Gene: COL19A1

1310
COL9A1L|D6S228E
collagen type XIX alpha 1 chain
protein-coding
6q13
Ensembl:ENSG00000082293 MIM:120165 Vega:OTTHUMG00000014987 UniprotKB:Q14993
NC_000006.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.424e-1 (AD)  1.330e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDHAC10.847
ARHGAP200.843
PCDHAC20.838
GABRG30.836
XKR40.835
KCNH10.834
SLC4A80.832
PPM1E0.832
SCN8A0.828
CDH70.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.586
STON2-0.577
RAB13-0.577
IMPA2-0.567
COPZ2-0.559
AGTRAP-0.553
HVCN1-0.55
GNG5-0.547
TMEM176A-0.545
NBPF10-0.54

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D020106AcrylamideAcrylamide results in decreased expression of COL19A1 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of COL19A1 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of COL19A1 gene27153756
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of COL19A1 mRNA"22863853
C006780bisphenol Abisphenol A results in increased expression of COL19A1 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of COL19A1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of COL19A1 mRNA29097150
D060729Coal AshCoal Ash results in increased expression of COL19A1 mRNA19000753
D019422Dietary SucroseDietary Sucrose results in increased expression of COL19A1 mRNA26033743
D007213IndomethacinIndomethacin results in increased expression of COL19A1 mRNA28201806
C008261lead acetatelead acetate results in increased expression of COL19A1 mRNA20542052
C008261lead acetatelead acetate results in decreased expression of COL19A1 mRNA11578147
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of COL19A1 mRNA"20188158
C006253pirinixic acidpirinixic acid results in increased expression of COL19A1 mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in increased expression of COL19A1 mRNA23608068
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of COL19A1 mRNA27029645
C009277sodium arsenatesodium arsenate results in increased expression of COL19A1 mRNA21795629
D013096SpermineSpermine results in increased expression of COL19A1 mRNA18673383
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of COL19A1 mRNA]14728982
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of COL19A1 mRNA14728982
D014635Valproic AcidValproic Acid results in decreased methylation of COL19A1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of COL19A1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of COL19A1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of COL19A1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0005201extracellular matrix structural constituent-NAS1639419  7775380  
GO:0030674protein binding, bridging-NAS1639419  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS9143499  
GO:0007155cell adhesion-NAS7775380  
GO:0007519skeletal muscle tissue development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030198extracellular matrix organization-NAS1639419  
GO:0030574collagen catabolic process-TAS-  
GO:0098609cell-cell adhesion-NAS1639419  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-NAS7775380  
GO:0005615extracellular space-IBA21873635  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0031012extracellular matrix-NAS1639419  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25991709Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions. (2015 Aug)Cook MNPhysiol Genomics