Gene info: ID 1311

Gene: COMP

GENE ID: 1311

Synonyms: EDM1|EPD1|MED|PSACH|THBS5|TSP5

Description: cartilage oligomeric matrix protein

Gene type: protein-coding

Location: 19p13.11

dbXrefs: Ensembl:ENSG00000105664 MIM:600310 Vega:OTTHUMG00000169318 UniprotKB:P49747

RefSeq: NG_007070.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.132e-1 (AD) 3.535e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TTN	0.692
XIRP2	0.681
CLDN19	0.679
AMPD1	0.66
NEB	0.639
PLA2G2A	0.639
HOXC9	0.637
HOXB4	0.626
FLG	0.62
HOXC12	0.607

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF575	-0.249
SHBG	-0.224
CCL27	-0.218
TEX29	-0.209
FATE1	-0.208
SAC3D1	-0.202
HDDC3	-0.201
IFI27L1	-0.197
ZNRF4	-0.196
OR2T33	-0.194

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01373	Calcium	Small Molecule	7440-70-2	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of COMP mRNA"	18648102
C496492	abrine	abrine results in increased expression of COMP mRNA	22595364
D000082	Acetaminophen	Acetaminophen results in increased expression of COMP mRNA	22230336
D020106	Acrylamide	Acrylamide results in decreased expression of COMP mRNA	28959563
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of COMP mRNA	19464052
C547126	AZM551248	AZM551248 results in increased expression of COMP mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of COMP mRNA	20106945\|2231617
D004958	Estradiol	Estradiol results in increased expression of COMP mRNA	20106945\|2163298
C006780	bisphenol A	bisphenol A results in decreased expression of COMP mRNA	25181051
D001761	Bleomycin	[S1PR5 protein affects the susceptibility to Bleomycin] which affects the expression of COMP protein	29033951
C018475	butyraldehyde	butyraldehyde results in increased expression of COMP mRNA	26079696
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of COMP mRNA	16122865
D003471	Cuprizone	Cuprizone results in increased expression of COMP mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of COMP mRNA	25562108
D004041	Dietary Fats	Dietary Fats results in increased expression of COMP mRNA	18042831
C058705	diethyl malate	diethyl malate affects the expression of COMP mRNA	24814887
D002117	Calcitriol	Calcitriol results in decreased expression of COMP mRNA	26485663
C070609	EMD 53998	EMD 53998 analog results in increased expression of COMP mRNA	24977338
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of COMP mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMP mRNA	17942748
C082360	fipronil	fipronil results in increased methylation of COMP gene	28536466
C039281	furan	furan results in increased expression of COMP mRNA	25539665\|2619464
D015735	Mifepristone	Mifepristone results in decreased expression of COMP mRNA	25972201
C012655	nimesulide	nimesulide results in decreased expression of COMP protein	12166616
D000073878	Palm Oil	Palm Oil results in increased expression of COMP mRNA	18042831
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of COMP mRNA	24780913
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of COMP mRNA	27914987
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COMP mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COMP mRNA	20067830
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMP mRNA	17942748
C009495	titanium dioxide	titanium dioxide results in increased expression of COMP mRNA	23131501
D014520	Urethane	Urethane results in increased expression of COMP mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of COMP mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of COMP mRNA	23179753\|2519280
D014635	Valproic Acid	Valproic Acid affects the expression of COMP mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of COMP gene	25560391
D015032	Zinc	Zinc deficiency results in increased expression of COMP mRNA	12888634
C088658	zoledronic acid	zoledronic acid results in increased expression of COMP protein	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	18485748
GO:0005201	extracellular matrix structural constituent	-	TAS	7713493
GO:0005509	calcium ion binding	-	IDA	10852928 11084047
GO:0005515	protein binding	-	IPI	12225811 15075323 16051604 16611630 17588949 18485748 25416956
GO:0005518	collagen binding	-	IDA	11084047
GO:0008201	heparin binding	-	IDA	17588949
GO:0043395	heparan sulfate proteoglycan binding	-	IDA	17588949

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001501	skeletal system development	-	TAS	7670472
GO:0003417	growth plate cartilage development	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0007155	cell adhesion	-	IEA	-
GO:0009887	animal organ morphogenesis	-	TAS	7713493
GO:0030198	extracellular matrix organization	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IDA	17993464
GO:0060173	limb development	-	IDA	16542502

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	HDA	27068509
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	HDA	20551380
GO:0031012	extracellular matrix	-	TAS	7713493
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04350	TGF-beta signaling pathway
hsa04510	Focal adhesion
hsa04512	ECM-receptor interaction
hsa05144	Malaria

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-216083	Integrin cell surface interactions	TAS
R-HSA-3000178	ECM proteoglycans	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28925406	Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population. (2018 Feb)	Genske F	Int J Obes (Lond)
23690656	Serum matrix metalloproteinase-3 in comparison with acute phase proteins as a marker of disease activity and radiographic damage in early rheumatoid arthritis. (2013)	Ally MM	Mediators Inflamm
22870681	[Serum levels of cartilage oligomeric matrix protein in the diagnosis of knee osteoarthritis]. (2012 May)	Li H	Zhongguo Gu Shang