Gene: COL15A1

1306
-
collagen type XV alpha 1 chain
protein-coding
9q22.33
Ensembl:ENSG00000204291 MIM:120325 Vega:OTTHUMG00000020351 UniprotKB:P39059
NC_000009.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.502e-2 (AD)  4.085e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7031588chr9:99060020 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FER1L60.828
MROH50.818
GADL10.806
NMUR10.8
DPPA40.792
GSDMA0.791
IL2RB0.786
FCRL30.778
C2orf830.774
RNF170.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.412
ASPDH-0.395
C1orf53-0.393
SLC1A4-0.393
C9orf24-0.392
GABRG1-0.379
HHATL-0.378
CNTFR-0.374
NDP-0.368
CABLES1-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of COL15A1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of COL15A1 mRNA28959563
D000452AldrinAldrin results in increased expression of COL15A1 mRNA18579281
D000537Aluminum OxideAluminum Oxide results in increased expression of COL15A1 mRNA19464052
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of COL15A1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to COL15A1 promoter]19654925
D004958EstradiolEstradiol affects the expression of COL15A1 mRNA14699072
D004958EstradiolEstradiol promotes the reaction [ESR2 protein affects the expression of COL15A1 mRNA]20404318
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of COL15A1 mRNA20226447
C006780bisphenol Abisphenol A results in decreased expression of COL15A1 mRNA23798566
C006780bisphenol Abisphenol A affects the expression of COL15A1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of COL15A1 mRNA16997883
C018475butyraldehydebutyraldehyde results in increased expression of COL15A1 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of COL15A1 mRNA17484886
D002994ClofibrateClofibrate results in increased expression of COL15A1 mRNA17585979
D003042CocaineCocaine affects the expression of COL15A1 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of COL15A1 mRNA18579281
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of COL15A1 mRNA16997883
D003907DexamethasoneDexamethasone results in decreased expression of COL15A1 mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of COL15A1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of COL15A1 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of COL15A1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of COL15A1 mRNA27392435
D002945CisplatinCOL15A1 mRNA results in decreased susceptibility to Cisplatin25199881
D004041Dietary FatsDietary Fats results in increased expression of COL15A1 mRNA18042831
D004237DiuronDiuron results in increased expression of COL15A1 mRNA21551480
D004317DoxorubicinCOL15A1 mRNA results in decreased susceptibility to Doxorubicin25199881
D004317DoxorubicinDoxorubicin results in decreased expression of COL15A1 mRNA16243910
D004317DoxorubicinDoxorubicin results in increased expression of COL15A1 mRNA15033991
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COL15A1 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COL15A1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL15A1 mRNA17942748
D005047EtoposideCOL15A1 protein affects the susceptibility to Etoposide16217747
C039281furanfuran results in increased expression of COL15A1 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of COL15A1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of COL15A1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of COL15A1 mRNA16997883
D007545IsoproterenolIsoproterenol results in decreased expression of COL15A1 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL15A1 mRNA24435446
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of COL15A1 mRNA26644586
C008261lead acetatelead acetate results in decreased expression of COL15A1 mRNA22613225
C008261lead acetatelead acetate results in decreased expression of COL15A1 mRNA11578147
D008727MethotrexateCOL15A1 mRNA results in decreased susceptibility to Methotrexate25199881
D008727MethotrexateCOL15A1 protein affects the susceptibility to Methotrexate16217747
C029938nickel sulfatenickel sulfate results in decreased expression of COL15A1 mRNA16166746
D017239PaclitaxelCOL15A1 mRNA results in decreased susceptibility to Paclitaxel25199881
D000073878Palm OilPalm Oil results in increased expression of COL15A1 mRNA18042831
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of COL15A1 mRNA17715259
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of COL15A1 mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of COL15A1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of COL15A1 mRNA19482888
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of COL15A1 mRNA17715259
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of COL15A1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of COL15A1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of COL15A1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of COL15A1 mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of COL15A1 mRNA28903501
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of COL15A1 mRNA20226447
D011374ProgesteroneProgesterone results in increased expression of COL15A1 mRNA20226447
D011441PropylthiouracilPropylthiouracil results in decreased expression of COL15A1 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of COL15A1 mRNA22431001
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of COL15A1 mRNA25879800
D012969Sodium FluorideSodium Fluoride results in decreased expression of COL15A1 protein28918527
D012999SomanSoman results in increased expression of COL15A1 mRNA19281266
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA"18579281
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of COL15A1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL15A1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of COL15A1 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL15A1 mRNA16962184|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COL15A1 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of COL15A1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of COL15A1 mRNA]15667827
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL15A1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of COL15A1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of COL15A1 mRNA23557971
D019772TopotecanCOL15A1 mRNA results in decreased susceptibility to Topotecan25199881
C057693troglitazone[troglitazone co-treated with TNF protein] results in increased expression of COL15A1 mRNA12732648
D014635Valproic AcidValproic Acid affects the expression of COL15A1 mRNA25979313
D014750VincristineCOL15A1 mRNA results in decreased susceptibility to Vincristine25199881
D014752Vinyl ChlorideVinyl Chloride results in increased expression of COL15A1 mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0030020extracellular matrix structural constituent conferring tensile strength-HDA20551380  27068509  27559042  
GO:0030020extracellular matrix structural constituent conferring tensile strength-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-NAS10891348  
GO:0030154cell differentiation-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030574collagen catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005582collagen type XV trimer-TAS9651385  
GO:0005615extracellular space-HDA20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0016021integral component of membrane-NAS10891348  
GO:0062023collagen-containing extracellular matrix-HDA27068509  27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal