Gene: CCDC148

130940
-
coiled-coil domain containing 148
protein-coding
2q24.1
Ensembl:ENSG00000153237 Vega:OTTHUMG00000153973 UniprotKB:Q8NFR7
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.995e-1 (AD)  1.773e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2602189chr2:158284712 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D320.734
ZDHHC150.734
BDP10.73
TRIQK0.726
NLGN10.724
MTMR70.724
CHM0.72
FTO0.719
NEU30.717
RGS170.716

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HIGD1B-0.369
PPP1R14B-0.362
ROM1-0.361
CDKN2C-0.355
ADAMTSL5-0.353
S100A1-0.35
CSAG1-0.346
GRTP1-0.341
PLIN4-0.341
SYPL2-0.338

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCDC148 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCDC148 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCDC148 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCDC148 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCDC148 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of CCDC148 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of CCDC148 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC148 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CCDC148 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of CCDC148 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CCDC148 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CCDC148 mRNA26079696
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CCDC148 mRNA27392435
C024565ethylene dichlorideethylene dichloride results in decreased expression of CCDC148 mRNA28189721
C039281furanfuran results in increased expression of CCDC148 mRNA27387713
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CCDC148 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CCDC148 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCDC148 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CCDC148 mRNA23649840
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CCDC148 mRNA"25510870
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CCDC148 mRNA23608068
C005556propionaldehydepropionaldehyde results in increased expression of CCDC148 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of CCDC148 mRNA24780913
C012589trichostatin Atrichostatin A affects the expression of CCDC148 mRNA28542535
D014635Valproic AcidValproic Acid affects the expression of CCDC148 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CCDC148 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CCDC148 gene25560391
C111237vorinostatvorinostat results in increased expression of CCDC148 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19060904  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal