Gene info: ID 1312

Gene: COMT

GENE ID: 1312

Synonyms: HEL-S-98n

Description: catechol-O-methyltransferase

Gene type: protein-coding

Location: 22q11.21

dbXrefs: Ensembl:ENSG00000093010 MIM:116790 Vega:OTTHUMG00000150529 UniprotKB:P21964

RefSeq: NG_011526.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 157

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.410e-1 (AD) 6.973e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DDR1	0.897
SLC25A1	0.888
CD81	0.882
TMED1	0.881
PHGDH	0.877
RAMP1	0.87
PTGDS	0.869
CSRP1	0.869
PRDX6	0.868
FXYD1	0.866

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.6
OR4F29	-0.592
CDH7	-0.371
TYRP1	-0.365
CCDC68	-0.363
GABRG3	-0.356
COL19A1	-0.354
ZNF860	-0.352
EPHA3	-0.351
PROKR2	-0.35

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00118	Ademetionine	Small Molecule	29908-03-0	Approved\|Investigational\|Nutraceutical	Target
DB00323	Tolcapone	Small Molecule	134308-13-7	Approved\|Withdrawn	Target
DB00494	Entacapone	Small Molecule	130929-57-6	Approved\|Investigational	Target
DB02105	3,5-Dinitrocatechol	Small Molecule		Experimental	Target
DB02342	2-Methoxyestradiol	Small Molecule	362-07-2	Investigational	Target
DB03336	BIA	Small Molecule	-	Experimental	Target
DB03907	N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide	Small Molecule		Experimental	Target
DB04820	Nialamide	Small Molecule	51-12-7	Withdrawn	Target
DB07462	(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE	Small Molecule		Experimental	Target
DB08049	7,8-dihydroxy-4-phenyl-2H-chromen-2-one	Small Molecule		Experimental	Target
DB00255	Diethylstilbestrol	Small Molecule	56-53-1	Approved\|Investigational	Enzyme
DB00286	Conjugated estrogens	Small Molecule	12126-59-9	Approved	Enzyme
DB00494	Entacapone	Small Molecule	130929-57-6	Approved\|Investigational	Enzyme
DB00841	Dobutamine	Small Molecule	34368-04-2	Approved	Enzyme
DB00968	Methyldopa	Small Molecule	555-30-6	Approved	Enzyme
DB00988	Dopamine	Small Molecule	51-61-6	Approved	Enzyme
DB01141	Micafungin	Small Molecule	235114-32-6	Approved\|Investigational	Enzyme
DB01420	Testosterone propionate	Small Molecule	57-85-2	Approved\|Investigational\|Withdrawn	Enzyme
DB06152	Nylidrin	Small Molecule	447-41-6	Approved	Enzyme

ID	Drug Name	Action	PubMed
C048152	1-carboxysalsolinol	COMT protein results in increased methylation of 1-carboxysalsolinol	11160877
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of COMT mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased activity of COMT protein"	22750137
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of COMT mRNA"	20702594
C053499	2,3-dihydroxynaphthalene	"COMT protein results in increased methylation of 2,3-dihydroxynaphthalene"	11160877
C053499	2,3-dihydroxynaphthalene	"COMT protein results in increased methylation of 2,3-dihydroxynaphthalene"	11160877
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"COMT protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	12901791
C475868	2-hydroxy-3-methoxyestradiol	COMT protein affects the chemical synthesis of 2-hydroxy-3-methoxyestradiol	15377160
C001390	2-hydroxyestradiol	COMT protein affects the metabolism of 2-hydroxyestradiol	15377160
C001390	2-hydroxyestradiol	COMT protein results in increased methylation of 2-hydroxyestradiol	11160877
C001390	2-hydroxyestradiol	COMT protein results in increased methylation of 2-hydroxyestradiol	11160877
C001390	2-hydroxyestradiol	COMT protein results in increased metabolism of 2-hydroxyestradiol	20600213
C001390	2-hydroxyestradiol	COMT protein results in increased metabolism of and results in decreased activity of 2-hydroxyestradiol	18497090
C022830	2-methoxyestradiol	COMT protein affects the chemical synthesis of 2-methoxyestradiol	15377160
C022830	2-methoxyestradiol	COMT protein results in increased chemical synthesis of 2-methoxyestradiol	15292328\|2060021
C423629	3,4,5,6-tetrachlorocatechol	"COMT protein results in increased methylation of 3,4,5,6-tetrachlorocatechol"	11160877
C032940	3,4-dihydroxyacetophenone	"COMT protein results in increased methylation of 3,4-dihydroxyacetophenone"	11160877
C000989	3,4-dihydroxymandelic acid	"COMT protein results in increased methylation of 3,4-dihydroxymandelic acid"	11160877
C051800	3,4-methylenedioxyethamphetamine	"3,4-methylenedioxyethamphetamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]"	19462939
C051800	3,4-methylenedioxyethamphetamine	"COMT protein alternative form results in increased methylation of 3,4-methylenedioxyethamphetamine"	19462939
C051800	3,4-methylenedioxyethamphetamine	"3,4-methylenedioxyethamphetamine results in decreased activity of COMT protein"	19462939
C066344	3-methoxycatechol	COMT protein results in increased methylation of 3-methoxycatechol	11160877
C025525	3-O-methylgallic acid	COMT protein results in increased methylation of 3-O-methylgallic acid	11160877
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of COMT mRNA"	26186136
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of COMT mRNA"	21346803
C038861	4-chlorocatechol	COMT protein results in increased methylation of 4-chlorocatechol	11160877
C038861	4-chlorocatechol	COMT protein results in increased methylation of 4-chlorocatechol	11160877
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of COMT mRNA	12419474
C014036	4-hydroxyestradiol	COMT protein affects the metabolism of 4-hydroxyestradiol	15377160
C014036	4-hydroxyestradiol	COMT protein results in increased methylation of 4-hydroxyestradiol	18192686
C014036	4-hydroxyestradiol	daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]	18192686
C014036	4-hydroxyestradiol	Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]	18192686
C014036	4-hydroxyestradiol	Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]	18192686
C014036	4-hydroxyestradiol	COMT protein results in increased metabolism of 4-hydroxyestradiol	20600213
C014036	4-hydroxyestradiol	COMT protein results in increased metabolism of and results in decreased activity of 4-hydroxyestradiol	18497090
C013074	4-isopropylcatechol	COMT protein results in increased methylation of 4-isopropylcatechol	11160877
C013074	4-isopropylcatechol	COMT protein results in increased methylation of 4-isopropylcatechol	11160877
C045018	4-methoxyestradiol	COMT protein results in increased chemical synthesis of 4-methoxyestradiol	20600213
C018599	4-methylcatechol	COMT protein results in increased methylation of 4-methylcatechol	11160877
C018599	4-methylcatechol	COMT protein results in increased methylation of 4-methylcatechol	11160877
C001833	4-nitrocatechol	COMT protein results in increased methylation of 4-nitrocatechol	11160877
C001833	4-nitrocatechol	COMT protein results in increased methylation of 4-nitrocatechol	11160877
C027802	5-hydroxydopamine	COMT protein results in increased methylation of 5-hydroxydopamine	11160877
D000082	Acetaminophen	Acetaminophen affects the expression of COMT mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of COMT mRNA	17202762\|1824654
D000255	Adenosine Triphosphate	[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate	14975680
D000255	Adenosine Triphosphate	[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate	14975680
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine results in decreased activity of COMT protein	10064789
D012436	S-Adenosylmethionine	[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]	16758261
D012436	S-Adenosylmethionine	[S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol	20196537
D000438	Alcohols	COMT affects the susceptibility to Alcohols	18684228
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of COMT protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of COMT protein	26597043
D000616	Aminoglutethimide	Aminoglutethimide results in increased expression of COMT protein	26102013
D006710	Homocysteine	[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]	16758261
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of COMT mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in increased expression of COMT mRNA	12420312
D003913	Dextroamphetamine	COMT gene SNP affects the susceptibility to Dextroamphetamine	12716966
D000661	Amphetamine	Amphetamine results in increased expression of COMT mRNA	16916582
D000661	Amphetamine	COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine]	14574438
D000701	Analgesics, Opioid	"COMT affects the susceptibility to Analgesics, Opioid"	23748253
C034020	anthracene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA	28710019
C034020	anthracene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein	28710019
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of COMT mRNA	24449571
D000068180	Aripiprazole	Aripiprazole results in increased expression of COMT mRNA	17868501
D001280	Atrazine	Atrazine results in decreased expression of COMT mRNA	25929836
C028559	bathocuproine sulfonate	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA]	15477007
D001545	Benserazide	COMT protein results in increased methylation of Benserazide	11160877
D001545	Benserazide	COMT protein results in increased methylation of Benserazide	11160877
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of COMT mRNA	19770486
D001564	Benzo(a)pyrene	"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of COMT mRNA"	28987381
D004958	Estradiol	COMT protein polymorphism results in decreased abundance of Estradiol analog	15288375
D004958	Estradiol	COMT protein results in increased methylation of Estradiol metabolite	22285433
D004958	Estradiol	Estradiol inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]	18192686
D004958	Estradiol	Estradiol results in decreased activity of COMT protein	18192686\|1849709
D004958	Estradiol	Estradiol results in decreased expression of COMT mRNA	18497090\|2404016
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]	18192686\|1849709
D004958	Estradiol	Estradiol results in increased localization of COMT protein	9683193
D004958	Estradiol	Estradiol results in increased activity of COMT protein	20600213
D004958	Estradiol	Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein]	20600213
D004958	Estradiol	Catecholamines inhibits the reaction [COMT protein results in increased methylation of Estradiol]	15292328
D004958	Estradiol	COMT protein results in increased metabolism of and results in decreased activity of Estradiol	18566989
D004958	Estradiol	COMT protein results in increased methylation of Estradiol	15292328
C095105	bexarotene	bexarotene results in decreased expression of COMT mRNA	16648578
C095105	bexarotene	bexarotene results in increased expression of COMT mRNA	16648578
C466310	BIA 3-335	BIA 3-335 results in decreased activity of COMT protein	15566291
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of COMT mRNA	15912405
C006780	bisphenol A	bisphenol A results in decreased expression of COMT mRNA	24040167\|2421472
C006780	bisphenol A	bisphenol A results in increased methylation of COMT promoter	24214726
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA]	24040167
C006780	bisphenol A	bisphenol A results in decreased expression of COMT mRNA	26186136
C006780	bisphenol A	bisphenol A results in increased expression of COMT mRNA	25181051
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of COMT mRNA	24040167
C027561	butylbenzyl phthalate	fulvestrant inhibits the reaction [butylbenzyl phthalate results in decreased expression of COMT mRNA]	24040167
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of COMT mRNA	12419474
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of COMT protein	24394546
C584509	C646 compound	C646 compound results in increased expression of COMT mRNA	26191083
C040048	caffeic acid	COMT protein results in increased methylation of caffeic acid	11160877
D002230	Carbidopa	COMT protein results in increased methylation of Carbidopa	11160877
D002230	Carbidopa	COMT protein results in increased methylation of Carbidopa	11160877
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of COMT mRNA	16239168
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein	14975680
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	[Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate	14975680
C034221	catechol	COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]	24141029
C034221	catechol	COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]	24141029
C034221	catechol	COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]	24141029
C034221	catechol	COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol]	24141029
C034221	catechol	COMT mutant form results in increased susceptibility to catechol	24141029
C034221	catechol	COMT protein results in increased methylation of catechol	11160877
C034221	catechol	COMT protein results in increased methylation of catechol	11160877
C034221	catechol	[S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol	20196537
C034221	catechol	COMT protein results in increased methylation of catechol	24141029
C034221	catechol	[COMT protein results in increased methylation of catechol] which results in increased abundance of Guaiacol	24141029
D002395	Catecholamines	Catecholamines inhibits the reaction [COMT protein results in increased methylation of Estradiol]	15292328
D002395	Catecholamines	COMT protein affects the metabolism of Catecholamines	15292328
D002726	Chlorogenic Acid	Chlorogenic Acid results in decreased activity of COMT protein	27270453
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of COMT mRNA	18812211
D002922	Ciguatoxins	Ciguatoxins affects the expression of COMT mRNA	18353800
D003000	Clonidine	Clonidine results in increased expression of COMT mRNA	12423672
D003024	Clozapine	COMT gene polymorphism results in increased susceptibility to Clozapine	17123785
D003024	Clozapine	COMT protein affects the susceptibility to Clozapine	17123785
D003024	Clozapine	[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]	15190105
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of COMT mRNA	19320972\|1937684
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of COMT mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of COMT mRNA	19167446
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of COMT mRNA	21041162
D016572	Cyclosporine	Cyclosporine results in decreased expression of COMT mRNA	19770486
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of COMT mRNA	29038839
C004742	daidzein	daidzein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]	18192686
C004742	daidzein	daidzein results in decreased activity of COMT protein	18192686\|1849709
C004742	daidzein	daidzein results in decreased expression of COMT mRNA	18192686\|1849709
C004742	daidzein	fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA]	18192686\|1849709
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of COMT mRNA	23914054
D013759	Dronabinol	COMT protein polymorphism results in increased susceptibility to Dronabinol	16936704
D013759	Dronabinol	COMT affects the susceptibility to Dronabinol	20631688
C007262	deoxynivalenol	deoxynivalenol results in decreased phosphorylation of COMT protein	23811945
D003907	Dexamethasone	Dexamethasone results in increased expression of COMT mRNA	21041162
D003907	Dexamethasone	Dexamethasone results in increased expression of COMT mRNA	16962226\|2003205
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of COMT mRNA]	20032058
D003976	Diazinon	Diazinon results in decreased expression of COMT mRNA	18812211
D000072338	Dibenzofurans, Polychlorinated	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of COMT mRNA"	15858227
D000072338	Dibenzofurans, Polychlorinated	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in increased expression of COMT mRNA"	15858227
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of COMT mRNA	24040167
D003993	Dibutyl Phthalate	fulvestrant inhibits the reaction [Dibutyl Phthalate results in decreased expression of COMT mRNA]	24040167
D002945	Cisplatin	COMT gene SNP affects the susceptibility to Cisplatin	19898482
D002945	Cisplatin	Cisplatin results in increased expression of COMT protein	22023808
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA	15784690
D004026	Dieldrin	Dieldrin results in increased expression of COMT mRNA	18812211
D004041	Dietary Fats	Dietary Fats results in decreased expression of COMT mRNA	18042831
D004041	Dietary Fats	[Tetrachlorodibenzodioxin co-treated with Dietary Fats] results in decreased expression of COMT mRNA	20435547
D004041	Dietary Fats	Dietary Fats results in decreased expression of COMT protein	22715380
D004042	Dietary Fats, Unsaturated	"Dietary Fats, Unsaturated results in decreased expression of COMT mRNA"	23626681
D004042	Dietary Fats, Unsaturated	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of COMT mRNA"	23626681
C014476	diethyl maleate	diethyl maleate results in decreased expression of COMT mRNA	21161181
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA	18544905
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of COMT mRNA	21041162
C061532	dihydrexidine	COMT protein results in increased methylation of dihydrexidine	11160877
C061532	dihydrexidine	COMT protein results in increased methylation of dihydrexidine	11160877
D002117	Calcitriol	[Calcitriol co-treated with VDR protein] results in increased expression of COMT mRNA	27450565
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein binds to COMT promoter]	27450565
D015102	3,4-Dihydroxyphenylacetic Acid	"COMT protein results in increased methylation of 3,4-Dihydroxyphenylacetic Acid"	11160877
D015102	3,4-Dihydroxyphenylacetic Acid	"[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	11793163
D015102	3,4-Dihydroxyphenylacetic Acid	"COMT protein results in increased methylation of 3,4-Dihydroxyphenylacetic Acid"	11160877
D015102	3,4-Dihydroxyphenylacetic Acid	"[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	15190105\|1601287
D015102	3,4-Dihydroxyphenylacetic Acid	"[tolcapone results in decreased activity of COMT protein] promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]"	12957500
D015102	3,4-Dihydroxyphenylacetic Acid	"[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	12957500
C010117	dihydroxyphenylethylene glycol	COMT protein results in increased methylation of dihydroxyphenylethylene glycol	11160877
D004237	Diuron	Diuron results in decreased expression of COMT mRNA	21551480
D004280	Dobutamine	COMT protein results in increased methylation of Dobutamine	11160877
D004280	Dobutamine	Dobutamine results in increased expression of COMT mRNA	12423672
D007980	Levodopa	COMT gene polymorphism affects the susceptibility to Levodopa	18178571
D007980	Levodopa	COMT gene SNP affects the susceptibility to Levodopa	18698234
D007980	Levodopa	COMT protein results in increased methylation of Levodopa	11160877\|2320680
D007980	Levodopa	entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]	23206800
D007980	Levodopa	tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]	23206800
D007980	Levodopa	[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]	16758261
D007980	Levodopa	[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]	16758261
D007980	Levodopa	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa	10047930\|1080940
D007980	Levodopa	COMT protein results in increased methylation of Levodopa	11160877
D007980	Levodopa	Levodopa binds to COMT protein	12584150
D007980	Levodopa	[entacapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa	12588639
D004298	Dopamine	"3,4-methylenedioxyethamphetamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]"	19462939
D004298	Dopamine	COMT protein results in increased methylation of Dopamine	11160877
D004298	Dopamine	[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine	12898346
D004298	Dopamine	"N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]"	19462939
D004298	Dopamine	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine	11248589\|1289834
D004298	Dopamine	COMT protein results in increased metabolism of Dopamine	20626558
D004298	Dopamine	COMT protein affects the reaction [Amphetamine results in increased abundance of Dopamine]	14574438
D004298	Dopamine	COMT protein results in increased methylation of Dopamine	11160877
D004298	Dopamine	[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]	15190105
D004391	Dust	Dust results in decreased expression of COMT mRNA	17805423
D052244	Endocrine Disruptors	Endocrine Disruptors results in decreased expression of COMT mRNA	25198161
C071192	entacapone	entacapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]	23206800
C071192	entacapone	entacapone results in decreased activity of COMT protein	23206800
C071192	entacapone	[entacapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine	12898346
C071192	entacapone	entacapone results in decreased activity of COMT protein	15566291\|2033443
C071192	entacapone	entacapone binds to COMT protein	19783845
C071192	entacapone	entacapone results in decreased activity of COMT protein	19783845\|2033443
C071192	entacapone	entacapone results in decreased activity of COMT protein	10762340\|1124427
C071192	entacapone	[entacapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa	12588639
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of COMT mRNA	20064776
C045651	epigallocatechin gallate	epigallocatechin gallate binds to COMT protein	23010222
D004837	Epinephrine	COMT protein results in increased methylation of Epinephrine	11160877
D004837	Epinephrine	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine	11248589
D004837	Epinephrine	COMT protein results in increased methylation of Epinephrine	10064789
D004837	Epinephrine	[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine	10064789\|8821542
D004837	Epinephrine	tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]	8821542
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole] results in increased expression of COMT mRNA	29038839
C007628	esculetin	COMT protein results in increased methylation of esculetin	11160877
D004967	Estrogens	COMT gene polymorphism affects the metabolism of Estrogens	15777990
D004967	Estrogens	COMT protein affects the metabolism of Estrogens	15987428
D004967	Estrogens	Estrogens results in decreased expression of COMT protein	17138778
D002393	Estrogens, Catechol	"COMT protein polymorphism results in decreased metabolism of Estrogens, Catechol"	15288375
D002393	Estrogens, Catechol	"COMT protein results in increased methylation of and results in decreased activity of Estrogens, Catechol"	15455371
D002393	Estrogens, Catechol	"COMT protein results in increased metabolism of and results in decreased activity of Estrogens, Catechol"	18566989
D004970	Estrone	COMT protein results in increased methylation of Estrone metabolite	22285433
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased localization of COMT protein	9683193
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMT mRNA	17942748
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of COMT mRNA	28189721
C504383	fenbuconazole	fenbuconazole results in increased expression of COMT mRNA	15942997
C017875	fisetin	[fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein	16037419
C007738	fluoranthene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA	28710019
C007738	fluoranthene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein	28710019
D005459	Fluorides	COMT protein SNP results in increased susceptibility to Fluorides	25556215
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of COMT mRNA]	24040167
C070081	fulvestrant	fulvestrant inhibits the reaction [butylbenzyl phthalate results in decreased expression of COMT mRNA]	24040167
C070081	fulvestrant	fulvestrant inhibits the reaction [daidzein results in decreased expression of COMT mRNA]	18192686\|1849709
C070081	fulvestrant	fulvestrant inhibits the reaction [Dibutyl Phthalate results in decreased expression of COMT mRNA]	24040167
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in decreased expression of COMT mRNA]	18192686\|1849709
C070081	fulvestrant	fulvestrant inhibits the reaction [Genistein results in decreased expression of COMT mRNA]	18192686\|1849709
C039281	furan	furan results in decreased expression of COMT mRNA	26194646
C435770	gambierol	[Okadaic Acid co-treated with gambierol] results in decreased expression of COMT protein	19397276
D019833	Genistein	fulvestrant inhibits the reaction [Genistein results in decreased expression of COMT mRNA]	18192686\|1849709
D019833	Genistein	Genistein inhibits the reaction [COMT protein results in increased methylation of 4-hydroxyestradiol]	18192686
D019833	Genistein	Genistein results in decreased activity of COMT protein	18192686\|1849709
D019833	Genistein	Genistein results in decreased expression of COMT mRNA	18192686\|1849709
C004312	glycidol	glycidol results in increased expression of COMT mRNA	24915197
D006139	Guaiacol	COMT mutant form inhibits the reaction [catechol results in increased abundance of Guaiacol]	24141029
D006139	Guaiacol	COMT protein results in increased abundance of Guaiacol	24141029
D006139	Guaiacol	[COMT protein results in increased methylation of catechol] which results in increased abundance of Guaiacol	24141029
D006427	Hemin	COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of ALAS2 mRNA]	24141029
D006427	Hemin	COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HBB mRNA]	24141029
D006427	Hemin	COMT mutant form inhibits the reaction [[catechol co-treated with Hemin] results in increased expression of HMBS mRNA]	24141029
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of COMT protein	28214749
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of COMT protein	24365113
D006719	Homovanillic Acid	[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid	11793163
D006719	Homovanillic Acid	[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid	15190105\|1601287
C029424	hydrazine	hydrazine results in decreased expression of COMT protein	15370871
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of COMT mRNA	12419474
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of COMT mRNA	18951874
C492448	ICG 001	ICG 001 results in increased expression of COMT mRNA	26191083
C020758	indium trichloride	indium trichloride results in increased expression of COMT protein	19539025
D015759	Ionomycin	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA]	15477007
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA	15477007
D007545	Isoproterenol	COMT protein results in increased methylation of Isoproterenol	11160877
C410337	K 7174	K 7174 results in decreased expression of COMT mRNA	24086573
D007649	Ketamine	Ketamine results in increased expression of COMT mRNA	20080153
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of COMT mRNA	18544905
C067713	lactacystin	lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]	17138778
C035420	levodopa methyl ester	COMT protein results in increased methylation of levodopa methyl ester	11160877
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of COMT mRNA"	28987381
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of COMT mRNA"	18930950
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of COMT protein"	17573159
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of COMT protein"	17573159
D019290	Megestrol Acetate	Megestrol Acetate results in increased expression of COMT protein	16939895
D008628	Mercury	COMT gene polymorphism affects the susceptibility to Mercury	19296409
D008628	Mercury	COMT gene SNP affects the susceptibility to Mercury	24593143
D008676	Metanephrine	COMT protein results in increased chemical synthesis of Metanephrine	22569243
D008676	Metanephrine	[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine	10064789\|8821542
D008676	Metanephrine	tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]	8821542
D008694	Methamphetamine	COMT gene polymorphism affects the susceptibility to Methamphetamine	19462300
D008694	Methamphetamine	COMT gene polymorphism results in increased susceptibility to Methamphetamine	15274053
D008727	Methotrexate	Methotrexate results in increased expression of COMT mRNA	15120968
D008750	Methyldopa	COMT protein results in increased methylation of Methyldopa	11160877
D008750	Methyldopa	Methyldopa results in decreased activity of COMT protein	7053299
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"COMT protein affects the metabolism of and affects the susceptibility to N-Methyl-3,4-methylenedioxyamphetamine"	24591155
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"COMT protein affects the metabolism of and affects the susceptibility to N-Methyl-3,4-methylenedioxyamphetamine"	24591155
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of COMT mRNA]	12710931
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[tolcapone results in decreased activity of COMT protein] promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]"	12957500
C048833	modafinil	COMT gene polymorphism affects the susceptibility to modafinil	20815183
C048833	modafinil	COMT protein affects the susceptibility to modafinil	20815183
D009020	Morphine	[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine	21127283
D009020	Morphine	COMT protein affects the susceptibility to Morphine	18834357
C040015	myricetin	[myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein	16037419
C067181	N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine	"N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine results in decreased activity of COMT protein"	20726980
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of COMT mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of COMT mRNA"	25620056
C031721	naphthalene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA	28710019
C031721	naphthalene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein	28710019
D009281	Naphthalenes	Naphthalenes results in decreased expression of COMT protein	17337753
C433466	nebicapone	nebicapone results in decreased activity of COMT protein	20334432
C433466	nebicapone	COMT protein results in increased methylation of nebicapone	12584150
C433466	nebicapone	nebicapone binds to COMT protein	12584150
C433466	nebicapone	nebicapone results in decreased activity of COMT protein	12584150
D009532	Nickel	Nickel results in decreased expression of COMT mRNA	18812211
C028007	nickel monoxide	nickel monoxide results in increased expression of COMT mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in increased expression of COMT mRNA	18651567
C057364	nitecapone	nitecapone results in decreased activity of COMT protein	20726980
C506350	nitrocatechol	COMT protein results in increased methylation of nitrocatechol analog	11160877
C051570	N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine	"COMT protein results in increased methylation of N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine"	19462939
C051570	N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine	"N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine inhibits the reaction [COMT protein results in increased methylation of Dopamine]"	19462939
C051570	N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine	"N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine results in decreased activity of COMT protein"	19462939
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in decreased expression of COMT protein	19716841
D009638	Norepinephrine	COMT protein results in increased methylation of Norepinephrine	11160877
D009638	Norepinephrine	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine	11248589
D016627	Oxidopamine	COMT protein results in increased methylation of Oxidopamine	11160877
D019319	Okadaic Acid	[Okadaic Acid co-treated with gambierol] results in decreased expression of COMT protein	19397276
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of COMT protein	19397276
C076029	olanzapine	olanzapine results in increased expression of COMT mRNA	15964593
C057726	OR486	OR486 results in decreased activity of COMT protein	20726980
C057726	OR486	OR486 binds to COMT protein	12584150
C057726	OR486	OR486 results in decreased activity of COMT protein	10064789\|1258415
C057726	OR486	OR486 results in decreased activity of COMT protein	15292328\|1550751
D000073878	Palm Oil	Palm Oil results in decreased expression of COMT mRNA	18042831
C016030	pantogab	pantogab results in decreased expression of COMT mRNA	17379144
D010269	Paraquat	Paraquat results in increased expression of COMT mRNA	17935786
C003060	pentachlorobenzene	pentachlorobenzene results in decreased expression of COMT protein	24365113
C023036	perfluorooctanoic acid	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of COMT mRNA"	23626681
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of COMT mRNA	20118188\|2362668
C023036	perfluorooctanoic acid	PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of COMT mRNA]	20118188
C031181	phenanthrene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA	28710019
C031181	phenanthrene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein	28710019
D010634	Phenobarbital	Phenobarbital results in decreased expression of COMT mRNA	16510358
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of COMT mRNA"	17651324
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of COMT mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of COMT mRNA	18445702\|2081375
C006253	pirinixic acid	pirinixic acid results in decreased expression of COMT mRNA	16940010
D028321	Plant Preparations	COMT gene polymorphism affects the susceptibility to Plant Preparations	17602170
D011078	Polychlorinated Biphenyls	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of COMT mRNA"	15858227
D011078	Polychlorinated Biphenyls	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in increased expression of COMT mRNA"	15858227
D000072317	Polychlorinated Dibenzodioxins	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of COMT mRNA"	15858227
D000072317	Polychlorinated Dibenzodioxins	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in increased expression of COMT mRNA"	15858227
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of COMT mRNA	28710019
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons results in increased expression of and results in decreased activity of COMT protein	28710019
C019536	potassium bromate	potassium bromate results in increased expression of COMT mRNA	23588252
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of COMT mRNA	18332044
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of COMT mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of COMT protein	17138778
C009091	protocatechuic acid	COMT protein results in increased methylation of protocatechuic acid	11160877
C009091	protocatechuic acid	COMT protein results in increased methylation of protocatechuic acid	11160877
C010313	pseudocumene	pseudocumene results in decreased expression of COMT protein	17337753
C030984	pyrene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA	28710019
C030984	pyrene	[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein	28710019
D011748	Pyrogallol	COMT protein results in increased methylation of Pyrogallol	11160877
C020972	pyrrolidine dithiocarbamic acid	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA]	15477007
D011794	Quercetin	[Quercetin co-treated with COMT protein] results in decreased activity of DNMT1 protein	16037419
D011794	Quercetin	Quercetin inhibits the reaction [Estradiol results in increased activity of COMT protein]	20600213
D011794	Quercetin	Quercetin results in decreased activity of COMT protein	20600213
D011794	Quercetin	Quercetin results in decreased activity of COMT protein	15507517
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of COMT mRNA	19167446
D018967	Risperidone	Risperidone results in increased expression of COMT mRNA	15964593
C041376	rosmarinic acid	rosmarinic acid results in decreased activity of COMT protein	27270453
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of COMT mRNA	23221170
C006235	sinefungin	sinefungin results in decreased activity of COMT protein	26577531
C016104	sodium bichromate	sodium bichromate results in increased expression of COMT mRNA	12325037
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of COMT mRNA"	26680231
D013629	Tamoxifen	COMT protein affects the metabolism of Tamoxifen	15288375
D013629	Tamoxifen	Tamoxifen affects the expression of COMT mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in decreased expression of COMT mRNA	25123088
C038096	tert-butylcatechol	COMT protein results in increased methylation of tert-butylcatechol	11160877
C038096	tert-butylcatechol	COMT protein results in increased methylation of tert-butylcatechol	11160877
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of COMT mRNA]	20032058
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of COMT mRNA	26988606
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of COMT mRNA	20702594
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of COMT mRNA	16214954
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Dietary Fats] results in decreased expression of COMT mRNA	20435547
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of COMT mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COMT mRNA	18796159\|1977048
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of COMT mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of COMT mRNA	20959002
D013755	Tetradecanoylphorbol Acetate	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA]	15477007
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA	15477007
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"COMT protein results in increased methylation of 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"	11160877
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of COMT mRNA	28111298
C066340	tolcapone	tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]	23206800
C066340	tolcapone	tolcapone results in decreased activity of COMT protein	11248589\|1143253
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]	16758261
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]	16758261
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate	14975680
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid	11793163
C066340	tolcapone	"[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	11793163
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine	11248589\|1289834
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine	11248589
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa	10047930\|1080940
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine	11248589
C066340	tolcapone	tolcapone results in decreased activity of COMT protein	15566291\|2033443
C066340	tolcapone	COMT protein results in increased methylation of tolcapone	12584150
C066340	tolcapone	tolcapone binds to COMT protein	19783845
C066340	tolcapone	tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]	8821542
C066340	tolcapone	tolcapone results in decreased activity of COMT protein	10064789\|1519010
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]	15190105
C066340	tolcapone	[tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid	15190105\|1601287
C066340	tolcapone	"[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	15190105\|1601287
C066340	tolcapone	tolcapone results in decreased activity of COMT protein	12957500
C066340	tolcapone	"[tolcapone results in decreased activity of COMT protein] promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]"	12957500
C066340	tolcapone	"[tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid"	12957500
C066340	tolcapone	tolcapone results in decreased activity of COMT protein	10651109\|1977408
D014204	Trenbolone Acetate	Trenbolone Acetate results in decreased expression of COMT mRNA	25198161
D014212	Tretinoin	Tretinoin results in increased expression of COMT mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of COMT mRNA	19448997
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of COMT mRNA"	26179874
D014334	Tropolone	Tropolone results in decreased activity of COMT protein	10064789
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of COMT mRNA"	18930950
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of COMT mRNA]	12710931
C006104	U 0521	U 0521 results in decreased activity of COMT protein	2960778
D014635	Valproic Acid	Valproic Acid affects the expression of COMT mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of COMT mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of COMT mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of COMT gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of COMT gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of COMT mRNA	19165385
C025643	vinclozolin	vinclozolin affects the expression of COMT mRNA	19015723
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in decreased expression of COMT mRNA"	25198161
C029659	zearalenol	COMT protein results in increased methylation of zearalenol metabolite	22285433
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of COMT mRNA	15784690

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IEA	-
GO:0005515	protein binding	-	IPI	16189514 19060904
GO:0008168	methyltransferase activity	-	TAS	-
GO:0008171	O-methyltransferase activity	-	IBA	21873635
GO:0008171	O-methyltransferase activity	-	TAS	1707278
GO:0016206	catechol O-methyltransferase activity	-	IBA	21873635
GO:0016206	catechol O-methyltransferase activity	-	IDA	15645182 21846718
GO:0016206	catechol O-methyltransferase activity	-	TAS	-
GO:0102084	L-dopa O-methyltransferase activity	-	IEA	-
GO:0102938	orcinol O-methyltransferase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007565	female pregnancy	-	IEA	-
GO:0007612	learning	-	IEA	-
GO:0007614	short-term memory	-	IEA	-
GO:0008210	estrogen metabolic process	-	IEA	-
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0016036	cellular response to phosphate starvation	-	IEA	-
GO:0032259	methylation	-	TAS	-
GO:0032496	response to lipopolysaccharide	-	IEA	-
GO:0032502	developmental process	-	IBA	21873635
GO:0032502	developmental process	-	IEA	-
GO:0035814	negative regulation of renal sodium excretion	-	IEA	-
GO:0042135	neurotransmitter catabolic process	-	IEA	-
GO:0042417	dopamine metabolic process	-	IBA	21873635
GO:0042420	dopamine catabolic process	-	IEA	-
GO:0042424	catecholamine catabolic process	-	IBA	21873635
GO:0042424	catecholamine catabolic process	-	IDA	15645182 21846718
GO:0042493	response to drug	-	IEA	-
GO:0043627	response to estrogen	-	IEA	-
GO:0045963	negative regulation of dopamine metabolic process	-	IEA	-
GO:0048265	response to pain	-	IEA	-
GO:0048609	multicellular organismal reproductive process	-	IEA	-
GO:0048662	negative regulation of smooth muscle cell proliferation	-	IEA	-
GO:0050668	positive regulation of homocysteine metabolic process	-	IEA	-
GO:0051930	regulation of sensory perception of pain	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0016020	membrane	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0030424	axon	-	IBA	21873635
GO:0030424	axon	-	IEA	-
GO:0030425	dendrite	-	IBA	21873635
GO:0043197	dendritic spine	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0044297	cell body	-	IEA	-
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa00140	Steroid hormone biosynthesis
hsa00350	Tyrosine metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-112311	Neurotransmitter clearance	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156581	Methylation	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-379397	Enzymatic degradation of dopamine by COMT	TAS
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	TAS
R-HSA-379401	Dopamine clearance from the synaptic cleft	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23535252	Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors. (2013 Jun 25)	de la Salle S	Neuroscience
28746172	A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. (2017 Jul)	Xu J	Medicine (Baltimore)
23459442	COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. (2013 Dec)	Herman AI	Pharmacogenomics J
11244495	Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach. (2001 Jan)	Wang T	Mol Psychiatry
10898913	Lack of association between the functional variant of the catechol-o-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior. (2000 Jun 12)	Hallikainen T	Am J Med Genet
25556837	Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity. (2015 Jun)	Mouly S	Br J Clin Pharmacol
27825784	Does COMT val158met polymorphism influence P50 sensory gating, eye tracking or saccadic inhibition dysfunctions in schizophrenia? (2016 Dec 30)	Demily C	Psychiatry Res
19584770	Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events. (2009 Aug)	Breitling LP	Pharmacogenet Genomics
20188797	Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects. (2010 Apr 12)	Nedic G	Neurosci Lett
17636223	Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata. (2007 Feb)	Gooden KM	Reprod Sci
15941945	Catechol-O-methyl-transferase functional polymorphism and nicotine dependence: an evaluation of nonreplicated results. (2005 Jun)	Redden DT	Cancer Epidemiol Biomarkers Prev
17466074	Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (2007 Apr 28)	Ton TG	Behav Brain Funct
27490263	The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. (2016 Sep)	Li S	Am J Addict
18704099	Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. (2008 Dec)	Lohoff FW	Neuropsychopharmacology
14656940	Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility. (2004 Apr)	McGrath M	Carcinogenesis
25772090	Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain. (2015 Nov)	Omair A	Eur Spine J
17347351	Genetic and environmental influences on the development of alcoholism: resilience vs. risk. (2006 Dec)	Enoch MA	Ann N Y Acad Sci
10975602	Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers. (2000 Aug)	McKinney EF	Pharmacogenetics
16499480	Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. (2006 Mar)	Enoch MA	Alcohol Clin Exp Res
27426045	COMT and prenatal maternal smoking in associations with conduct problems and crime: the Pelotas 1993 birth cohort study. (2016 Jul 18)	Salatino-Oliveira A	Sci Rep
19170664	Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. (2009 Apr)	Wojnar M	Alcohol Clin Exp Res
18192898	Association of COMT Val108/158Met genotype with smoking cessation. (2008 Feb)	Munafo MR	Pharmacogenet Genomics
1570630	Effect of cadmium on some enzyme activities in first-trimester human placentae. (1992 Apr)	Boadi WY	Toxicol Lett
16395295	Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. (2006 Mar)	Beuten J	Neuropsychopharmacology
24273683	Withdrawal from Buprenorphine/Naloxone and Maintenance with a Natural Dopaminergic Agonist: A Cautionary Note. (2013 Apr 23)	Blum K	J Addict Res Ther
26096691	COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers. (2015 Jul)	Bowers H	Genes Brain Behav
29333880	Pharmacogenetic analysis of opioid dependence treatment dose and dropout rate. (2018)	Crist RC	Am J Drug Alcohol Abuse
27613936	High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)	Fiatal S	Nicotine Tob Res
24095246	Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study. (2013 Dec 15)	Ashare RL	Drug Alcohol Depend
17135598	No evidence for a major role of polymorphisms during bupropion treatment. (2006 Nov)	Hu J	Obesity (Silver Spring)
22729568	Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer. (2013 Sep)	Recio-Vega R	J Appl Toxicol
14520706	Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk. (2003 Nov 20)	Saintot M	Int J Cancer
26000819	A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. (2016)	Zhang Y	Int J Neurosci
25491588	Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population. (2015 Sep)	Shibata N	Int J Geriatr Psychiatry
24443099	Effect of COMT Val108/158Met genotype on risk for polydipsia in chronic patients with schizophrenia. (2014 Jun)	Yamada K	Neuromolecular Med
17928119	Genetics of Lesch's typology of alcoholism. (2008 Feb 15)	Samochowiec J	Prog Neuropsychopharmacol Biol Psychiatry
20868372	Perinatal risk factors interacting with catechol O-methyltransferase and the serotonin transporter gene predict ASD symptoms in children with ADHD. (2010 Nov)	Nijmeijer JS	J Child Psychol Psychiatry
26616111	Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis. (2016 Apr)	Taylor S	Am J Med Genet B Neuropsychiatr Genet
17143180	Association of genetic polymorphisms of ACADSB and COMT with human hypertension. (2007 Jan)	Kamide K	J Hypertens
25035107	Association of gene polymorphisms encoding dopaminergic system components and platelet MAO-B activity with alcohol dependence and alcohol dependence-related phenotypes. (2014 Oct 3)	Nedic Erjavec G	Prog Neuropsychopharmacol Biol Psychiatry
21883922	Association of BDNF and COMT genotypes with cognitive processing of anti-smoking PSAs. (2011 Nov)	Falcone M	Genes Brain Behav
17205121	Catechol-o-methyltransferase gene polymorphism modifies the effect of coffee intake on incidence of acute coronary events. (2006 Dec 27)	Happonen P	PLoS One
19827313	[Association between nicotine dependence and the -521 promoter polymorfism of the dopamine D4 receptor in patients with major depression]. (2009 Jun)	Kotyuk E	Neuropsychopharmacol Hung
17451372	Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study. (2007 Aug)	Lorentzon M	J Bone Miner Res
19940429	Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). (2009 Nov)	Blum K	Postgrad Med
18923401	Does COMT val158met affect behavioral phenotypes: yes, no, maybe? (2008 Dec)	Lachman HM	Neuropsychopharmacology
26447226	Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)	Celorrio D	Alcohol Alcohol
25875614	Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. (2015 May)	Levran O	Ann Hum Genet
18574484	The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. (2010 Feb)	Mukherjee N	Mol Psychiatry
11927842	No association between functional catechol O-methyl transferase 1947A>G polymorphism and smoking initiation, persistent smoking or smoking cessation. (2002 Apr)	David SP	Pharmacogenetics
14729580	Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. (2004 Jun)	Hung RJ	Carcinogenesis
11434504	Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer. (2001 Jun)	Yim DS	Pharmacogenetics
15654505	Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)	Liu Y	J Hum Genet
24902721	Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. (2014 Sep)	van der Knaap LJ	Genes Brain Behav
22740151	Impact of COMT Val 108/158 Met and DRD2 Taq1B gene polymorphisms on vulnerability to cigarette smoking of Thai males. (2013 Mar)	Suriyaprom K	J Mol Neurosci
24390676	COMT Associations with Disordered Gambling and Drinking Measures. (2015 Jun)	Guillot CR	J Gambl Stud
22509987	COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence. (2013 Mar)	Schellekens AF	Addict Biol
7969881	Some biological mechanisms of the inborn predisposition to alcoholism. (1994 May-Jun)	Anokhina IP	Neurosci Behav Physiol
22645715	Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study. (2012)	Heck JE	Front Oncol
12741370	Plasma homovanillic acid: a significant association with alcoholism is independent of a functional polymorphism of the human catechol-O-methyltransferase gene. (2003 May)	Kohnke MD	Neuropsychopharmacology
28192769	Disorganization at the stage of schizophrenia clinical outcome: Clinical-biological study. (2017 May)	Nestsiarovich A	Eur Psychiatry
15900212	Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women. (2005 Jun)	Colilla S	Pharmacogenet Genomics
17264883	Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study. (2007 Jan 31)	Voutilainen S	PLoS One
16417624	Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer. (2006 Jan 17)	Bradbury BD	J Carcinog
17577421	The impact of the catechol-O-methyltransferase Val158Met polymorphism on survival in the general population--the HUNT study. (2007 Jun 19)	Hagen K	BMC Med Genet
18270997	Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women. (2008 Sep 5)	Oosterhuis BE	Am J Med Genet B Neuropsychiatr Genet
21312287	Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence - role of gene-gene interaction, personality, and environmental factors. (2010 Nov)	Greenbaum L	Hum Psychopharmacol
18486967	A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A). (2008 Jul)	Shiels MS	Prev Med
24448104	Cigarettes, genetic background, and menopausal timing: the presence of single nucleotide polymorphisms in cytochrome P450 genes is associated with increased risk of natural menopause in European-American smokers. (2014 Jul)	Butts SF	Menopause
22474103	Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the role of the COMT Val158Met and DRD2 Taq1A genotypes. (2012 Apr)	Schellekens AF	Arch Gen Psychiatry
23087644	Associations of Cigarette Smoking and Polymorphisms in Brain-Derived Neurotrophic Factor and Catechol-O-Methyltransferase with Neurocognition in Alcohol Dependent Individuals during Early Abstinence. (2012)	Durazzo TC	Front Pharmacol
16053757	[A paired case-control study on related factors to attempted suicide]. (2005 May)	Jia CX	Zhonghua Liu Xing Bing Xue Za Zhi
22978509	Convergence of genome-wide association and candidate gene studies for alcoholism. (2012 Dec)	Olfson E	Alcohol Clin Exp Res
19462300	Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine. (2009)	Haile CN	Am J Drug Alcohol Abuse
22695756	Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy. (2012 Dec)	Sun H	J Neural Transm (Vienna)
12605066	Genetics of alcoholism using intermediate phenotypes. (2003 Feb)	Enoch MA	Alcohol Clin Exp Res
10395222	Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. (1999 May)	Tiihonen J	Mol Psychiatry
23941313	Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. (2013 Dec)	David SP	Addiction
28472995	Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men. (2017 May 4)	Ou WC	Behav Brain Funct
27644662	CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population. (2016)	Kakino K	Asian Pac J Cancer Prev
24118473	Val158Met COMT polymorphism and risk of aggression in alcohol dependence. (2015 Jan)	Soyka M	Addict Biol
22738861	Genetic association between obstructive bronchitis and enzymes of oxidative stress. (2012 Dec)	Bauer M	Metabolism
28913946	Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met. (2017 Nov)	Carra G	Hum Psychopharmacol
25655461	Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)	Manzardo AM	Gene
19174490	Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. (2009 Apr)	Cote ML	Carcinogenesis
26288297	[Stabilization of remission in patients with opioid dependence with naltrexone implant: a pharmacogenetic approach]. (2015)	Krupitsky capital IE, Cyrilliccapital EM, Cyrillic	Zh Nevrol Psikhiatr Im S S Korsakova
12415427	Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population. (2002 Nov)	Kocabas NA	Arch Toxicol
16679343	Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder. (2006 Jul-Aug)	Kim JW	Alcohol Alcohol
12036914	Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer. (2002 Jun 1)	Garner EI	Cancer Res
17467918	Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis. (2007)	Blum K	Med Hypotheses
28471875	Genetic predictors of recovery in low back and lumbar radicular pain. (2017 Aug)	Bjorland S	Pain
20517217	[Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history]. (2010)	Kibitov AO	Zh Nevrol Psikhiatr Im S S Korsakova
23288874	Lack of association of a functional catechol-O-methyltransferase gene polymorphism with risk of tobacco smoking: results from a multicenter case-control study. (2013 Jul)	Mutschler J	Nicotine Tob Res
17850222	Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. (2007 Nov)	Foroud T	Alcohol Clin Exp Res
15900232	Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics. (2005 Jun)	Kweon YS	Psychiatr Genet
15584875	Alcoholism: genes and mechanisms. (2004 Dec)	Oroszi G	Pharmacogenomics
20603187	Smoking, genes encoding dopamine pathway and risk for Parkinson's disease. (2010 Sep 20)	Gu Z	Neurosci Lett
19023276	COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study. (2009 Jan)	Stewart SH	Am J Hypertens
29310047	Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats. (2018 Mar)	McCane AM	Alcohol
17206495	Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. (2007 Mar)	Guo S	Psychopharmacology (Berl)
19160592	The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study. (2009 Jan)	Omidvar M	Pharmacogenet Genomics
21106664	Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women. (2011 Feb)	Munafo MR	Nicotine Tob Res
19443378	Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort. (2009 May)	Fontana L	Anticancer Res
10767640	Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer. (2000 Apr)	Martone T	Mutat Res
26555332	Association between catechol-O-methyltransferase (COMT) Val/Met genotype and smoking cessation treatment with nicotine: a meta-analysis. (2015 Nov)	Choi HD	Pharmacogenomics
27898499	COMT and BDNF Gene Variants Help to Predict Alcohol Consumption in Alcohol-dependent Patients. (2017 Mar/Apr)	Klimkiewicz A	J Addict Med
26882038	AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers. (2016 Feb 16)	Morgan CJ	Transl Psychiatry
22309446	Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density. (2012 Apr)	Cao YA	Behav Neurosci
28259004	Age-dependent role of pre- and perinatal factors in interaction with genes on ADHD symptoms across adolescence. (2017 Jul)	Brinksma DM	J Psychiatr Res
19415821	Gene-gene interactions of CYP2A6 and MAOA polymorphisms on smoking behavior in Chinese male population. (2009 May)	Tang X	Pharmacogenet Genomics
22790479	Association of COMT gene polymorphisms with systemic atherosclerosis in elderly Japanese. (2012)	Ko MK	J Atheroscler Thromb
10698363	Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers. (2000 Feb)	Kauhanen J	Alcohol Clin Exp Res
17548664	Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial. (2007 Jun)	Johnstone EC	Cancer Epidemiol Biomarkers Prev
28361821	Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov)	Malhotra S	Indian J Med Res
26202054	Interaction between smoking history and gene expression levels impacts survival of breast cancer patients. (2015 Aug)	Andres SA	Breast Cancer Res Treat
16223057	COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms. (2005 Jul)	Goldman D	J Stud Alcohol Suppl
20860878	Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence. (2011 Apr)	Nedic G	Int J Neuropsychopharmacol
21781348	Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. (2011 Jul 25)	Kiyohara C	BMC Neurol
19065145	Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. (2009 Aug)	Loughead J	Mol Psychiatry
26410615	An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans. (2015 Nov)	Bidwell LC	Pharmacol Biochem Behav
11204347	Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. (2000 Sep)	Nolan KA	Psychiatr Genet
10551543	Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholism. (1999 Sep)	Ishiguro H	Psychiatr Genet
25545355	Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. (2014)	O'Loughlin J	PLoS One
21300759	EGFR L858R mutation and polymorphisms of genes related to estrogen biosynthesis and metabolism in never-smoking female lung adenocarcinoma patients. (2011 Apr 15)	Yang SY	Clin Cancer Res
21397529	Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt. (2012 Nov-Dec)	Wolpert BJ	Urol Oncol
19944543	Adolescent cannabis use increases risk for cocaine-induced paranoia. (2010 Mar 1)	Kalayasiri R	Drug Alcohol Depend
28300812	[A pharmacogenetic analysis of dopaminergic and opioidergic genes in opioid addicts treated with the combination of naltrexone and guanfacine]. (2016)	Kibitov capital A, Cyrilliccapital O, Cyrillic	Zh Nevrol Psikhiatr Im S S Korsakova
17497175	Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial. (2007 Aug)	Wang SS	Hum Genet
21129090	CYP17, catechol-o-methyltransferase, and glutathione transferase M1 genetic polymorphisms, lifestyle factors, and breast cancer risk in women on Prince Edward Island. (2011 Jan-Feb)	Cribb AE	Breast J
11900601	Association between catechol-O-methyltransferase (COMT) polymorphism and severe alcoholic withdrawal symptoms in male Japanese alcoholics. (2001 Jul)	Nakamura A	Addict Biol
20712524	Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. (2010 Aug)	De Ruyck K	Pharmacogenomics
20801583	Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. (2010 Dec)	Brousse G	Med Hypotheses
18181582	Design of electrochemical biosensor systems for the detection of specific DNA sequences in PCR-amplified nucleic acids related to the catechol-O-methyltransferase Val108/158Met polymorphism based on intrinsic guanine signal. (2008 Feb 1)	Ozkan-Ariksoysal D	Anal Chem
21083670	Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (2011 Feb)	Hack LM	Alcohol Clin Exp Res
24444411	Pharmacogenetics of nicotine addiction: role of dopamine. (2014 Feb)	Herman AI	Pharmacogenomics
18499348	Nicotine abstinence-induced cerebral blood flow changes by genotype. (2008 Jun 27)	Wang Z	Neurosci Lett
26810137	Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder. (2017 Jan)	Pagerols M	Pharmacogenomics J
25364629	Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory. (2013 Oct 1)	Hill SY	Adv J Mol Imaging
17079080	Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence. (2006 Dec 13)	Samochowiec J	Neurosci Lett
23504072	Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)	Fehr C	J Neural Transm (Vienna)
17885625	Association study of monoamine oxidase and catechol-O-methyltransferase genes with smoking behavior. (2007 Oct)	Tochigi M	Pharmacogenet Genomics
18258609	A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (2008 Jun)	Zienolddiny S	Carcinogenesis
12011284	MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. (2002 May 14)	Hernan MA	Neurology
16648777	The association between high-activity COMT allele and alcoholism. (2006 Feb-Apr)	Sery O	Neuro Endocrinol Lett
29781244	OPRM1 influence on and effectiveness of an individualized treatment plan for prescription opioid use disorder patients. (2018 May 20)	Muriel J	Ann N Y Acad Sci
23828159	Association of abstinence-induced alterations in working memory function and COMT genotype in smokers. (2013 Dec)	Ashare RL	Psychopharmacology (Berl)
25280560	Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk. (2014 Oct 4)	Tan X	Diagn Pathol
20975619	Are genetic variants of COMT associated with addiction? (2010 Dec)	Tammimaki AE	Pharmacogenet Genomics
21356266	Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes. (2011 Apr)	Brennan PA	Biol Psychol
22466345	Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women. (2012 Jun)	Butts SF	J Clin Endocrinol Metab
22208661	A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: a case control study. (2011 Dec 31)	Voisey J	Behav Brain Funct
6641500	Platelet monoamine oxidase and erythrocyte catechol-o-methyltransferase activity in alcoholism and controlled abstinence. (1983 Aug)	Agarwal DP	Drug Alcohol Depend
16876132	Catechol-O-methyltransferase (COMT) gene variants predict response to bupropion therapy for tobacco dependence. (2007 Jan 1)	Berrettini WH	Biol Psychiatry
22370993	Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics. (2012 Apr)	Ellingrod VL	J Clin Psychopharmacol
17448448	Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in schizophrenia. (2007 Oct 1)	Lu BY	Biol Psychiatry
21330274	Pharmacogenetics of smoking cessation in general practice: results from the patch II and patch in practice trials. (2011 Mar)	David SP	Nicotine Tob Res
21423427	Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking. (2010)	Xu Q	Front Psychiatry