Gene: CPO

130749
-
carboxypeptidase O
protein-coding
2q33.3
Ensembl:ENSG00000144410 MIM:609563 Vega:OTTHUMG00000088987 UniprotKB:Q8IVL8
NG_028078.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.656e-1 (AD)  6.874e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPAG50.841
ABCC50.802
NAALAD20.793
KIAA07530.789
PASK0.781
HINFP0.78
TRIM110.778
ZNF2730.778
FAM153C0.777
AP4B10.775

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRB1-0.464
TIGIT-0.435
TFPI2-0.428
MDFI-0.423
LCK-0.417
MAPKAPK3-0.407
CD2-0.407
C9orf135-0.405
GZMA-0.392
TBX21-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of CPO mRNA18522720
D004958EstradiolEstradiol affects the expression of CPO mRNA16684588
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CPO mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of CPO mRNA26079696
D002104CadmiumCadmium results in decreased expression of CPO mRNA24376830
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CPO mRNA]27941970
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CPO mRNA23550701
C056933fumonisin B1fumonisin B1 results in decreased expression of CPO mRNA16221962
C008261lead acetatelead acetate results in decreased expression of CPO mRNA19737576
D010433PentylenetetrazolePentylenetetrazole affects the expression of CPO mRNA21503142
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CPO mRNA24819616
C006253pirinixic acidpirinixic acid results in increased expression of CPO mRNA16221962
D010936Plant ExtractsPlant Extracts results in decreased expression of CPO mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of CPO mRNA19690047
C059514resveratrolresveratrol results in increased expression of CPO mRNA23419489
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CPO mRNA23806026
D014284TriiodothyronineTriiodothyronine results in decreased expression of CPO mRNA19228888|2481961
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CPO mRNA15251184
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CPO mRNA"26743178

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004181metallocarboxypeptidase activity-IBA21873635  
GO:0004181metallocarboxypeptidase activity-IDA21921028  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0016324apical plasma membrane-IEA-  
GO:0046658anchored component of plasma membrane-IDA21921028  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11018766Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. (2000 Oct)Singh SUJ Endocrinol
21576080Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway. (2011 Aug)Boyles ALHum Reprod
14639706Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads. (2003 Dec)Jugessur AGenet Epidemiol
22497478Application of a novel hybrid study design to explore gene-environment interactions in orofacial clefts. (2012 May)Skare OAnn Hum Genet