Gene: ADH7

131
ADH4
AD dehydrogenase 7 (class IV), mu or sigma polypeptide
protein-coding
4q23
Ensembl:ENSG00000196344 MIM:600086 Vega:OTTHUMG00000159318 UniprotKB:P40394
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
22   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.339e-1 (AD)  6.253e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SERPINB30.914
DAZ10.888
SPINK50.886
MUC210.877
TMPRSS11B0.841
FGFBP10.828
KRT150.827
SPRR2F0.804
CT45A30.8
GBP60.776

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP3K6-0.217
FAM91A1-0.206
CLIP4-0.196
GSTCD-0.194
TCEAL3-0.192
ZC2HC1A-0.19
KLHL28-0.19
FBXL17-0.189
PAQR3-0.188
CPEB4-0.186

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalEnzyme
DB00898EthanolSmall Molecule64-17-5ApprovedEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ADH7 mRNA"22698814
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ADH7 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ADH7 mRNA19933214
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol]"19822198
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of ADH7 mRNA16014739
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ADH7 mRNA"20959002
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ADH7 mRNA"23196670
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ADH7 mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of ADH7 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ADH7 mRNA17562736
C000188alachloralachlor affects the expression of ADH7 mRNA19425180
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADH7 mRNA16483693
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA19737545
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADH7 mRNA19770486|2071347
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ADH7 mRNA26496021
C452139BIRB 796BIRB 796 results in increased expression of ADH7 mRNA24303162
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of ADH7 mRNA"20162321
C006780bisphenol Abisphenol A results in increased expression of ADH7 mRNA24586524
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ADH7 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of ADH7 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ADH7 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ADH7 mRNA14729362|1533650
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADH7 mRNA27339419
D002737ChloropreneChloroprene results in increased expression of ADH7 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADH7 mRNA20938992
D002927CimetidineCimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]23220590
D002994ClofibrateClofibrate results in decreased expression of ADH7 mRNA17585979
C023614dibenzofurandibenzofuran analog results in increased expression of ADH7 mRNA20566336
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of ADH7 mRNA23625948
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ADH7 mRNA19638242
D004237DiuronDiuron results in increased expression of ADH7 mRNA21551480
D000431Ethanol"2,6-dichloro-4-nitrophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol]"19822198
D000431EthanolADH7 protein results in increased metabolism of Ethanol19822198
D000431EthanolADH7 protein results in increased oxidation of Ethanol21167143|2322059
D000431EthanolCimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]23220590
D000431Ethanolfomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]21167143
D000431EthanolPentachlorophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol]19822198
D019855Ethylene GlycolADH7 protein results in increased oxidation of Ethylene Glycol21167143
D015025ZearalenoneZearalenone results in decreased expression of ADH7 protein25058043
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ADH7 mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of ADH7 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADH7 mRNA20938992
C010238fomepizolefomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]21167143
C039281furanfuran results in increased methylation of ADH7 gene22079235
C412815GW 4064GW 4064 results in increased expression of ADH7 mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ADH7 mRNA14729362
C525593JK184JK184 binds to and results in decreased activity of ADH7 protein19222062
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of ADH7 protein17337753
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ADH7 mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADH7 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ADH7 mRNA20713471
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADH7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ADH7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of ADH7 protein"25598225
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ADH7 mRNA17616710
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of ADH7 mRNA23212921
C016030pantogabpantogab results in increased expression of ADH7 mRNA17379144
D010416PentachlorophenolPentachlorophenol inhibits the reaction [ADH7 protein results in increased metabolism of Ethanol]19822198
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ADH7 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ADH7 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ADH7 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ADH7 mRNA17681415|1846767
C023036perfluorooctanoic acidPPARA protein inhibits the reaction [perfluorooctanoic acid results in decreased expression of ADH7 mRNA]18467677
D010634PhenobarbitalPhenobarbital affects the expression of ADH7 mRNA23091169
C006253pirinixic acidpirinixic acid results in increased expression of ADH7 mRNA18301758
D017035PravastatinPravastatin results in decreased expression of ADH7 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of ADH7 mRNA27225895
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ADH7 mRNA28903501
D0198402-PropanolADH7 protein results in increased oxidation of 2-Propanol21167143
D012172RetinaldehydeADH7 protein results in increased chemical synthesis of Retinaldehyde17473173
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ADH7 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of ADH7 mRNA23221170
D012834SilverSilver results in increased expression of ADH7 mRNA27131904
D012906SmokeSmoke affects the expression of ADH7 mRNA23693141
C075117squalestatin 1squalestatin 1 affects the expression of ADH7 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of ADH7 mRNA27225895
C501413tesaglitazartesaglitazar results in increased expression of ADH7 mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of ADH7 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADH7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADH7 mRNA15667827|1703548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADH7 mRNA20959002|2121527
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ADH7 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of ADH7 mRNA23557971
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of ADH7 mRNA24096154
D014028Tobacco Smoke PollutionNFE2L2 protein promotes the reaction [Tobacco Smoke Pollution affects the expression of ADH7 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADH7 mRNA20133372
C057693troglitazonetroglitazone results in increased expression of ADH7 mRNA21515302
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADH7 gene25560391
D014801Vitamin AADH7 protein results in increased oxidation of Vitamin A17473173
D014810Vitamin EVitamin E results in decreased expression of ADH7 mRNA19244175
C574123walrycin Awalrycin A results in increased expression of ADH7 mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004022alcohol dehydrogenase (NAD) activity-TAS8074657  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-EXP9982  
GO:0004024alcohol dehydrogenase activity, zinc-dependent-IDA7876099  
GO:0004031aldehyde oxidase activity-IDA9600267  
GO:0004745retinol dehydrogenase activity-IDA7876099  11997393  
GO:0008270zinc ion binding-IEA-  
GO:0019841retinol binding-IDA9228021  
GO:0035276ethanol binding-IDA9228021  
GO:0048019receptor antagonist activity-IDA9600267  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-IDA9600267  
GO:0006068ethanol catabolic process-IEA-  
GO:0006069ethanol oxidation-IDA7876099  10969996  
GO:0006069ethanol oxidation-TAS-  
GO:0009617response to bacterium-IDA11410738  
GO:0010430fatty acid omega-oxidation-IDA9600267  
GO:0042572retinol metabolic process-IEA-  
GO:0042573retinoic acid metabolic process-IEA-  
GO:0045471response to ethanol-IDA9600267  
GO:0055114oxidation-reduction process-IDA7876099  
GO:1900116extracellular negative regulation of signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00071Fatty acid degradation
hsa00350Tyrosine metabolism
hsa00830Retinol metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
19861527Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (2009 Nov)Oze ICancer Epidemiol Biomarkers Prev
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
24512552Single-nucleotide polymorphisms interact to affect ADH7 transcription. (2014 Apr)Jairam SAlcohol Clin Exp Res
12050823A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity. (2002 Jul)Osier MVAm J Hum Genet
23019235Rare ADH variant constellations are specific for alcohol dependence. (2013 Jan-Feb)Zuo LAlcohol Alcohol
20714161Using a pharmacokinetic model to relate an individual's susceptibility to alcohol dependence to genotypes. (2010)Mustavich LFHum Hered
19193628ADH single nucleotide polymorphism associations with alcohol metabolism in vivo. (2009 Apr 15)Birley AJHum Mol Genet
15048643Possible epistatic role of ADH7 in the protection against alcoholism. (2004 Apr 1)Osier MVAm J Med Genet B Neuropsychiatr Genet
23387924Genome-wide DNA methylation analysis in alcohol dependence. (2013 Mar)Zhang RAddict Biol
25270064Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. (2014 Dec)Peng QAm J Med Genet B Neuropsychiatr Genet
16385178Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. (2005 Dec)Han YAlcohol Clin Exp Res
24397210Expression of alcoholism-relevant genes in the liver are differently correlated to different parts of the brain. (2013)Wang LGene Expr
17185388Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. (2007 Feb 15)Luo XHum Mol Genet
28453170Variation in gastric alcohol dehydrogenase and the risk of alcohol dependence. (2016)Calka PArch Med Sadowej Kryminol
23468174Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. (2013 Jul)Zuo LHum Genet
28731573Effect of alcohol dehydrogenase-1B and -7 polymorphisms on blood ethanol and acetaldehyde concentrations in healthy subjects with a history of moderate alcohol consumption. (2018 Mar)Pastorino RDrug Test Anal
21940907Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. (2011 Nov)Hakenewerth AMCancer Epidemiol Biomarkers Prev
25527893Protective variant associated with alcohol dependence in a Mexican American cohort. (2014 Dec 21)Norden-Krichmar TMBMC Med Genet
23456092Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. (2013 Jun)Park BLHum Genet
18382665Ethnic related selection for an ADH Class I variant within East Asia. (2008 Apr 2)Li HPLoS One
24680035Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. (2014 Jun)Ahrens WOral Oncol