclosporineCyclosporine affects the expression of LYPD6 mRNA25064622
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LYPD6 mRNA21266533
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LYPD6 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of LYPD6 mRNA25064622
C492448ICG 001ICG 001 results in decreased expression of LYPD6 mRNA26191083
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LYPD6 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LYPD6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LYPD6 mRNA"25554681
D009532NickelNickel results in decreased expression of LYPD6 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of LYPD6 mRNA22714537
D010269ParaquatParaquat affects the expression of LYPD6 mRNA25064622
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYPD6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LYPD6 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of LYPD6 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of LYPD6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LYPD6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of LYPD6 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in decreased expression of LYPD6 mRNA24780913
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of LYPD6 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LYPD6 mRNA25895662
D012834SilverSilver results in decreased expression of LYPD6 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of LYPD6 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LYPD6 mRNA26377647
D013752TetracyclineTetracycline affects the expression of LYPD6 mRNA25064622
D013772TetramethylphenylenediamineLYPD6 gene SNP affects the susceptibility to Tetramethylphenylenediamine25622337
D013853ThioacetamideThioacetamide affects the expression of LYPD6 mRNA25064622
D014212TretinoinTretinoin results in increased expression of LYPD6 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of LYPD6 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of LYPD6 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LYPD6 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of LYPD6 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of LYPD6 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI27344019  
GO:0030550acetylcholine receptor inhibitor activity-IDA27344019  
GO ID GO Term Qualifier Evidence PubMed
GO:0099601regulation of neurotransmitter receptor activity-IEA-  
GO:2000272negative regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0031225anchored component of membrane-IEA-  
GO:0043005neuron projection-IEA-  
GO:0045121membrane raft-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29195920Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine. (2018 Mar 2)Arvaniti MProg Neuropsychopharmacol Biol Psychiatry